Pharmacognostical Evaluation of Fruits of Solanum lycocarpum A. St.-Hill. (Solanaceae)

Araújo, Marcelo Gonzaga Freitas; Galeane, Mariana Cristina; Castro, André Luís da Silva; Salgado, Hérida Regina Nunes; Almeida, Adélia Emília de; Cunha, Wilson Roberto; Veneziani, Rodrigo Cássio Sola; Moreira, Raquel Regina Duarte

doi:10.1016/s0975-3575(10)80112-9

Cited by 6 publications

(6 citation statements)

References 18 publications

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“…Phytochemical studies have shown that Solanum lycocarpum fruit contain different classes of compounds, such as: phenols and tannins [ 22 ]; glycoalkaloids as solamargine, solasonine, 12-hydroxysolasonine, robeneoside A, and robeneoside B [ 7 ], as well as lobofrutoside and saponins, as lyconoside Ia, Ib, II, III, and IV [ 23 ]. However, this method has been developed for the glycoalkaloids solasonine and solamargine, not only because they are major compounds in Solanum lycocarpum fruits, but also because of their potential importance for the development of new pharmaceuticals.…”

Section: Resultsmentioning

confidence: 99%

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A Validated Reverse Phase HPLC Analytical Method for Quantitation of Glycoalkaloids inSolanum lycocarpumand Its Extracts

Tiossi

Miranda

Sousa

et al. 2012

Journal of Analytical Methods in Chemistry

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Solanum lycocarpum (Solanaceae) is native to the Brazilian Cerrado. Fruits of this species contain the glycoalkaloids solasonine (SN) and solamargine (SM), which display antiparasitic and anticancer properties. A method has been developed for the extraction and HPLC-UV analysis of the SN and SM in different parts of S. lycocarpum, mainly comprising ripe and unripe fruits, leaf, and stem. This analytical method was validated and gave good detection response with linearity over a dynamic range of 0.77–1000.00 μg mL−1 and recovery in the range of 80.92–91.71%, allowing a reliable quantitation of the target compounds. Unripe fruits displayed higher concentrations of glycoalkaloids (1.04% ± 0.01 of SN and 0.69% ± 0.00 of SM) than the ripe fruits (0.83% ± 0.02 of SN and 0.60% ± 0.01 of SM). Quantitation of glycoalkaloids in the alkaloidic extract gave 45.09% ± 1.14 of SN and 44.37% ± 0.60 of SM, respectively.

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Section: Resultsmentioning

confidence: 99%

“…Phytochemical studies revealed that S. lycocarpum fruits, in addition to the glycoalkaloids, contain tannins and phenolics [ 22 ]. Also, sensorial studies showed that the bitterness or burning associated with the intake of Solanum fruits are related to glycoalkaloid content and not with the phenolic compounds [ 35 ].…”

Section: Resultsmentioning

confidence: 99%

A Validated Reverse Phase HPLC Analytical Method for Quantitation of Glycoalkaloids inSolanum lycocarpumand Its Extracts

Tiossi

Miranda

Sousa

et al. 2012

Journal of Analytical Methods in Chemistry

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“…Thus, in extractions using only water, hot or cold, as extractor liquid, the stability of the extract becomes compromised, and the risk of microbiological contamination increases significantly. This contamination can compromise the quality and integrity of the plant material itself, as well as products arising from its use [54,5]. In addition to extraction temperature, the choice of extraction solvent is another important factor to prevent microbial contamination.…”

Section: Extraction Methodsmentioning

confidence: 99%

Evaluation of microbiological criteria and quality of packaged herbal medicinal products

Onodugo¹,

Obiekezie²,

Owuna³

2023

World J. Adv. Res. Rev.

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The broad use of packaged herbal medicinal products has highlighted many issues associated with the quality, safety, and efficacy (QSE) of these products. Regardless of extensive applications of herbal medicines, this fact cannot be denied that the plant materials are exposed to various contaminants like toxic elements, pesticide residues, insects etc. But the main contaminants responsible for the deterioration of the herbal medicinal products (HMPs) are the microbes. They exert a bad impact on the overall quality and shelf life of the herbal products. The qualities of these products not only revealed changes in the physical appearance but could also pose a risk of acquisition of pathogenic microbial agents such as bacteria spores and mycotoxins to those taking these products. Exposure to these microbial agents can cause adverse health effect and toxicity. The integrity of composition depends upon the harvesting, handling, packaging, distribution, and storage conditions. In absence of good manufacturing practice, however, the nutritional richness of HMPs makes the product good medium for microbial growth, vehicle of microbial pathogens and associated complications. In Nigeria the issues of non-standardization, improper regulation and registration of these herbal products has raised a lot of questions about the inherent health risk associated with the consumption of these products, especially now there is increasing popularity of the use of herbal medicines. This paper addresses microorganisms and their agents as the major contaminants of herbal medicinal products. It reviews precise sources of microbial contamination and harmful effects of contaminated herbal medicinal products, when consumed by the consumers. It also reviews the methodological aspects regarding the influence of different commonly used pharmaceutical preparation techniques on the microbiological criteria of the products. And finally discussed the way forward to ascertain these quality, safety, and efficacy (QSE), of herbal medicinal products, quality standards which could be considered for guidelines and or possible inclusion in herbal pharmacopeia.

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“…Thus, in extractions using only water, hot or cold, as extractor liquid, the stability of the extract becomes compromised and the risk of microbiological contamination increases significantly. This contamination can compromise the quality and integrity of the plant material itself, as well as products arising from its use [29][30].…”

Section: Extraction Methodsmentioning

confidence: 99%

Microbial Quality of Medicinal Plant Materials

Araújo¹,

Bauab²

2012

Latest Research Into Quality Control

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Pharmacognostical Evaluation of Fruits of Solanum lycocarpum A. St.-Hill. (Solanaceae)

Cited by 6 publications

References 18 publications

A Validated Reverse Phase HPLC Analytical Method for Quantitation of Glycoalkaloids inSolanum lycocarpumand Its Extracts

A Validated Reverse Phase HPLC Analytical Method for Quantitation of Glycoalkaloids inSolanum lycocarpumand Its Extracts

Evaluation of microbiological criteria and quality of packaged herbal medicinal products

Microbial Quality of Medicinal Plant Materials

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