Pharmaceutico-analytical profile of Mrityunjay Rasa and evaluation of its Antibacterial activity

Abstract

Background: Mrityunjay Rasa is the one of the Kharaliya Kalpana explained in Yogaratnakara in Jwara chikitsa and indicated in all types of fever. Any pathology can leads to diseases which are easily seen by fever as a clinical symptom. Bacterial infections through the skin or by any system defiantly reflect through fever and as told in classics Mrityunjay Rasa is having the capacity to eradicate all types of Jwara. Aim & Objective: The study is planned to evaluate the antibacterial activity of Mrityunjay Rasa. Material and methods: Mrityunjay rasa was prepared according to Yogratnakar at the Department of Rasashastra & Bhaishajya Kalpana. The formulation was tested for organoleptic characters, physicochemical parameters and microbial specification tests. Observation and results: Standard Mrityunjay rasa can be prepared from three Bhawana of Ardraka swarasa each for an average of 11.55 hrs. Prepared Mrityunjay rasa was Reddish in color with a specific smell and 145.57% average yield. Analytical standards for Mrityunjay rasa such as loss on drying at 105oC, total ash, acid insoluble ash, alcohol soluble extractives, water-soluble extractive, pH, Hardness, Disintegration time and particle size were 2.10%, 15.87%, 2.43%, 2.29%, 20.43 %, 8.7 (10% aqueous solution), 3, 30 minutes 20 sec and 95.41 respectively. Mrityunjay Rasa has shown a better zone of inhibition against Staphylococcus aureus. Conclusion: Analytical parameters obtained through the present study can be considered as a reference standard for Mrityunjay rasa.

Mercuric-sulphide based metallopharmaceutical formulation as an alternative therapeutic to combat viral and multidrug-resistant (MDR) bacterial infections

“…Padikara Parpam had been reported with a ZOI of 14 mm at 4 mg/mL concentration 67 and Mupoora Chendooram was identified with a ZOI of 10 mm at the concentration of 25 mg/mL 22 against S. aureus. Similarly, Mrityunjay Rasa sample showed a ZOI of 20 mm 68 , Thazhampoo Mathirai displayed a ZOI of 16 mm 69 , Kanagalinga Mezhugu presented a ZOI of 15–19 mm 70 . However, all these results showing ZOI against S. aureus strains were comparatively lesser than the potential activity of Sivanar Amirtham .…”

“…The activity of the metallo drugs toward the microorganisms could be linked to the variations in the morphological characteristics between gram-positive and gram-negative microorganisms 75 . Herbomineral formulations like Mrityunjay Rasa and Mahavat Vidhwansan Rasa also showed no activity against P. aeruginosa 68 , 71 . This might be due to the surface charge and the electrostatic attraction between the metal complexes with microbes.…”

Evaluation of Repeated Dose (Sub Chronic) Toxicity Study of Shilasindur Prepared by Two Different Methods Along with Its Characterization and Antimicrobial Activity

“…Studies on efficacy of various Ayurvedic formulations were reported. Few of the related studies were reviewed [29][30].…”

Pharmaceutico Analytical Study of Roudra Rasa and Evaluation of Its Anti-Carcinogenic Effect in Selected Cell Lines and Acute Toxicity Studies in Albino Wistar Rats: A Study Protocol

“…capabilities) and yogavahi (capacity to deliver drugs to specific tissues) properties, it's also non -toxic, gentle to absorb, adaptive, and digestible in the body.The Bhasma of Rasashastra are indeed the tune of modern nanoparticle technology [16][17][18].…”