Pharmaceuticals removal in an on-farm pig slurry treatment plant based on solid-liquid separation and nitrification-denitrification systems

Marti, Elisabet; Gros, Meritxell; Boy-Roura, Mercè; Ovejero, Jonatan; Busquets, Anna María; Petrović, Mira; Ponsá, Sergio

doi:10.1016/j.wasman.2019.11.001

Cited by 23 publications

(6 citation statements)

References 27 publications

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“…Solid samples: 0.5 g of freeze-dried and ground samples were measured and spiked with standard solutions as reported by Marti et al [ 21 ]. Solid samples were extracted by passing through three different solid extraction solutions, where samples were transferred into a centrifuge tube and 4 mL of extraction buffer was added as follows: (T1): a mixture (50:50 v/v ) of MeOH/ACN and pH adjusted to 3.0; (T2): saturated aqueous Na 2 EDTA, water, and Na 2 EDTA–McIlvaine buffer (pH 4.0) as developed by Li et al [ 7 ]; (T3): a mixture between a McIlvaine buffer (0.1 M Na 2 EDTA) solution, and MeOH at a ratio of 25:25:50 (based on the volume v/v/v ), and pH was adjusted to 7.2 by adding 6N NaOH solution.…”

Section: Methodsmentioning

confidence: 99%

Determination of Tetracycline, Oxytetracycline, Sulfadiazine, Norfloxacin, and Enrofloxacin in Swine Manure Using a Coupled Method of On-Line Solid-Phase Extraction with the UHPLC–DAD

Gaballah

Zhang

et al. 2021

Antibiotics

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The use of various veterinary antibiotics (VAs) in animal husbandry raises serious concerns about the development of antibiotic resistance. Antibiotics such as tetracycline, oxytetracycline, sulfadiazine, norfloxacin, and enrofloxacin are the most frequently used antimicrobial compounds in animal husbandry and generate large eco-toxicological effects; however, they are still difficult to determine in a complex matrix such as swine manure. This study has developed an effective method for detecting five VAs in swine manure using Ultra-High-Performance Liquid Chromatography–Diode Array Detector (UHPLC–DAD) coupled with on-line solid-phase extraction (SPE). The results show that the mobile phase of ACN/0.01 M oxalic acid was the optimum at pH 3.0. VAs in a swine manure matrix were extracted using solid extraction buffer solution (T3) with 97.36% recovery. Sensitivity, accuracy, and precision were also evaluated. The validity study showed good linearity (R2 > 0.99). Limit of detection (LOD) was found to be from 0.1 to 0.42 µg mL−1 in the liquid fraction and from 0.032 to 0.58 µg g−1 dw in the solid fraction. The corresponding values of the limit of quantification (LOQ) ranged from 0.32 to 1.27 µg mL−1 for the liquid fraction and from 0.096 to 1.77 µg g−1 dw for the solid fraction. Therefore, the proposed method showed the potential applicability for detecting different antibiotic compounds from swine manure samples.

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Section: Methodsmentioning

confidence: 99%

Determination of Tetracycline, Oxytetracycline, Sulfadiazine, Norfloxacin, and Enrofloxacin in Swine Manure Using a Coupled Method of On-Line Solid-Phase Extraction with the UHPLC–DAD

Gaballah

Zhang

et al. 2021

Antibiotics

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“…Digestate was collected from an on-farm livestock waste treatment plant where pig slurry, slaughterhouse sludge and food waste are fed into a mesophilic anaerobic digestor with a working volume of 5000 m 3 and a hydraulic retention time of 75-80 d [30]. The liquid fraction from pig slurry was collected in a fattening pig farm where mechanical solid-liquid separation with a press screw separator is undertaken [31]. Before its treatment with the VSEP system, the liquid fraction from pig slurry was screened using a SWECO vibrating screen provided by New Logic Research, Inc. (Emeryville, CA, USA) with a screen size down to 120 µm in order to remove abrasive solids which could damage the membranes and pumps integrated in the VSEP unit.…”

