Pharmacognosy: phytomedicines and their mechanisms

Larkins, N.; Wynn, Susan G.

doi:10.1016/j.cvsm.2003.09.006

Cited by 34 publications

(27 citation statements)

References 90 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Different flavoniods isolated from medicinal plants have shown remarkable antipyretic, analgesic and antiinflammatory activities (Sawadogo et al, 2006;Larkins and Wynn, 2004). The observed antipyretic, the analgesic and anti-inflammatory effects could be attributed to its flavonoids constituent, and this finding supported our recent observation on the stem bark extract of B. buopozense.…”

Section: Discussionsupporting

confidence: 81%

Pharmacological evaluation of the aqueous stem bark extract of Bombax buonopozense in the relief of pain and fever

Essien¹,

Essiet²,

Akuodor³

et al. 2016

Afr. J. Pharm. Pharmacol.

View full text Add to dashboard Cite

Bombax buonopozense is used in traditional medicine in Nigeria for the treatment of pains and feverish conditions. This study was orally carried out to establish the analgesic, anti-inflammatory and antipyretic properties of an aqueous stem bark extract of Bombax buonopozense in experimental animals. The analgesic activity was measured using the acetic acid-induced abdominal constriction and water tail imgmersion tests. The anti-inflammatory activity was assayed using the xylene and carrageenan-induced oedema tests, while the antipyretic activity was measured using the brewer's yeast and 2, 4 dinitrophenol-induced pyrexia. The stem bark extract (50, 100 and 200 mg/kg) at all doses used, was found to have significant (P<0.05) analgesic, anti-inflammatory and anti-pyretic activities. Data shows that aqueous stem bark extract of B. buonopozense possesses constituents with therapeutic potential against pains and feverish conditions, thus supporting the use of the stem bark of this plant for similar ailments in traditional medicine.

show abstract

Section: Discussionsupporting

confidence: 81%

Pharmacological evaluation of the aqueous stem bark extract of Bombax buonopozense in the relief of pain and fever

Essien¹,

Essiet²,

Akuodor³

et al. 2016

Afr. J. Pharm. Pharmacol.

View full text Add to dashboard Cite

show abstract

“…Stigmasterol possesses analgesic and anti-inflammatory activities [38]. One or a combination of the phytoconstituents of D. cordata may be responsible for its different activities observedin this study, especially as synergy is an important concept in the pharmacology of phytochemicals of botanical medicines [39]. Furthermore Previous study reported the safety of oral administration of the aqueous extract of D. cordata based on the fact that no mortality and visible signs of toxicity were recorded on rats given up to 2 g/kg.…”

Section: Discussionmentioning

confidence: 99%

<i>Drymaria cordata</i> (Linn.) Willd (Caryophyllaceae): Ethnobotany, Pharmacology and Phytochemistry

Nono¹,

Nzowa²,

Barboni³

et al. 2014

ABC

View full text Add to dashboard Cite

In the present paper the isolation and characterization of seven major glycolipid classes (stigmasterol, acylated stigmasteryl glucoside, stigmasteryl glucoside, monogalactosyldiacylglycerol, digalactosyldiacylglycerol, cerebroside and glucocerebroside) from Drymaria cordata (Linn.) Willd (Caryophyllaceae Family) are reported after an attempt has been made to congregate the traditional and pharmacological studies done on this important medicinal plant. Drymaria cordata is a weak spreading herb found widely dispersed in damp places all over the tropics of Africa, Asia and the Americas. There are many reports on its folk and traditional uses that include snake bite, skin diseases, peptic ulcer, headaches or nephritis, female infertility, sleeping disorders, convulsions, and febrile conditions in children. The plant has been examined on the basis of scientific in vitro and in vivo evaluations possessing the major pharmacological activities that include analgesic activity, antitussive activity, anxiolytic activity, antipyretic activity, antinociceptive activity, anti-inflammatory and antibacterial activities. The information summarized here is intended to serve as a reference tool for practitioners in the fields of ethnopharmacology, natural product chemistry and drug discovery related research.

show abstract

“…29 Phytochemicals with antioxidant effects include cinnamic acids, coumarins, diterpenes, flavonoids, lignans, monoterpenes, phenylpropanoids, tannins, and triterpenes. 30 Wang et al 31 demonstrated that oleanolic acid (0.1 and 0.2%) and ursolic acid (0.1 and 0.2%) markedly suppressed renal aldose reductase activity and enhanced glyoxalase I activity, which contributed to decrease renal advanced glycation end products formation and improvedd renal functions. The impact of these two triterpenes on mRNA expression of renal aldose reductase and glyoxalase I revealed that the effects of these agents occurred at the transcription level.…”

