Pharmacokinetic comparison of an oral diclofenac potassium liquid-filled soft gelatin capsule with a diclofenac potassium tablet

Lissy, Michael; Scallion, Ralph; Stiff, Dwight D.; Moore, Keith A.

doi:10.1517/14656561003614773

Cited by 17 publications

(19 citation statements)

References 18 publications

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“…Among all, diclofenac potassium liquid-filled soft gel capsules were demonstrated to be more rapidly and consistently absorbed than the commercially available diclofenac potassium tablets, resulting in a shorter and more consistent time to onset of analgesia [35]. Similarly, ibuprofen in soft gel is absorbed faster than both film-coated tablet and liquid (prepared from effervescent ibuprofen tablet) [36].…”

Section: Discussionmentioning

confidence: 99%

Soft gel capsules improve melatonin’s bioavailability in humans

Proietti

Carlomagno²,

Dinicola

et al. 2014

Expert Opinion on Drug Metabolism & Toxicology

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Section: Discussionmentioning

confidence: 99%

Soft gel capsules improve melatonin’s bioavailability in humans

Proietti

Carlomagno²,

Dinicola

et al. 2014

Expert Opinion on Drug Metabolism & Toxicology

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“…The solution-softgel formulation provided around three times the bioavailability of saquinavir as measured by the area under the plasma-time curve (AUC), compared to a hard-shell capsule formulation [25]. The bioavailability of digoxin was reported to have increased significantly when formulated and administered as a liquid in a soft capsule and that dose adjustment were necessary when patients were switched from tablets to liquid-filled capsules [26].…”

Section: Increased Bioavailability Of Drugsmentioning

confidence: 99%

“…By preparing a solution or suspension of drug, where the active component is essentially protected from the environment by the liquid, such safety concerns and associated toxicities have been significantly reduced [29].…”

Section: Safety For Potent and Cytotoxic Drugmentioning

confidence: 99%

Formulation and modifying drug release from Hard and Soft Gelatin Capsules for Oral drug delivery

Prasad

2017

IJRDPL

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Available online on:15.06.2017@http://ijrdpl.com http://dx.doi.org/10.21276/IJRDPL.227 8-0238.2017.6(4). [2663][2664][2665][2666][2667][2668][2669][2670][2671][2672][2673][2674][2675][2676][2677] ABSTRACT: Capsule is the most versatile of all dosage forms. Capsules are solid dosage forms in which one or more medicinal and inert ingredients are enclosed in a small shell or container usually made of gelatin. There are two types of capsules, "hard" and "soft". The hard capsule is also called "two pieces" as it consists of two pieces in the form of small cylinders closed at one end, the shorter piece is called the "cap" which fits over the open end of the longer piece, called the "body". The soft gelatin capsule is also called as "one piece". Capsules are available in many sizes to provide dosing flexibility. Unpleasant drug tastes and odors can be masked by the tasteless gelatin shell. The administration of liquid and solid drugs enclosed in hard gelatin capsules is one of the most frequently utilized dosage. This proves the oral bioavailability of poorly soluble compounds, delivery of low and ultra-low doses of a compound using softgel also ensures decreased plasma variability. This has led to the commercial pharmaceutical and nutraceutical industries opting for the development of alternative shell forming materials instead of the traditional capsule shell material gelatin. This review discusses establishment and the ongoing development of the manufacturing technology for liquid and semisolid capsules with focus on progress and challenges of soft and hard gelatin capsules formulation in oral administration for improved solubility and as an absorption-enhancing technique. These considerations form a basis for new applications in oral drug delivery.⇑ Corresponding author at: (4).2663-2677ABSTRACT: Capsule is the most versatile of all dosage forms. Capsules are solid dosage forms in which one or more medicinal and inert ingredients are enclosed in a small shell or container usually made of gelatin. There are two types of capsules, "hard" and "soft". The hard capsule is also called "two pieces" as it consists of two pieces in the form of small cylinders closed at one end, the shorter piece is called the "cap" which fits over the open end of the longer piece, called the "body". The soft gelatin capsule is also called as "one piece". Capsules are available in many sizes to provide dosing flexibility. Unpleasant drug tastes and odors can be masked by the tasteless gelatin shell. The administration of liquid and solid drugs enclosed in hard gelatin capsules is one of the most frequently utilized dosage. This proves the oral bioavailability of poorly soluble compounds, delivery of low and ultra-low doses of a compound using softgel also ensures decreased plasma variability. This has led to the commercial pharmaceutical and nutraceutical industries opting for the development of alternative shell forming materials instead of the traditional capsule shell material gelatin. This review discusses establishment and the ongoing ...

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“…Intranasal drug administration may provide a simple, noninvasive therapy that could allow for rapid pain relief following opioid [94,95] or NSAID administration with limited systemic exposure [113]. Diclofenac gel capsules with enhanced absorption properties compared with diclofenac potassium immediate-release tablets [114,115], and capsules developed using finer-milled particles that result in rapid drug absorption [116] may provide more rapidly acting, lower-dose alternatives to traditional NSAID formulations. However, the new dosage forms may not be affordable for patients; their utility in the ED setting will depend in part on pricing and insurance coverage.…”

Section: New Therapeutic Options For the Management Of Acute Painmentioning

confidence: 99%

Improving acute pain management in emergency medicine

Pollack

Viscusi

2015

Hospital Practice

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Undertreatment of pain (oligoanalgesia) in the emergency department is common, and it negatively impacts patient care. Both failure of appropriate pain assessment and the potential for unsafe analgesic use contribute to the problem. As a result, achieving satisfactory analgesia while minimizing side effects remains particularly challenging for emergency physicians, both in the emergency department and after a patient is discharged. Improvements in rapid pain assessment and in evaluation of noncommunicative populations may result in a better estimation of which patients require analgesia and how much pain is present. New formulations of available treatments, such as rapidly absorbed, topical, or intranasal nonsteroidal anti-inflammatory drug formulations or intranasal opioids, may provide effective analgesia with an improved risk-benefit profile. Other pharmacological therapies have been shown to be effective for certain pain modalities, such as the use of antidepressants for musculoskeletal pain, γ-aminobutyric acid agonists for neuropathic and postsurgical pain, antipsychotics for headache, and topical capsaicin for neuropathic pain. Nonpharmacological methods of pain control include the use of electrical stimulation, relaxation therapies, psychosocial/manipulative therapies, and acupuncture. Tailoring of available treatment options to specific pain modalities, as well as improvements in pain assessment, treatment options, and formulations, may improve pain control in the emergency department setting and beyond.

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Pharmacokinetic comparison of an oral diclofenac potassium liquid-filled soft gelatin capsule with a diclofenac potassium tablet

Cited by 17 publications

References 18 publications

Soft gel capsules improve melatonin’s bioavailability in humans

Soft gel capsules improve melatonin’s bioavailability in humans

Formulation and modifying drug release from Hard and Soft Gelatin Capsules for Oral drug delivery

Improving acute pain management in emergency medicine

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