Pharmacodynamic and Metabolomics Studies on the Effect of Kouyanqing Granule in the Treatment of Phenol-Induced Oral Ulcer Worsened by Sleep Deprivation

Chen, Pan; Yao, Hongliang; Sui, Weiwei; Zheng, Yonghua; Fan, Weiyang; Zhang, Liping; Chen, Tingting; Wu, Shuling; Zhang, Weijian; He, Yan; Yan, Zenghao; Wang, Yangang; Li, Peibo

doi:10.3389/fphar.2020.00824

Cited by 16 publications

(15 citation statements)

References 63 publications

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“…The serum level of TGF-β was also significantly higher in the group treated with Ganoderma lucidum extract, compared to the control group ( 42 ). TNF-α expression was significantly lower in ulcers treated with extracts of Chamomilla recutita, Salvadora persica and Koyanqing Granule formula, compared to controls ( 30 , 32 , 44 ). VEGF expression was significantly lower in ulcers treated with Salvadora persica extract and higher in ulcers treated with propolis extract, compared to their respective controls ( 30 , 37 ).…”

Section: Resultsmentioning

confidence: 83%

“…The expression of MMP-9 was significantly lower in the ulcers treated with propolis extract, compared to the control group ( 37 ). Serum levels of IL-1β, IL-6, IL-18 were significantly reduced in the group treated with Kouyaqing Granule formula compared to the control group ( 32 ).…”

Section: Resultsmentioning

confidence: 85%

“…The extracts used to treat oral ulcers were herbal ( 34 , 35 , 39 , 42 , 43 , 45 - 48 ), the fungus Ganoderma lucidum ( 40 ), propolis ( 37 ) and curcumin ( 33 , 44 ). The plants used were of the species Musa acuminate ( 34 , 42 ), Aloe barbadensis Miller ( 45 , 38 , 48 ), Matricaria / Chamomilla recutita ( 42 ), Malva sylvestris ( 46 ), Piper sarmentosum ( 35 ), Jasminum grandiflorum ( 31 ), Ficus deltoidea ( 41 ), Salvadora persica ( 30 ), Cannabis sativa ( 38 ), Bletilla striata ( 36 ) and the herbal formula, Kouyanqing Granule (KYQG) ( 32 ).…”

Section: Resultsmentioning

confidence: 99%

“…The physiopathology of oral ulcers is complex and comprises vasodilatation, cytokine production, cell death, and tissue repair and remodelling ( 50 ). Observations at the molecular level include over-expression of VEGF; over-expression of BAX; marked deposit of collagen fibers in the repair process ( 30 , 37 ); and an increase in both pro-inflammatory and anti-inflammatory cytokines ( 30 , 32 , 37 , 40 , 43 , 48 ). The 84% of the studies selected reported a positive effect of the treatments on the variables evaluated.…”

Section: Discussionmentioning

confidence: 99%

“…Extract of Malva sylvestris at 20% produced no significant reduction in the area of the oral ulcer, and no positive effect on re-epithelialization of the palatal mucosa in comparison with the control group treated with placebo ( 46 ). Extracts of Jasminum grandiflorum ( 29 ), Bixina orellana ( 45 ), Musa acuminata stem ( 32 , 40 ), Bletilla striata ( 34 ), curcumin ( 42 ), Ficus deltoidea , and Pi per sarmentosum were effective in accelerating the repair process; authors observed greater contraction of the ulcer, greater re-epithelialization ( 31 , 31 , 44 , 47 ), greater production of factors which accelerate cicatrisation ( 34 ), less severe inflammation ( 37 ), and better healing rates on days 7 ( 36 , 44 ) and 14 ( 44 ). The results with no significant differences obtained by Kovalik et al .…”

Section: Discussionmentioning

confidence: 99%

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Effects of natural extracts in the treatment of oral ulcers: A systematic review of evidence from experimental studies in animals

et al. 2021

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Background To evaluate the clinical and histopathological effects of natural extracts in the treatment of oral ulcers induced in animal experimental models. Material and Methods We carried out a search in the Medline, Scopus, WoS and Embase databases from the start of the databases to December 2020, and also made a manual search of the references. The search and selection were carried out by two researchers independently. The inclusion criteria were: experimental studies in animal models, in english, which complied with the study object. Results A total of 705 articles were identified. After selection by title, abstract and full text, 19 articles were finally included. Natural extracts of Jasminum grandiflorum , Ficus deltoidea , curcumin and Bixina orellana provoked a significantly greater reduction in the size of the ulcer. Extracts of Salvatora persica , Musa acuminate , Ganoderma lucidum mycelia and Bixina Orellana , as well as preparations of Kouyanqing Granule and curcumin, were able to reduce levels of pro-inflammatory cytokines and increase the expression and serum levels of growth factors and anti-inflammatory cytokines. Extracts of Piper sarmentosus , Cannabis sativa and Bletilla striata provoked a reduction in the severity of the histological inflammation. No significant differences were observed compared to controls in the treatments with extracts of Cannabis sativa , Aloe barbadensus Miller and Malva sylvestris in reducing the area of the oral ulcers. Conclusions Most of the natural extracts described in this review presented a positive clinical and histological effect on the cicatrisation of oral ulcers induced in animal models. Key words: Recurrent aphthous stomatitis, oral ulcer, plants, herbs, extracts, medicine, treatment.

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