Pharmaceuticals in Rivers of Two Regions with Contrasted Socio-Economic Conditions: Occurrence, Accumulation, and Comparison for Ukraine and France

Vystavna, Yuliya; Huneau, Frédéric; Grynenko, Volodymyr; Vergeles, Yuriy; Celle-Jeanton, Hélène; Tapie, Nathalie; Budzinski, Hélène; Coustumer, Philippe Le

doi:10.1007/s11270-011-1008-1

Cited by 81 publications

(25 citation statements)

References 42 publications

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“…Several monitoring studies have reported the presence of pharmaceuticals in urban wastewaters (Al-Rifai et al, 2007;Brown et al, 2006;Bueno et al, 2012;Gracia-Lor et al, 2011;Gros et al, 2006;Pedrouzo et al, 2011) and surface waters (Daneshvar et al, 2010;González Alonso et al, 2010;Kolpin et al, 2002;Martín et al, 2011;Spongberg et al, 2011;Vystavna et al, 2012). Nevertheless, few data is available on the contribution of hospital effluents towards the load of pharmaceuticals in WWTPs (Beier et al, 2011;Langford and Thomas, 2009;Ort et al, 2010;Thomas et al, 2007;Verlicchi et al, 2012a).…”

Section: Introductionmentioning

confidence: 99%

Contribution of hospital effluents to the load of pharmaceuticals in urban wastewaters: Identification of ecologically relevant pharmaceuticals

Santos

Gros²,

Rodríguez-Mozaz³

et al. 2013

Science of The Total Environment

535

216

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The impact of effluent wastewaters from four different hospitals: a university (1456 beds), a general (350 beds), a pediatric (110 beds) and a maternity hospital (96 beds), which are conveyed to the same wastewater treatment plant (WWTP), was evaluated in the receiving urban wastewaters. The occurrence of 78 pharma-ceuticals belonging to several therapeutic classes was assessed in hospital effluents and WWTP wastewaters (influent and effluent) as well as the contribution of each hospital in WWTP influent in terms of pharmaceu-tical load. Results indicate that pharmaceuticals are widespread pollutants in both hospital and urban waste-waters. The contribution of hospitals to the input of pharmaceuticals in urban wastewaters widely varies, according to their dimension. The estimated total mass loadings were 306 g d − 1 for the university hospital, 155 g d − 1 for the general one, 14 g d −1 for the pediatric hospital and 1.5 g d − 1 for the maternity hospital, showing that the biggest hospitals have a greater contribution to the total mass load of pharmaceuticals. Fur-thermore, analysis of individual contributions of each therapeutic group showed that NSAIDs, analgesics and antibiotics are among the groups with the highest inputs. Removal efficiency can go from over 90% for pharmaceuticals like acetaminophen and ibuprofen to not removal for β-blockers and salbutamol. Total mass load of pharmaceuticals into receiving surface waters was estimated between 5 and 14 g/d/1000 inhabitants. Finally, the environmental risk posed by pharmaceuticals detected in hospital and WWTP effluents was assessed by means of hazard quotients toward different trophic levels (algae, daphnids and fish). Several pharmaceuticals present in the different matrices were identified as potentially hazardous to aquatic organ-isms, showing that especial attention should be paid to antibiotics such as ciprofloxacin, ofloxacin, sulfameth-oxazole, azithromycin and clarithromycin, since their hazard quotients in WWTP effluent revealed that they could pose an ecotoxicological risk to algae.

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Section: Introductionmentioning

confidence: 99%

Contribution of hospital effluents to the load of pharmaceuticals in urban wastewaters: Identification of ecologically relevant pharmaceuticals

Santos

Gros²,

Rodríguez-Mozaz³

et al. 2013

Science of The Total Environment

535

216

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“…In US and Europe, more than 80 PPCPs were detected at concentrations of up to mg/L level in different water bodies [78,83,84]. Based on the research carried out by Vystvna et al [85], it was suggested that diclofenac, caffeine and carbamazepine are useful chemical markers for tracing wastewater contamination in France and Ukraine. Similarly, the use of persistent marker (carbamazepine) and labile markers (acetaminophen and salicylic acid) has been successfully applied to detect wastewater contamination in surface water and groundwaters by Tran et al [29].…”

Section: Pharmaceuticals and Personal Care Products (Ppcps)mentioning

confidence: 99%

Recent Advances in the Use of Chemical Markers for Tracing Wastewater Contamination in Aquatic Environment: A Review

Lim

Ong

2017

Water

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There has been increasing research focus on the detection and occurrence of wastewater contamination in aquatic environment. Wastewater treatment plants receive effluents containing various chemical pollutants. These chemicals may not be fully removed during treatment and could potentially enter the receiving water bodies. Detection of these chemical pollutants and source identification could be a challenging research task due to the diversified chemical and functional groups, concentration levels and fate and transportation mechanisms of these pollutants in the environment. Chemical markers such as pharmaceuticals and personal care products, artificial sweeteners, fluorescent whitening agents, sterols and stanols, and nitrate and nitrogen isotopics have been widely used by most research as markers. These markers served as indicators of wastewater contamination to the receiving bodies due to their frequent usage, resistance to biodegradability and, more importantly, anthropogenic origin. These markers are commonly used in combination to identify the contaminant source of different origins. This article discusses the main chemical markers that are used to identify wastewater contamination in receiving bodies, the current trends, and approach to select suitable chemical markers.

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“…Screening studies usually cover a wide range of chemicals in order to monitor local contamination and/or its seasonal changes. Vystavna et al (2012; even compare the profiles obtained from two different regions with contrasting socio-economic conditions. In some cases, only a specific range of substances is included in the study.…”

Section: Target Analytes and Sampling Sitesmentioning

confidence: 99%

“…Other extraction media, e.g. ACN (Amdany et al 2014a), acetone (Tanwar et al 2015), MeOH/water (Bailly et al 2013;Creusot et al 2014) or MeOH/dichloromethane (Vystavna et al 2012;Creusot et al 2013;Morin et al 2013;Vystavna et al 2013) are also suitable. Some authors adjust the pH in order to improve the extraction (Harman et al 2011;Cernoch et al 2012;Bayen et al 2014;Shi et al 2014).…”

Section: Extraction and Analytical Techniquesmentioning

confidence: 99%

Passive sampling of pharmaceuticals and personal care products in aquatic environments

Křesinová

Petrů

Lhotský

et al. 2016

European Journal of Environmental Sciences

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Passive sampling is a rapidly developing technology, which is widely used for the monitoring of pollutants in different environments. Passive sampling offers significant advantages over traditional grab sampling. In the present review, the authors summarize the current literature on the methods of passive sampling used in the environmental monitoring of polar or semi-polar compounds in aqueous matrices. Methods of calibrating, design and deployment of samplers are also discussed. A major focus of this review is the use of polar organic compound integrative samplers (POCIS) and their use in sampling and monitoring of pharmaceuticals and personal care products (PCPs) in both equilibrium and non-equilibrium conditions.

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Pharmaceuticals in Rivers of Two Regions with Contrasted Socio-Economic Conditions: Occurrence, Accumulation, and Comparison for Ukraine and France

Cited by 81 publications

References 42 publications

Contribution of hospital effluents to the load of pharmaceuticals in urban wastewaters: Identification of ecologically relevant pharmaceuticals

Contribution of hospital effluents to the load of pharmaceuticals in urban wastewaters: Identification of ecologically relevant pharmaceuticals

Recent Advances in the Use of Chemical Markers for Tracing Wastewater Contamination in Aquatic Environment: A Review

Passive sampling of pharmaceuticals and personal care products in aquatic environments

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