Section: Selection Of Feedstocksmentioning

confidence: 99%

Application of Vibrating Reverse Osmosis Technology for Nutrient Recovery from Pig Slurry in a Circular Economy Model

et al. 2022

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The rapid growth of the livestock sector in some areas of Europe has caused an imbalance between the generation of livestock manure and the availability of agricultural soil for its direct application as a fertilizer. Since the transport of pig slurry to other areas with nutrient-deficient soils is costly from an economic point of view due to its high water content, the application of new technologies for the concentration of this waste is considered key for reducing management costs. Consequently, the main objective of this study was to demonstrate the potential of vibratory shear enhanced processing (VSEP) operated with reverse osmosis membranes to recover nutrients from the liquid fractions of pig slurry (LF-pig slurry) and digestate (LF-digestate) and obtain concentrated fertilizing products. Use of the VSEP unit permitted reductions in the water contents of the LF-pig slurry and LF-digestate, around 77% and 67%, respectively. Both VSEP concentrates were characterized by their significant nutrient contents and showed a nitrogen fertilizer replacement value similar to that of mineral fertilizer as demonstrated in a barley crop pot-test, although the salinity of the digestate concentrate was identified as a key limitation, negatively impacting the agronomic yield of the test crop.

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“…The best way to manage them is by their destruction before they leave the farm. Several methods are being studied to avoid antibiotic release, such as heating [30,31], sorption of antibiotics onto carbonaceous materials [18], anaerobic digestion [32,33], manure composting [34,35], solid-liquid separation [36], and Fenton reaction [37]. These procedures involve a series of technologies, the choice of which will be dependent on the antimicrobial used and the concentration excreted, which, in turn, will depend on the moment of therapy.…”

Section: Introductionmentioning

confidence: 99%

Antibacterial Residue Excretion via Urine as an Indicator for Therapeutical Treatment Choice and Farm Waste Treatment

et al. 2021

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Many of the infectious diseases that affect livestock have bacteria as etiological agents. Thus, therapy is based on antimicrobials that leave the animal’s tissues mainly via urine, reaching the environment through slurry and waste water. Once there, antimicrobial residues may lead to antibacterial resistance as well as toxicity for plants, animals, or humans. Hence, the objective was to describe the rate of antimicrobial excretion in urine in order to select the most appropriate molecule while reducing harmful effects. Thus, 62 pigs were treated with sulfamethoxypyridazine, oxytetracycline, and enrofloxacin. Urine was collected through the withdrawal period and analysed via LC-MS/MS. Oxytetracycline had the slowest rate of degradation (a half-life time of 4.18 days) and the most extended elimination period in urine (over 2 months), followed by enrofloxacin (a half-life time of 1.48 days, total urine elimination in ca. 3 weeks) and sulfamethoxypyridazine (a half-life time of 0.49 days, total urine elimination in ca. 1 week). Bacterial sensitivity and recommendations for responsible use are limiting when selecting the treatment. Nevertheless, with similar effectiveness, sulfamethoxypyridazine would be the choice, as waste treatment would only need to be implemented for 1 week after treatment. Thus, more in-depth knowledge regarding antibacterial elimination would improve resource management, while protecting animals and consumers’ health.

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Pharmaceuticals removal in an on-farm pig slurry treatment plant based on solid-liquid separation and nitrification-denitrification systems

Cited by 23 publications

References 27 publications

Determination of Tetracycline, Oxytetracycline, Sulfadiazine, Norfloxacin, and Enrofloxacin in Swine Manure Using a Coupled Method of On-Line Solid-Phase Extraction with the UHPLC–DAD

Determination of Tetracycline, Oxytetracycline, Sulfadiazine, Norfloxacin, and Enrofloxacin in Swine Manure Using a Coupled Method of On-Line Solid-Phase Extraction with the UHPLC–DAD

Application of Vibrating Reverse Osmosis Technology for Nutrient Recovery from Pig Slurry in a Circular Economy Model

Antibacterial Residue Excretion via Urine as an Indicator for Therapeutical Treatment Choice and Farm Waste Treatment

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