Pharmacist intervention in drug-related problems for patients with cardiovascular diseases in selected community pharmacies in Northern Cyprus

Gokcekus, Laika; Meštrović, Arijana; Başgut, Bilgen

doi:10.4314/tjpr.v15i10.29

Cited by 14 publications

(10 citation statements)

References 11 publications

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“…The estimated magnitude of DRPs in patients with hypertensive and diabetes in this review was higher compared to the magnitude reported in a study conducted in Nigeria; 49.8% and 50.2% in hypertensive and diabetic patients, respectively [ 58 ]. Likewise, the estimated magnitude of DRPs in heart failure patients was higher compared to results reported in a study conducted in Spain (29.8%) [ 58 ] and North Cyprus (63%) [ 61 ].…”

Section: Discussioncontrasting

confidence: 56%

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Drug-related problems and associated factors in Ethiopia: a systematic review and meta-analysis

Adem

Abdela

Edessa

et al. 2021

J of Pharm Policy and Pract

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Background Drug-related problems (DRPs) can occur at any stages of medication use processes, and a single drug could be associated with multiple DRPs. Once happened, it adversely affects health outcomes. In Ethiopia, evaluation of the magnitude and factors associated with DRPs had not been attempted at the national level. Method The literature search was conducted in the following databases; PubMed, Embase, Medline, and Google Scholar. The quality of the included studies was checked using Joanna Brigg’s Institute (JBI’s) checklist, and data were analyzed using Stata software (version 14.0). The pooled estimate of DRPs was computed by a Random effect model (DerSimonian–Laird method). Cochran’s Q test (I2) statistic)), and Begg’s correlation and Egger’s regression test were assessed for heterogeneity and publication bias, respectively. Result Overall, 32 studies with a total sample size of 7,129 were included in the review. The estimated pooled prevalence of DRPs was 70% [0.70 (95% CI 0.64—0.76; I2 = 97.6% p = 0.000)]. Polypharmacy (taking ≥ 5 drugs) [RR = 1.3], medical comorbidity [RR = 1.3], poor medication adherence [RR = 1.7], uncontrolled blood pressure [RR = 1.4], substance use [RR = 1.2], type 2 diabetes [RR = 1.8], significant drug interaction [RR = 1.33], and a negative medication belief [RR = 3.72] significantly influenced the occurrence of DRPs. Conclusion The estimated national prevalence of DRPs in Ethiopia was high. Presence of medical comorbidity, using multiple drugs, significant drug interaction, poor medication adherence, uncontrolled blood pressure, type 2 diabetes, substance use and a negative belief about medication significantly influenced the occurrence of DRPs. Initiating and/or strengthening pharmaceutical care services at the health care facilities could lower the occurrence of DRPs. PROSPERO registration number CRD42020162329.

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Section: Discussioncontrasting

confidence: 56%

“…Likewise, the estimated magnitude of DRPs in heart failure patients was higher compared to results reported in a study Fig. 3 Sub-group analysis of drug-related problems by unnecessary drug therapy in Ethiopia conducted in Spain (29.8%) [58] and North Cyprus (63%) [61].…”

Section: Discussionmentioning

confidence: 67%

Drug-related problems and associated factors in Ethiopia: a systematic review and meta-analysis

Adem

Abdela

Edessa

et al. 2021

J of Pharm Policy and Pract

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“…This result was comparable with studies carried out in Southern India and Karnataka, India, which revealed that clinical pharmacists' acceptance was about 97% and 96%, respectively [ 36 , 37 ]. Moreover, a study carried out in Ghana, South Western Saudi Arabia, Northern Cyprus, and India showed that clinical pharmacists' intervention and acceptance rates were about two-thirds of the study population [ 38 – 40 ].…”

Section: Discussionmentioning

confidence: 99%

Drug-related problems and its predictors among hospitalized heart failure patients at Jimma Medical Center, South West Ethiopia: prospective interventional study

