Pharmacognostical Evaluation and HPTLC Fingerprinting Identification of Ficus palmata Forssk. (Bedu) from Western Himalaya

Tewari, Devesh; Sah, Archana N.; Bawari, Sweta; Sharma, Himanshu; Mangal, Anupam K

doi:10.2174/1573407213666170126161111

Cited by 7 publications

(4 citation statements)

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“…The HPLC results clearly revealed the presence of psoralen in the hydroalcoholic extract of F. palmata. We have also reported a detailed analysis of the extracts of F. palmata by HPTLC and UPLC-MS [ 19 , 20 ] and found that multiple compounds like elagic acid, psoralen, gallic acid aliphatic and aromatic carboxylic acids, along with many flavonoids, were found in the F. palmata extracts.…”

Section: Resultsmentioning

confidence: 99%

Himalayan Ficus palmata L. Fruit Extract Showed In Vivo Central and Peripheral Analgesic Activity Involving COX-2 and Mu Opioid Receptors

Tewari

Gupta

Bawari

et al. 2021

Plants

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Analgesic drugs like morphine and non-steroidal anti-inflammatory drugs exhibit several harmful effects. Here, we show for the first time the analgesic activity of Ficus palmata L. fruit extract (FPFE) on different analgesic rat models along with the in silico studies of some of the main phytochemicals of this plant. We performed in vivo pain models, along with in silico docking studies against the active site of COX-2 protein and mu-opioid receptors. A significant (p < 0.05) analgesic effect of FPFE was observed, and it was found that rutin has good pose and score as compared to diclofenac and morphinan antagonist (X-ligand), and psoralen has binding affinity almost equal to diclofenac, but a lower binding affinity as compared to rutin. The results proved that F. palmata fruits have the potential to ameliorate painful conditions.

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Section: Resultsmentioning

confidence: 99%

Himalayan Ficus palmata L. Fruit Extract Showed In Vivo Central and Peripheral Analgesic Activity Involving COX-2 and Mu Opioid Receptors

Tewari

Gupta

Bawari

et al. 2021

Plants

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“…The SEM photographs were captured on the Zeiss EVO 50 scanning electron microscope at the required magnification (ranging between 100x to 8000x) at room temperature. 13 …”

Section: Scanning Electron Microscopymentioning

confidence: 99%

“…This technique is proving as one of the most exciting and momentous tool for the study and elevation of surface topography of solids. 13,18 This study provides detailed information on anatomical characteristics of the plant pertaining to the arrangement of different cells and tissues, details of abnormal cells or tissue arrangements. 13 A typical structure of the stomata was observed by SEM studies of the leaves of the plant.…”

Section: Scanning Electron Microscopymentioning

confidence: 99%

Pharmacognostical Evaluation of Rhododendron arboreum Sm. from Uttarakhand

Tewari¹,

Sah²,

Bawari³

2018

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Objective: Rhododendron arboreum Sm. commonly known as Burans is an important plant of the Himalayan region. It is the national flower of Nepal and state tree of Uttarakhand. The present study pertains to the pharmacognostical evaluation of R. arboreum from Uttarakhand. Methods: Macroscopy, microscopy by free hand section cutting and with the help of scanning electron microscopy (SEM) were done along with the physicochemical analysis. Preliminary phytochemical studies and fluorescence analysis was also carried out. Results: Results revealed that the leaves contain paracytic or amphiparacytic stomata in cluster form. The epidermal cells were long and spongy. The cells also contain some grooves and papillae throughout the surface. Preliminary phytochemical analysis showed the presence of different secondary metabolites like alkaloids carbohydrates, phenols, proteins, saponins, and tannins. Conclusion: R. arboreum from Uttarakhand region was investigated for its morphological and cytological characteristics with the help of scanning electron microscopy for the first time. The results provide details on the presence of several specific characters which are important for the identification of the genuine crude drug.

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“…F. palmata is used to cure many diseases, including tumors, fungal infections, gastrointestinal disorders, diabetes, ulcers, hypoglycemia, and hyperlipidemia [4]. By using liquid-liquid fractionation and various chromatographic techniques, the phytochemical screening of the F. palmata plant extract contains alkaloids, tannins, flavonoids, terpenoids, and cardiac glycosides [5]. The aerial parts of the F. palmata contain one triterpene (germanicol acetate), two furanocoumarins (psoralene and bergapten), one aromatic acid (vanillic acetate), and the flavone glycoside rutin [6].…”

Section: Introductionmentioning

confidence: 99%

In vitro evaluation of the cytotoxic potential of Ficus palmata and its combination with chemotherapy and photodynamic therapy

Aziz¹,

Khurshid²,

Ahmat³

et al. 2023

Laser Phys. Lett.

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Ficus palmata (F. palmata) is a medicinally very rich plant that is used as a folk medicine to treat many diseases. This study investigated the anticancer effect of 70% ethanolic leaves extract of F. palmata alone and its combinational study with photosense-mediated photodynamic therapy (PDT) and doxorubicin hydrochloride (Dox-HCl) on rhabdomyosarcoma (RD) cells. The inhibitory dose (IC50) was calculated from dose response analysis of 24 h post exposure of F. palmata (400, 200, 100, 50, 25, 12.5 µg ml−1), Dox-HCl (4, 3, 2, 1 µM), and photosense (80, 40, 20, 10, 5 µM, 10 J cm−2) mediated PDT. These IC50 doses were further used to assess the anticancer effect of F. palmata in combination with photosense-mediated PDT and Dox-HCl. The in vitro findings showed that the 70% ethanolic F. palmata leaves extract has anticancer potential, and has the ability to enhance the anticancer effect in combination with other therapies. Moreover, the neoadjuvent combination of F. palmata with PDT and chemotherapy has a synergistic effect. This study provides evidence that F. palmate leaves extract possesses promising anticancer activity, and more research is needed to isolate the specific bioactive compound for cancer treatment.

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Pharmacognostical Evaluation and HPTLC Fingerprinting Identification of Ficus palmata Forssk. (Bedu) from Western Himalaya

Cited by 7 publications

References 0 publications

Himalayan Ficus palmata L. Fruit Extract Showed In Vivo Central and Peripheral Analgesic Activity Involving COX-2 and Mu Opioid Receptors

Himalayan Ficus palmata L. Fruit Extract Showed In Vivo Central and Peripheral Analgesic Activity Involving COX-2 and Mu Opioid Receptors

Pharmacognostical Evaluation of Rhododendron arboreum Sm. from Uttarakhand

In vitro evaluation of the cytotoxic potential of Ficus palmata and its combination with chemotherapy and photodynamic therapy

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