Pharmacognosy of Enicostemma littorale: A review

Saranya, Rajamani; Thirumalai, T.; Hemalatha, Munisami; Balaji, Ranganathan; Ernest, David

doi:10.1016/s2221-1691(13)60028-3

Cited by 38 publications

(15 citation statements)

References 21 publications

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“…Enicostemma littorale, a perennial herb, has been used for therapy of diabetes mellitus in India as a folk medicine (Saranya et al 2013). Very recently we also demonstrated that EL MeOH extract possess potential islet neogenic activity from tissue specific stem/progenitor cells, which was later confirmed by identifying the active ingredient swertisin for this islet neogenic potential in a another recent report from us (Dadheech et al 2010(Dadheech et al , 2013.…”

Section: Discussionsupporting

confidence: 58%

“…Enicostemma littorale (EL), a herb of the Gentianaceae family, contains diversified phytochemicals: some of the important constituents of the plant include betulin, a triterpenoid sapogenin, swertiamarin, a secoiridoid glycoside, monoterpene alkaloids like enicoflavine, swertisin, a flavonoid and gentiocrucine (Saranya et al 2013). Also, as described by Ambikapathy et al (2011), some of the major components of the EL MeOH ext.…”

Section: Introductionmentioning

confidence: 99%

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Anti-apoptotic and cytoprotective effect ofEnicostemma littoraleagainst oxidative stress in Islets of Langerhans

Srivastava

Bhatt

Patel

et al. 2016

Pharmaceutical Biology

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Context Oxidative stress induces apoptosis within Islets of Langerhans in diabetes mellitus (DM).Enicostemma littorale blume, herb of the Gentianaceae family is used as an anti-diabetic agent across rural India. Objective This report demonstrates potent anti-apoptotic and cyto-protective activity of Enicostemma littorale MeOH extract (EL MeOH ext.) against 50 mM H 2 O 2 in isolated rat Islets. Materials and methods In this study, the whole plant methanolic extract of EL with doses 0.25-4 mg/mL each for the preincubation duration of 0.5-4 h against 50 mM H 2 O 2 were tested for optimum protective dose and time by Trypan blue dye exclusion assay. Islet intracellular reactive oxygen species (ROS) was quantified by DCFDA staining and cell death using PS/PI & FDA/PI staining. Further, comet assay, biochemical assessment of caspase-3 and antioxidant enzyme activities along with immunoblotting of PARP-1, caspase-3, TNF-a activation and p-P38 MapK (stress kinase) induction was performed. Results The optimized dose of EL MeOH ext. 2 mg/mL for 2 h was used throughout the study, which significantly decreased total Intracellular ROS and cell death. Further, caspase-3 activity, PARP-1 cleavage, p-P38 MapK (stress kinase) activation and TNF-a levels, which had been significantly elevated, were normalized. Antioxidant enzymes like catalase, superoxide dismutase, reduced glutathione and glutathione peroxidase, along with Comet assay, demonstrated that pretreatment with EL MeOH ext. can augment antioxidant enzyme activities and protect from DNA damage. Discussion and conclusions Significant anti-apoptotic and cyto-protective effects were mediated by EL with Islets of Langerhans subjected to oxidative stress-induced cell death. ARTICLE HISTORY

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Section: Discussionsupporting

confidence: 58%

Section: Introductionmentioning

confidence: 99%

Anti-apoptotic and cytoprotective effect ofEnicostemma littoraleagainst oxidative stress in Islets of Langerhans

Srivastava

Bhatt

Patel

et al. 2016

Pharmaceutical Biology

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“…Plant derived medicines are considered to be first line of defense in maintaining health and combating diseases and even today plant source is principal source of new drug of therapeutic property [1] . Approximately 72 000 plant species were estimated for having medicinal properties of which, India recognizes more than 3 000 plant species having medicinal values [2] . Ayurveda is "science of life", pointed out concept of positive health means metabolically wellbalanced human beings.…”

Section: Introductionmentioning

confidence: 99%

Plant profile, phytochemistry and pharmacology of Cordia dichotoma (Indian cherry): A review

Jamkhande

Barde

Patwekar

et al. 2013

Asian Pacific Journal of Tropical Biomedicine

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More than half of the world's population relies on the traditional medicine and major role of the traditional medicine including the use of plant extract and their active constituents. Among them, Cordia dichotoma Forst., a small to moderate size plant of family Boragenaceae, commonly called bhokar, lasura, gonda, Indian cherry and shlesmataka. Plant parts such as leaves, fruit, bark and seed have been reported for possessing antidiabetic, antiulcer, anti-inflammatory, immune-modulator and analgesic activity. Screening of fruit, leaves and seed shows the presence of pyrrolizidine alkaloids, coumarins, flavonoids, saponins, terpenes and sterols. Present review focuses on details of geographical distribution, physicochemical parameters, phytoconstituents and pharmacological properties of Cordia dichotoma reported so far.

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“…Gentamicin treated rats demonstrated antioxidant activity to counteract mitochondrial and in addition post-mitochondrial parts of renal tissues as confirmed by increasing the levels lipid peroxidation and antioxidant enzymes like G-glutathione peroxidase (GPx) and Super oxide dismutase (SOD) (Saranya et al, 2013).…”

Section: Wound Healing Activitymentioning

confidence: 95%

Swertiamarin ointment: A traditional approach in cutaneous wound healing

Ibrahim¹,

Nagarajan²,

Majeed³

2019

Asian J Pharm Pharmacol

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Objective Materials and : To explore the wound healing activity of leaf extract (Gentianaceae). Enicostema littorale Methods: Ethanolic leaf extract and its active secoiridoid, Swertiamarin are used for this study. There is a significant wound healing activity observed for the group of Wistar rats treated with Swertiamarin. Scientific cure is proven by measuring the wound area in each test group animals from 0 to 15 days. : The topical application of ethanolic Results extract and Swertiamarin ointment results in decrease of the wound area in 15 days. Swertiamarin is effective in comparison with crude ethanolic extract. Biological estimation also proved that the Swertiamarin treated group had a high percentage of wound contraction score than the control group. : Swertiamarin formulated herbal Conclusion ointment is an efficient cutaneous ointment for wound healing activity in excision animal models.

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Pharmacognosy of Enicostemma littorale: A review

Cited by 38 publications

References 21 publications

Anti-apoptotic and cytoprotective effect ofEnicostemma littoraleagainst oxidative stress in Islets of Langerhans

Anti-apoptotic and cytoprotective effect ofEnicostemma littoraleagainst oxidative stress in Islets of Langerhans

Plant profile, phytochemistry and pharmacology of Cordia dichotoma (Indian cherry): A review

Swertiamarin ointment: A traditional approach in cutaneous wound healing

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