Activity of superoxide dysmutase, catalase and glutathione peroxidase in rats exposed to chlorpyrifos and erofloxacin

Barski, D.; Spodniewska, A.; Zasadowski, A

doi:10.2478/v10181-011-0078-8

Cited by 10 publications

(6 citation statements)

References 35 publications

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“…Even though enrofloxacin is generally regarded as safe drug, the information on its oxidative properties is not unambiguous (Barski et al, 2011;Qin and Liu, 2013). However, the slight decrease in the levels of vitamins A and E, as observed in present studies, indicates that the administration of enrofloxacin, even at a therapeutic dose, may result in disturbances to antioxidative mechanisms, and confirms its capacity for the prooxidative action.…”

Section: Discussionsupporting

confidence: 60%

Effect of enrofloxacin and chlorpyrifos on the levels of vitamins A and E in Wistar rats

Spodniewska¹,

Barski²,

Giżejewska³

2015

Environmental Toxicology and Pharmacology

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Section: Discussionsupporting

confidence: 60%

Effect of enrofloxacin and chlorpyrifos on the levels of vitamins A and E in Wistar rats

Spodniewska¹,

Barski²,

Giżejewska³

2015

Environmental Toxicology and Pharmacology

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“…Nevertheless, we cannot conclusively say that similar oxidative stress is caused also in toads. In this sense, four-week exposure of rats to CPF caused noticeable decrease in CAT activity in erythrocytes (Barski et al ., 2011).…”

Section: Discussionmentioning

confidence: 99%

Blood biomarkers of common toad Rhinella arenarum following chlorpyrifos dermal exposure

Peltzer

Attademo

Colussi³

et al. 2018

Interdisciplinary Toxicology

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Chlorpyrifos (CPF) is a broad spectrum pesticide commonly used for insect control, has great affinity for lipids and is thus a potential for bioaccumulation in aquatic organisms. The aim of this study was to evaluate the toxicity of CPF using the common toad Rhinella arenarum via dermal uptake in plastic bucket to simulate their natural exposition in ponds. R. arenarum toads were exposed individually to solutions containing a nominal concentration of a commercial formulation of CPF insecticide (5 and 10 mg/L). Different enzyme biomarkers (BChE: butyrylcholinesterase, CbE: carboxylesterase, and CAT: catalase) were measured in blood tissue after exposition. The capacity of pyridine-2-aldoxime methochloride (2-PAM) to reverse OP-inhibited plasma BChE and the ratio of heterophils and lymphocytes (H/L) as hematological indicators of stress were also determined. The normal values of plasma B-sterases (BChE and CbE) were highly inhibited (until ≈ 70%) in toads 48 h after exposure to CPF. The results indicate that 2-PAM produced BChE reactivation as well. The activity of CAT was also inducted for dermal exposure at more than double of that in the control toads (CPF; 5 mg/L). H/L ratios did not reveal a significantly increased stress. The study suggests that CPF via dermal uptake induced neurotoxicity and oxidative stress in the common toad R. areanum. Thus, some blood biomarkers employed in our study (i.e. BChE, CbE, 2-PAM, and CAT) might be used as predictors in health and ecological risk assessment of amphibian populations exposed to CPF.

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“…Various experimental studies involving CPF administration have shown inhibition of SOD activity in rat liver (Mansour and Mossa, 2010;Khalifa et al, 2011). CPF also decreased SOD activity compared with the control group in rat erythrocytes (Demir et al, 2011;Barski et al, 2011;Saxena et al, 2011).…”

Section: Scanning Electron Microscopic Observations Of Red Blood Cellsmentioning

confidence: 99%

The Role of Tinospora cordifolia in Extenuating the Toxic Effects of CPF on Hepatic Modifications along with Electron Microscope observations in Red Blood Cells

Aggarwal¹,

Singh²

2016

Int.J.Curr.Microbiol.App.Sci

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This study investigates the role of Tinospora cordifolia (TC) extract against liver damage induced in male albino rat by an Organophosphorus (OP) insecticide, Chloropyrifos (CPF). Liver damage was investigated by various parameters like Lipid peroxidation (LPO), Superoxide dismutase (SOD), Catalase, Glutathione reductase (GR), Lactate dehydrogenase (LDH), Acid phosphatase, Na + /K + -ATPase and Acetyl cholinesterase (AChE) and Scanning Electron microscope (SEM) observation on blood cells. Group I Control group, Group II 30 mg/kg CPF b. wt., Group III TC 1.0 g/kg b. wt. with 30 mg/kg CPF b. wt., Group IV TC 2.0 g/kg b.wt. with 30 mg/kg CPF b. wt., Group V TC 4.0 g/kg b.wt. with 30 mg/kg CPF b. wt. and Group VI 4.0 g/kg b.wt. of TC were administered orally via gavages. The results showed that TC overcome the CPF induced decreased levels of SOD, Catalase, Glutathione reductase, LDH, Acid Phosphatase, Na + /K + -ATPase and AChE compare to CPF control. Moreover, TC significantly decreased the LPO level induced by CPF as compared to CPF control. The drastic alterations in the shape of the blood cells were reverted significantly with the increasing doses concentration of TC. Therefore, it could be concluded that TC administration is useful in routine therapy for protection against tissue damage induced by CPF.

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Activity of superoxide dysmutase, catalase and glutathione peroxidase in rats exposed to chlorpyrifos and erofloxacin

Cited by 10 publications

References 35 publications

Effect of enrofloxacin and chlorpyrifos on the levels of vitamins A and E in Wistar rats

Effect of enrofloxacin and chlorpyrifos on the levels of vitamins A and E in Wistar rats

Blood biomarkers of common toad Rhinella arenarum following chlorpyrifos dermal exposure

The Role of Tinospora cordifolia in Extenuating the Toxic Effects of CPF on Hepatic Modifications along with Electron Microscope observations in Red Blood Cells

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