Pharmacogenetics - Getting Closer

MacDonald, Ian M.

doi:10.2174/1874364100903010046

TOOPHTJ

2009

DOI: 10.2174/1874364100903010046

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Pharmacogenetics - Getting Closer

Ian M. MacDonald¹

Abstract: This review is written for the generalist to provide an understanding of the application of genetics to the care of patients with glaucoma and the broader concepts of personalized medicine. More specifically, the review will link advances in the genetics of glaucoma with the concepts of pharmacogenetics and its potential to improve patient care.

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Genetic diversity and medicinal drug response in eye care

Shastry

2010

Graefes Arch Clin Exp Ophthalmol

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These studies are still in their infancy, and do not suggest that a pharmacogenetic basis of drug development is a credible concept and can become reality in the future. This is because most drug responses involve a large number of genes that have several polymorphisms and it is unlikely that any one single gene dictates the drug response. Therefore, a polygenic approach, whole genome single nucleotide polymorphism (SNP) analysis and a molecular understanding of disease itself may provide a better insight in the future about genetic predisposing factors for adverse drug reactions.

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Genetic diversity and medicinal drug response in eye care

Shastry

2010

Graefes Arch Clin Exp Ophthalmol

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Re: Analysis of the Publication Volume of Canadian Ophthalmology Departments from 2005 to 2009: A Systematic Review of the Literature

Rudnisky¹,

Damji²,

Tennant³

et al. 2011

Canadian Journal of Ophthalmology

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Pharmacogenetics - Getting Closer

Cited by 2 publications

References 24 publications

Genetic diversity and medicinal drug response in eye care

Genetic diversity and medicinal drug response in eye care

Re: Analysis of the Publication Volume of Canadian Ophthalmology Departments from 2005 to 2009: A Systematic Review of the Literature

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