Pharmacokinetic evaluation of differential drug release formulations of rabeprazole in dogs

Patel, Harilal; Desai, Nirmal D.; Patel, Prakash; Modi, Nirav; Soni, Krunal; Patel, Jitendrakumar Rameshchandra; Mistry, Gaurav N.; Patel, Jitendrakumar D; Chawla, Manish; Srinivas, Nuggehally R.

doi:10.1080/03639045.2019.1628249

Cited by 6 publications

(2 citation statements)

References 17 publications

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“…Gels consisting of one phase have a faster drug release than creams consisting of two phases. This is evidenced by the research of Patel et al (2009), where the release profile of psoralen gel preparations was greater than psoralen cream, namely 48.11 ± 2.1% and 25.96 ± 1.2. The release of active substances in gel preparations is also strongly influenced by gelling agents.…”

Section: Introductionmentioning

confidence: 88%

In Vitro Release Ability of Nanoparticles Poly-Lactic-Co-Glycolic-Acid (PLGA) Gel Containing Pegagan Leaves Ethanolic Extract (Centella asiatica L.)

Mardiyanto

Apriani

Jati

2023

JFIKI

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Background: Pegagan (Centella asiatica L.) leaves are proven to contain high concentrations of flavonoid compounds as antioxidants. Flavonoids are unstable compounds due to environmental influences such as light, humidity, pH, and oxygen. The stability of pegagan extract was proven to be improved by making the extract into nanoparticle preparations. Objective: This study aims to formulate nanoparticles of pegagan into gel preparations and determine their release ability with the Franz diffusion test using a cellophane membrane compared to pegagan gel not formulated into nanoparticles. Methods: Nanoparticles were made using poly-lactic-co-glycolic acid polymers and then formulated into gels with various concentrations of Carbopol 934, namely 1, 1.5 and 2%. The gel nanoparticles were then subjected to the characterization of the preparation, stability test and release test of the preparation. Results: A concentration of 1% Carbopol 934 provides the best evaluation of gel preparations where the gel produced was homogeneous, pH was around 6.2, viscosity was 3417.12 cPs, spreadability was 5.1 cm, and adhesion was 209.33 seconds. The stability test showed no significant organoleptic and pH changes (p>0.05). The release kinetics model occurs at zero order. F1 has a higher reaction kinetics constant (k) than the other formulations, so drug release occurs faster. Conclusion: The best formula of pegagan (F1) nanoparticle gel was proven to have good physical stability and release ability.

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Section: Introductionmentioning

confidence: 88%

In Vitro Release Ability of Nanoparticles Poly-Lactic-Co-Glycolic-Acid (PLGA) Gel Containing Pegagan Leaves Ethanolic Extract (Centella asiatica L.)

Mardiyanto

Apriani

Jati

2023

JFIKI

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“…Patel et al have developed psoralen-loaded cream and hydrogel formulations. They reported that the release of the drug from gel formulations was higher compared to the cream [62]. In another study, Sankar et al reported that their hydrocortisone gel formulation reached a level of release about 2 times higher than the hydrocortisone commercial cream [63].…”

Section: Drug Release Studiesmentioning

confidence: 99%

Development and evaluation of azelaic acid-cyclodextrin hydrogels for treatment of acne

Davut ARPA,

DOĞAN,

GÜNDÜZ

et al. 2024

jrp

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Acne is an inflammatory or non-inflammatory disease that can be seen at every stage of human life and affects daily life both physically and psychologically. In the topical treatment of acne, substances with different pharmacological effects such as benzoyl peroxide, isotretinoin, azelaic acid (AZE), and erythromycin are used alone or in combination. AZE cream (20%) has been frequently preferred in the treatment of mild and moderate acne in recent years. However, since AZE has poor solubility in water, its low permeability problems may occur. In this study, the soluble form of AZE was obtained by forming an inclusion complex of AZE with 2-hydroxypropyl β-cyclodextrin (HβC). In addition, the gel formulation, which generally exhibits higher permeability properties than oily formulations, was prepared using hydroxypropyl methylcellulose (HPMC). The formation of the inclusion complex was confirmed by NMR, XRD, DSC, and FTIR analyses. As a result of the characterization studies of the hydrogel formulations, it was determined that they had pseudoplastic flow and their viscosity was approximately 220 Pa.s. In drug release studies conducted with the dialysis bag method, it was found that the AZE-HβC hydrogel formulations had a similar cumulative release percent as HβC-free hydrogels but showed a higher cumulative release percent than the commercial cream (Azelderm, Orva, Türkiye). It was proven that the drug release of the formulations that exhibit a release profile in accordance with Higuchi kinetics was different from Azelderm according to difference (f1) and similarity (f2) factors.

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Formulation development and pharmacokinetic evaluation of enteric-coated dexrabeprazole tablets

Lee

Kim

et al. 2022

J. Pharm. Investig.

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Pharmacokinetic evaluation of differential drug release formulations of rabeprazole in dogs

Abstract: Supplemental Table S1: Individual animal pharmacokientic parameters of rabeprazole following 20 mg oral administration of rabeprazole sodium test drug product and reference product formulations in beagle dog.

Cited by 6 publications

References 17 publications

In Vitro Release Ability of Nanoparticles Poly-Lactic-Co-Glycolic-Acid (PLGA) Gel Containing Pegagan Leaves Ethanolic Extract (Centella asiatica L.)

In Vitro Release Ability of Nanoparticles Poly-Lactic-Co-Glycolic-Acid (PLGA) Gel Containing Pegagan Leaves Ethanolic Extract (Centella asiatica L.)

Development and evaluation of azelaic acid-cyclodextrin hydrogels for treatment of acne

Formulation development and pharmacokinetic evaluation of enteric-coated dexrabeprazole tablets

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