Pharmacoeconomic Evaluation of Rufinamide Use for the Lennox-Gastaut Syndrome Treatment

Mazina, N. K.; Mazin, Pavel; Kislitsin, Yu. V.; Markova, E. M.

doi:10.17749/2070-4909.2016.9.1.015-022

Cited by 2 publications

(1 citation statement)

References 7 publications

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“…), а также в ряде случаев -хирургическое лечение [8][9][10]. Противоэпилептические лекарственные средства снижают возбудимость нейронов эпилептического очага, стабилизируют мембранные потенциалы этих клеток, что приводит к уменьшению количества спонтанных разрядов и, соответственно, к снижению количества приступов [11][12][13]. Хирургия направлена на удаление патологически функционирующих участков коры больших полушарий головного мозга, которые являются источником аномальных электрических импульсов, приводящих к судорогам [10,14].…”

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Cell Therapy of Epilepsia. Clinical and Immunological Aspects

Dokukina¹,

Потапнев²,

Kosmacheva³

et al. 2018

Èpilepsiâ paroksizmalʹnye sostoâ.

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Cell Therapy of Epilepsia. Clinical and Immunological Aspects

Dokukina¹,

Потапнев²,

Kosmacheva³

et al. 2018

Èpilepsiâ paroksizmalʹnye sostoâ.

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Recommendations of the Russian League Against Epilepsy (RLAE) on the use of magnetic resonance imaging in the diagnosis of epilepsy

Блинов¹,

Alikhanov

Perepelova

et al. 2019

Èpilepsiâ paroksizmalʹnye sostoâ.

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Introduction. The MRI method has revolutionized the diagnosis of epilepsy. However, the widespread adoption of MRI in clinical practice is slowed by an insufficient number of high-field MRI scanners, a shortage of trained specialists, and the lack of standard examination protocols. The aim of this article is to present the Recommendations of the Russian League Against Epilepsy (RLAE) on the use of magnetic resonance imaging in the diagnosis of epilepsy.Materials and methods. As a structural element of the International League Against Epilepsy (ILAE), the RLAE considers it important to adapt the Protocol developed by ILAE for specialists in Russia and EAEU countries. The working group analyzed and generalized the clinical practice existing in the Russian Federation, the Republic of Kazakhstan, the Republic of Belarus and the Republic of Uzbekistan. These recommendations are intended for doctors in specialized centers of epilepsy surgery, and for doctors in general medical centers. The recommendations are applicable primarily to adult patients, but the general principles are relevant to children as well.Results. In all patients with convulsive seizures shortly after the first seizure, or patients diagnosed with epilepsy who have an unexplained increase in the frequency of seizures, rapid decrease in cognitive functions or the appearance / worsening of neuropsychiatric symptoms, the RLAE recommends using a unified MR protocol for the neuroimaging of structural sequences in epilepsy with three-dimensional pulse sequences T1 and T2 FLAIR with isotropic voxel 1 × 1 × 1 mm3 and two-dimensional T2- weighted pulse sequences with a pixel size of 1 × 1 mm2 or less. The MRI examination should be combined with EEG or EEG-video monitoring. Using this protocol allows one to set a unified standard for examining patients with epilepsy in order to detect (with high sensitivity) brain lesions playing a key role in the occurrence of seizures. Here, all 13 recommendations are presented.Conclusion. Implementation of these recommendations in clinical practice will improve the access to high-tech medical care and optimize health care costs.

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Pharmacoeconomic Evaluation of Rufinamide Use for the Lennox-Gastaut Syndrome Treatment

Cited by 2 publications

References 7 publications

Cell Therapy of Epilepsia. Clinical and Immunological Aspects

Cell Therapy of Epilepsia. Clinical and Immunological Aspects

Recommendations of the Russian League Against Epilepsy (RLAE) on the use of magnetic resonance imaging in the diagnosis of epilepsy

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