Section: Discussionmentioning

confidence: 99%

Protective Effects of Ursolic Acid in the Kidneys of Diabetic Rats

Bacanlı¹,

Aydın²,

Anlar³

et al. 2018

tjps

View full text Add to dashboard Cite

Amaç: Metabolik ve kronik bir hastalık olan diyabetin birçok ülkede önemli sağlık sorunu olma durumu artış göstermektedir. Diyabetin artmış serbest radikallerin üretimi ve azalmış antioksidan kapasiteyle ilişkili olduğu iddia edilmektedir. Diyabette oluşan oksiatif stres dokularda DNA hasarına neden olabilir. Antioksidan, antikanser, antiülser özellikler gibi sağlığa yararlı etkileri nedeniyle geleneksel Çin halk tıbbında yaygın olarak kullanılan ursolik asit çok iyi tanımlanmış pentasiklik triterpendir. Bu çalışmanın amacı, streptozotosin ile diyabet oluşturulmuş Wistar albino sıçanların böbreklerine ursolik asidin etkisini değerlendirmektir. Gereç ve Yöntemler: Bu amaçla, böbrek hücrelerindeki DNA hasarı alkali comet yöntemiyle araştırılmıştır. KAT, SOD, GR ve GSH-Px enzim aktiviteleri ve toplam GSH ve MDA düzeyleri gibi oksidatif stres parametreleri de ölçülmüştür. Bulgular: Ursolik asit tedavisinin, DNA hasarını, GR enzim aktivitelerini ve MDA seviyelerini önemli ölçüde azalttığı ve diyabetik sıçanlarda GSH düzeylerini ve CAT, SOD ve GSH-Px enzim aktivitelerini önemli ölçüde artırdığı bulundu. Sonuç: Sonuçlarımıza göre, ursolik asidin diyabetin neden olduğu böbrek hasarında yararlı olabileceği görülmüştür. Anahtar kelimeler: Diyabet, DNA hasarı, oksidatif stres, böbrek Objectives: Diabetes, a heteregenous metabolic and chronic disease, is a growing health problem in most countries. It has been claimed that diabetes is associated with the increased formation of free radicals and decreased in antioxidant potential. Oxidative stress formed in diabetes may cause DNA damage in the tissues. Ursolic acid, a well-known pentacylic triterpene, is commonly used in traditional Chinese medicine due to its beneficial health effects such as antioxidant, anticancer, and antiulcer properties. The aim of this study was to investigate the effects of ursolic acid in the kidneys of Wistar albino rats with streptozotocin-induced diabetes. Materials and Methods: DNA damage was evaluated in the kidney cells of rats using alkaline comet assays. Oxidative stress parameters such as CAT, SOD, GR, and GSH-Px enzyme activities and total GSH and MDA levels were also evaluated. Results: Ursolic acid treatment was found to significantly decrease DNA damage, GR enzyme activities, and MDA levels, and significantly increase GSH levels and CAT, SOD and GSH-Px enzyme activities in diabetic rats. Conclusion: According to our results, it seems that ursolic acid may be beneficial against diabetes-induced renal damage.

show abstract

Pharmacognosy: phytomedicines and their mechanisms

Cited by 34 publications

References 90 publications

Pharmacological evaluation of the aqueous stem bark extract of Bombax buonopozense in the relief of pain and fever

Pharmacological evaluation of the aqueous stem bark extract of Bombax buonopozense in the relief of pain and fever

<i>Drymaria cordata</i> (Linn.) Willd (Caryophyllaceae): Ethnobotany, Pharmacology and Phytochemistry

Protective Effects of Ursolic Acid in the Kidneys of Diabetic Rats

Contact Info

Product

Resources

About

Pharmacognosy: phytomedicines and their mechanisms

Cited by 34 publications

References 90 publications

Pharmacological evaluation of the aqueous stem bark extract of Bombax buonopozense in the relief of pain and fever

Pharmacological evaluation of the aqueous stem bark extract of Bombax buonopozense in the relief of pain and fever

&lt;i&gt;Drymaria cordata&lt;/i&gt; (Linn.) Willd (Caryophyllaceae): Ethnobotany, Pharmacology and Phytochemistry

Protective Effects of Ursolic Acid in the Kidneys of Diabetic Rats

Contact Info

Product

Resources

About

<i>Drymaria cordata</i> (Linn.) Willd (Caryophyllaceae): Ethnobotany, Pharmacology and Phytochemistry