Sefera

Getachew

Babu

et al. 2022

BMC Cardiovasc Disord

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Background Drug-related problems are associated with high mortality, complications, prolonged hospital stay, compromised quality of life, and increased healthcare costs. This problem is high in patients hospitalized with chronic conditions such as heart failure. However, there are limited studies conducted on this area, particularly in Ethiopia. Objective To evaluate drug-related problems, their predictors, and clinical pharmacist intervention among hospitalized heart failure patients at Jimma Medical Center, Ethiopia. Methods and participants A prospective interventional study was conducted among hospitalized heart failure patients from September 30, 2020, to May 28, 2021, at Jimma Medical Center. Drug-related problems were sorted based on the Pharmaceutical Care Network Europe drug classification tool version 9.0. Patient's specific data were collected using a structured questionnaire. Data was analyzed using statistical software package version 23.0. Multivariate logistic regression analysis was used to identify independent predictors of drug-related problems occurrence and statistical significance was considered at a p value < 0.05. Results A total of 237 heart failure patients were included in this study. The mean (SD) age was 49.06 + 17.79. About two-thirds (66.2%) of study patients had at least one drug-related problem during their hospital stay. A total of 283 drug-related problems were identified among 157 patients. Treatment effectiveness-related problem (55.48%) was the most common observed drug-related problem. The independent predictors of drug-related problems were khat chewing [AOR = 3.25, 95% CI = (1.46–7.23)], hospital stay > 18 days [AOR = 3.77, 95% CI = (1.93–7.37)]; presence of comorbid condition [AOR = 2.59, 95% CI = (1.35–4.96)] and polypharmacy [AOR = 2.94, 95% CI = (1.54–5.61)]. Conclusion The prevalence of drug-related problems was high among hospitalized heart failure patients in the study area. Chewing khat, prolonged hospital stay, comorbidity, and polypharmacy were the predictors of drug-related problems. Hence, to overcome these problems, clinical pharmacists, physicians, and other health professionals have to work in collaboration.

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“…Rational use of medicine (RUM) is a priority for the use of drugs that are following guaranteed safety quality and are available in the community [8]. Inappropriate treatment can cause problems in drug use [9]. One of them is [10], [11].…”

Section: Introductionmentioning

confidence: 99%

Health belief model and the understanding of rational use of medicines

Arimbawa¹,

Hita²,

Wardhana³

2021

IJPHS

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Community perception is an experience that causes a different understanding of treatment. Differences in people's perceptions of drug safety will affect their attitudes towards rational use of medicines (RUM). Therefore, it is necessary to do an in-depth measurement of public perceptions. The purpose of this study was to determine the relationship between community perceptions through the health belief model (HBM) with the understanding of (RUM). This study used a cross-sectional design with 97 samples in Denpasar City, Bali, Indonesia. Data collection was conducted from November 2019 to January 2020 using a questionnaire and analyzed using binary logistic tests. The results showed that perceptions based on perceived susceptibility perceived severity, health motivation, perceived benefits, and self-efficacy did not provide a significant relationship with the understanding of RUM (p>0.05). Perceived barriers provide significant results on the understanding of RUM (p<0.05). Health perceptions in allergy reporting and awareness of drug use based on clinical conditions and selection of alternatives increase understanding of rational drug use. The drug-taking procedure needs to be done quickly and according to the provisions to appropriately use the medication. Therefore, health workers' role is essential in providing complete services and information about drugs in health care, especially in symptomatic drugs.

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Pharmacist intervention in drug-related problems for patients with cardiovascular diseases in selected community pharmacies in Northern Cyprus

Cited by 14 publications

References 11 publications

Drug-related problems and associated factors in Ethiopia: a systematic review and meta-analysis

Drug-related problems and associated factors in Ethiopia: a systematic review and meta-analysis

Drug-related problems and its predictors among hospitalized heart failure patients at Jimma Medical Center, South West Ethiopia: prospective interventional study

Health belief model and the understanding of rational use of medicines

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