Pharmacodynamics and enantioselective pharmacokinetics of carprofen in the cat

Taylor, PM; Delatour, P.; Landont, F.M; Deal, C; Pickett, Cheryl A.; Aliabadi, F. Shojaee; Foot, R.; Lees, P.

doi:10.1016/s0034-5288(96)90009-0

Cited by 83 publications

(97 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Therapeutic concentrations of carprofen in plasma are 10-17 μg/mL for dogs, 28 7 μg/mL for cats 29 and >1.5 μg/mL for horses. 30 The average carprofen concentrations measured in the current study 2 h after administration ranged from 30 to 80 μg/mL.…”

Section: Discussionmentioning

confidence: 99%

Randomised trial of the bioavailability and efficacy of orally administered flunixin, carprofen and ketoprofen in a pain model in sheep

Marini

Pippia²,

Colditz

et al. 2015

Aust Veterinary J

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

Randomised trial of the bioavailability and efficacy of orally administered flunixin, carprofen and ketoprofen in a pain model in sheep

Marini

Pippia²,

Colditz

et al. 2015

Aust Veterinary J

View full text Add to dashboard Cite

show abstract

“…36 It has high plasma concentration in cats, achieving levels from 25 to 50 mg/L after administration of a low dose of 4 mg/kg during the first 7 h. 37 However, in dogs, the plasma levels were inferior (between 2 and 15 mg/L) for the same dose. 38 In humans, the plasma levels after a single oral dose of 150 mg rose to 10 mg/L during the first 5 h after administration.…”

Section: Discussionmentioning

confidence: 99%

Antitubercular specific activity of ibuprofen and the other 2-arylpropanoic acids using the HT-SPOTi whole-cell phenotypic assay

et al. 2013

View full text Add to dashboard Cite

ObjectivesLead antituberculosis (anti-TB) molecules with novel mechanisms of action are urgently required to fuel the anti-TB drug discovery pipeline. The aim of this study was to validate the use of the high-throughput spot culture growth inhibition (HT-SPOTi) assay for screening libraries of compounds against Mycobacterium tuberculosis and to study the inhibitory effect of ibuprofen (IBP) and the other 2-arylpropanoic acids on the growth inhibition of M tuberculosis and other mycobacterial species.MethodsThe HT-SPOTi method was validated not only with known drugs but also with a library of 47 confirmed anti-TB active compounds published in the ChEMBL database. Three over-the-counter non-steroidal anti-inflammatory drugs were also included in the screening. The 2-arylpropanoic acids, including IBP, were comprehensively evaluated against phenotypically and physiologically different strains of mycobacteria, and their cytotoxicity was determined against murine RAW264.7 macrophages. Furthermore, a comparative bioinformatic analysis was employed to propose a potential mycobacterial target.ResultsIBP showed antitubercular properties while carprofen was the most potent among the 2-arylpropanoic class. A 3,5-dinitro-IBP derivative was found to be more potent than IBP but equally selective. Other synthetic derivatives of IBP were less active, and the free carboxylic acid of IBP seems to be essential for its anti-TB activity. IBP, carprofen and the 3,5-dinitro-IBP derivative exhibited activity against multidrug-resistant isolates and stationary phase bacilli. On the basis of the human targets of the 2-arylpropanoic analgesics, the protein initiation factor infB (Rv2839c) of M tuberculosis was proposed as a potential molecular target.ConclusionsThe HT-SPOTi method can be employed reliably and reproducibly to screen the antimicrobial potency of different compounds. IBP demonstrated specific antitubercular activity, while carprofen was the most selective agent among the 2-arylpropanoic class. Activity against stationary phase bacilli and multidrug-resistant isolates permits us to speculate a novel mechanism of antimycobacterial action. Further medicinal chemistry and target elucidation studies could potentially lead to new therapies against TB.

show abstract

“…A single injection of carprofen may be safe in cats. 53,54 However, studies are necessary to evaluate the perioperative use of carprofen in cats with traumatic injuries. dd.…”

Section: Discussionmentioning

confidence: 99%

Effects of preoperative administration of carprofen on renal function and hemostasis in dogs undergoing surgery for fracture repair

Bergmann

Nolte²,

Krämer³

2005

ajvr

View full text Add to dashboard Cite

show abstract

Pharmacodynamics and enantioselective pharmacokinetics of carprofen in the cat

Cited by 83 publications

References 23 publications

Randomised trial of the bioavailability and efficacy of orally administered flunixin, carprofen and ketoprofen in a pain model in sheep

Randomised trial of the bioavailability and efficacy of orally administered flunixin, carprofen and ketoprofen in a pain model in sheep

Antitubercular specific activity of ibuprofen and the other 2-arylpropanoic acids using the HT-SPOTi whole-cell phenotypic assay

Effects of preoperative administration of carprofen on renal function and hemostasis in dogs undergoing surgery for fracture repair

Contact Info

Product

Resources

About