Pharmacoepidemiological study of antipsychotics in the psychiatry unit of a tertiary care hospital: A retrospective descriptive analysis

Background: A mental disorder or psychiatry disorder is a behavioural or mental pattern that causes significant distress or impairment of personal functioning. Schizophrenia is one of the most common psychiatric disorders. Aim of the study is to study drug utilization pattern in schizophrenia patients in outpatient department of psychiatry.Methods: A prospective and observational study was conducted in psychiatry outpatient department between May 2018 to October 2018 at Government Medical College and Hospital Aurangabad. Approval from ethics committee was taken. Data collected was of age, sex, final diagnosis, drugs prescribed to patients from case report form. The data obtained was then analyzed in Microsoft excel.Results: Total prescriptions of 129 patients were analyzed. Out of 129 patients 99 (76.74%) were male, while 30 (23.26%) were female. The mean age of the patients admitted in Psychiatry OPD was 36.71±11.76 years. Number of drugs prescribed per patient being 3.40±1.12 (mean±SD). The most common drugs used were olanzapine (66.6%), trihexyphenidyl (51.9%), lorazepam (44.9%), risperidone (39.5%), trifluoperazine (27.9%).Conclusions: Our study shows that atypical antipsychotics were the most common drugs prescribed in patients. Olanzapine was the most common medication used followed by risperidone. Our prospective study is carried out to get a more comprehensive data so that we can improve the drug utilization in our hospital.

Section: Discussionsupporting

confidence: 52%

Drug utilization study in schizophrenia patients in outpatient department of psychiatry: an observational prospective study

Hivale

Kulkarni

Athawale

2020

“…In a pharmacoepidemiological study of antipsychotics conducted by Lahon K et al derived conclusions that average number of drugs per prescription was 2.19, percentage of antipsychotic drugs prescribed by generic name was 63.64%, percentage of encounters with an injection prescribed was 3.03%, percentage of drugs prescribed from WHO essential medicines list was 3.03%. 20 In order to rationalise the drug use, it is important to determine the cost analysis. 21,22 Average drug cost per encounter was determined by dividing total costs of all drugs prescribed by the number of encounters surveyed which was Rs.…”

Section: Discussionmentioning

confidence: 99%

Drug utilization pattern in Schizophrenia

Munjely

Nair

Punnoose³

2019

Background: Pharmacotherapy is the mainstay of treatment in schizophrenia. The economic impact of this illness is wide ranging, long lasting and huge. The emergence of newer antipsychotics has changed the prescribing pattern. Purpose of this study is to determine the prescription pattern of antipsychotic drugs and to analyse the drug utilization in patients with schizophrenia based on WHO prescribing indicators.Methods: A descriptive study was conducted for a period of 1-year duration at inpatient Department of Psychiatry of a Government Medical College in Kerala, India among 230 schizophrenic patients. The case sheets of patients meeting inclusion criteria were scrutinised to find out the antipsychotic prescription pattern and drug utilization was analysed using WHO prescribing indicators. Analysis was done using descriptive statistics.Results: Newer antipsychotics (55.2%) were prescribed slightly more in preference to older antipsychotic (44.8%) drugs. Out of the newer drugs prescribed olanzapine (20.9%) was prescribed the most followed by risperidone (18%). Haloperidol (22.9%) was the most frequently prescribed older antipsychotic. Majority (71.3%) of the patients were given more than one antipsychotics during the hospital stay. Trihexyphenidyl (27.9%) was the most frequently co-prescribed drug with antipsychotics. Average number of drugs per encounter was 4.19, 73.4% of the drugs were prescribed in their generic name, 50.4% of the encounters were with an injection prescribed. 44.4%of the drugs were prescribed from the EDL (WHO-19th edition). Average drug cost per encounter was Rs.45.43. Percentage of drug cost spent on injections was 8.44%.Conclusions: Newer antipsychotics were more prescribed for schizophrenia of which olanzapine was the commonest. Newer antipsychotics are preferred because of their propensity to cause less side effects and more efficacy. Study of pattern of drug utilization is useful for measuring the economic impact of drug use among patients thereby facilitating rational prescribing.

“…Atypical antipsychotic drugs were the most common prescribed which is similar to other studies. [10][11][12][13] Atypical antipsychotic are now rated as the first-line agents for the treatment of mania because of their low propensity to cause extrapyramidal side effects, efficacy against refractory cases, and better control over negative symptoms. In our study, the prescribing frequency of central anticholinergic, anti-Parkinsonian drug trihexyphenidyl HCL is 43.75%.…”

Section: Frequency Of Psychotropic Drug Usage In Major Depressionmentioning

confidence: 99%

Drug utilization study of psychotropic drugs in outdoor patients in a tertiary care hospital attached with a medical college

Doshi¹,

Hedamba²,

Darji³

et al. 2015

Drug utilization study has been defined by the World Health Organization (WHO) as "The marketing, distribution, prescription and uses of drugs in a society with special emphasis on the resulting medical and social and economic consequences." 1 The interests in drug utilization studies were generated as a result of: (1) number of new drug marketed, (2) wide variations in the prescribing pattern, (3) growing concern about delayed adverse effects, (4) increasing concern about the cost of drug as reflected by increase in both sales and the volume of prescription drugs. 2 Psychiatric disorders form an important public health priority. 3 Of the top 10 health conditions contributing to the disability-adjusted life years, four are psychiatric disorders. Mental illness is associated with high levels of health service utilization and associated costs and in developing countries these costs are mostly paid by the patient. 4 The present study was undertaken to analyze the pattern of drug utilization of psychotropic medications in outdoor patients of psychiatry department of a tertiary care teaching hospital in Jamnagar. METHODS A cross-sectional, prospective drug utilization study was carried out in outdoor patient of Psychiatry Department of Guru Gobind Singh Government Hospital, a tertiary care ABSTRACT Background: Psychotropic drugs have a great importance in psychiatric practice. Today many newer drug like selective serotonin reuptake inhibitors and atypical antipsychotic drugs has changed treatment protocol. Hence, the study was carried out to find morbidity pattern of psychiatric illness and prescribing pattern of psychiatric illness. Methods: A prospective cross-sectional study was carried out for 12 months. Patients of all ages and both sexes were included in the study while inpatients and referred patients were excluded. The prescribing pattern was analyzed by using World Health Organization (WHO) basic drug indicators. Results: Among 600 patients, male patient were 291 (48.50%) and female patient were 309 (51.50%). The most common disorder was depression 208 (34.66%) followed by schizophrenia 192 (32.00%). The numbers of psychotropic drugs prescribed a patient were 2.51. 39.39% drugs were prescribed from the WHO essential medicines list. Total 89.18% drugs were prescribed by generic name. Benzodiazepines were the most common prescribed drugs. Atypical antipsychotic drugs were commonly used than typical antipsychotic drugs. Central anticholinergic drug was used in 43.15% patients receiving antipsychotic drugs. Conclusion: Overall, the drugs were prescribed rationally. Benzodiazepine should be prescribed only for short-term duration. Use of central acting anticholinergic drugs with all antipsychotic drugs was not justified.