Pharmacokinetic behaviour of enrofloxacin in greater rheas following a single-dose intramuscular administration

Preparation, characterization and pharmacokinetics of enrofloxacin-loaded solid lipid nanoparticles: Influences of fatty acids

“…Native drug resulted in a detectable level in plasma for 12 h, which was longer than that after intravenous injection [29] and similar to that by subcutaneous injection [30]. The T ½el , T max and AUC 0-∞ were similar to those obtained in greater rheas by intramuscular administration [31]. This SLN profile is desirable for sustained-release products where the initial release rate should be sufficiently rapid to ensure that the therapeutic drug levels are achieved in a timely manner.…”

Activity of superoxide dysmutase, catalase and glutathione peroxidase in rats exposed to chlorpyrifos and erofloxacin

“…: Gram-positive and Gram-negative bacteria, mycoplasmas and chlamydia (Boothe et al 2006, Elmas et al 2006, Grobbel et al 2007). Owing to its lipophilic properties, enrofloxacin is rapidly absorbed from the alimentary tract, quickly reaches therapeutic concentration (De Lucas et al 2008, Bimazubute et al 2010) and easily penetrates into the tissues and cells (Anadon et al 1999, Wiuff et al 2002. In the body of different species of animals enrofloxacin is subjected to metabolic transformation into ciprofloxacin, which chemotherapeutic activity is comparable to the maternal substance (Riddle et al 2000, Grobbel et al 2007).…”

Pharmacokinetics and tissue distribution of enrofloxacin after single intramuscular injection in Pacific white shrimp

“…administration, and the value was longer than 3.0 and 2.85 hr in Angora rabbits and greater rheas after i.m. administration, respectively (De Lucas et al, 2008;Elmas et al, 2007); in contrast, it was lower than 28.9…”

“…administration, and the value was longer than 3.0 and 2.85 hr in Angora rabbits and greater rheas after i.m. administration, respectively (De Lucas et al., ; Elmas et al., ); in contrast, it was lower than 28.9 and 85 hr in red pacu and Atlantic salmon, respectively (Lewbart et al., ; Stoffregen et al., ). This apparent discrepancy may indicate interspecies differences.…”

“…It was reported EF reached mean peak plasma concentration in 25 and 24.7 min in Angora rabbits and greater rheas after i.m. administration, respectively (De Lucas et al., ; Elmas, Uney, Yazar, Karabacak, & Traş, ). In Atlantic salmon and red pacu plasma, T max for EF i.m.…”