Pharmacogenetics of opioid analgesics in dogs

Kongara, Kavitha

doi:10.1111/jvp.12452

Cited by 12 publications

(13 citation statements)

References 114 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Reviews on the use of opioids in dogs and cats including clinical guidance, and misconceptions and controversies related to opioid analgesia are recommended as further reading (Steagall et al . 2014, Bortolami & Love 2015, Simon & Steagall 2017, Kongara 2018).…”

Section: Sectionmentioning

confidence: 99%

“…Prevalence of rescue analgesia was higher in the control group (n=15/15) than the multi-modal group (n=1/14) (Malo et al 2022). Reviews on the use of opioids in dogs and cats including clinical guidance, and misconceptions and controversies related to opioid analgesia are recommended as further reading (Steagall et al 2014, Bortolami & Love 2015, Simon & Steagall 2017, Kongara 2018).…”

Section: Special Considerationsmentioning

confidence: 99%

See 1 more Smart Citation

2022 WSAVA guidelines for the recognition, assessment and treatment of pain

Monteiro

Lascelles

Murrell

et al. 2022

J of Small Animal Practice

View full text Add to dashboard Cite

Animal sentience refers to the capacity of animals to feel both positive and negative emotions including that of pain. As veterinary health professionals, we have a medical and ethical duty to mitigate suffering from pain to the best of our ability. In 2014, the first Global Pain Council World Small Animal Veterinary Association (WSAVA) Guidelines for the Recognition, Assessment and Treatment of Pain was published and remains to this day one of the most relevant and widespread documents of its kind. The 2022 WSAVA Global Pain Management Guidelines evolves from the first document with updated scientific information reflecting major advances in veterinary pain medicine in the last decade. This document is designed to provide the user with easy-to-implement, core fundamentals on the successful recognition and treatment of pain in the day-to-day small animal clinical practice setting. It provides basic and practical information with an extensive reference list to guide those who want to further their knowledge on pain management. The 2022 WSAVA Global Pain Management Guidelines should be easily implemented regardless of practice setting and/or location for the promotion and advance of pain management and animal welfare. FIG 4. Peripheral sensitisation results in increased sensitivity around the lesion site. Affected patients may exhibit signs of hyperalgesia and allodynia. Adapted from Monteiro & Simon (2022). PGs Prostaglandins, NGF Nerve growth factor FIG 5. The constant noxious input (electrical signal) from the periphery to the spinal cord results in central sensitisation. Central sensitisation is the result from increased pain facilitation and decreased pain inhibition. Neuroplasticity and neuroimmune interactions also contribute to this phenomenon

show abstract

Section: Sectionmentioning

confidence: 99%

Section: Special Considerationsmentioning

confidence: 99%

2022 WSAVA guidelines for the recognition, assessment and treatment of pain

Monteiro

Lascelles

Murrell

et al. 2022

J of Small Animal Practice

View full text Add to dashboard Cite

show abstract

“…In addition to anatomical differences, breed-specific drug idiosyncrasies have been reported. One such example is the report of opioid-induced dysphoria in certain breeds of dogs (Table 3) (Kongara 2018). Likewise, in Alaskan breeds, increased opioid sensitivity has been observed, and revising of the dose rates in these dogs may be warranted (Kongara 2018).…”

Section: Performing Thorough Preanaesthetic Assessments In Dogs and Catsmentioning

confidence: 99%

Preanaesthetic screening in dogs and cats

Ferreira¹

2020

In Practice

View full text Add to dashboard Cite

Background: Preparation before performing general anaesthesia is essential. In order to comprehensively plan and execute safe anaesthesia, it is vital to quantify anaesthetic risk. However, currently there is limited veterinary literature that collates anaesthetic-related, patient-related and procedural-related risks.Aim of the article: This article highlights previously reported perioperative factors contributing to morbidity and mortality in small animals, as well as important considerations to factor in based on the patient history and findings on clinical examination. It also discusses the current opinions on blood screening and diagnostic imaging.

show abstract

“…Regional analgesic methods are a very attractive form of perioperative analgesia, as many of the side effects of systemic opioid analgesics can be avoided or decreased (Carpenter et al., 2004 ; Wolfe et al., 2006 ; Abelson et al., 2009 ; Lemke & Dawson, 2000 ). Opioids have traditionally been the analgesic class used most commonly for orthopaedic surgery but are known to cause undesirable postoperative side effects such as dysphoria (Becker et al., 2013 ; Kongara, 2018 ), gastrointestinal dysfunction such as ileus (Brock et al., 2012 ; Johnson, 1981 ), disruption of temperature regulation (Adler et al., 1988 ) and even adverse immunomodulatory effects (Odunayo et al., 2010 ). Consequently, efficacious and safe alternatives for postoperative analgesia are continuously sought in veterinary medicine.…”

Section: Introductionmentioning

confidence: 99%