Pharmacokinetic profile of cefquinome after oral subchronic flubendiamide exposure and in vitro plasma protein binding in buffalo calves

Venkatachalam, Dinakaran; Dumka, V. K.

doi:10.1016/j.etap.2014.12.004

Cited by 6 publications

(3 citation statements)

References 33 publications

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“…Fortunately, some antimicrobials have good efficacy against bacteria isolated from water buffalo. 4,15,32 Ceftiofur, a third-generation broad-spectrum cephalosporin, has been widely recommended for the treatment of infectious diseases in pigs and cattle. 4,15,32 Ceftiofur, a third-generation broad-spectrum cephalosporin, has been widely recommended for the treatment of infectious diseases in pigs and cattle.…”

Section: Discussionmentioning

confidence: 99%

Comparative pharmacokinetics of ceftiofur hydrochloride and ceftiofur sodium after administration to water buffalo (Bubalus bubalis)

Nie¹,

Feng²,

Peng³

et al. 2016

ajvr

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OBJECTIVE To evaluate pharmacokinetics and bioavailability after administration of ceftiofur hydrochloride and ceftiofur sodium to water buffalo (Bubalus bubalis). ANIMALS 5 healthy adult water buffalo (3 males and 2 nonlactating females). PROCEDURES All animals received a dose (2.2 mg/kg) of 3 ceftiofur products (2 commercially available suspensions of ceftiofur hydrochloride [CEF1 and CEF2, IM] and ceftiofur sodium [CEF3, IV]). Blood samples were collected for up to 196 hours. Concentrations of ceftiofur in plasma were determined by use of high-performance liquid chromatography, and pharmacokinetic parameters were calculated on the basis of noncompartmental methods. RESULTS Most of the pharmacokinetic parameters, except for bioavailability and the area under the concentration-time curve extrapolated to infinity, were significantly different between the 2 products administered IM. Mean ± SD bioavailability of CEF1 and CEF2 was 89.57 ± 32.84% and 86.28 ± 11.49%, respectively, which indicated good absorption of both products. In addition, there was a longer drug residence time for CEF1 than for CEF2. Data analysis for CEF1 revealed a flip-flop phenomenon. CONCLUSIONS AND CLINICAL RELEVANCE In this study, there was good absorption of CEF1, and CEF1 had a longer drug residence time in vivo than did CEF2. On the basis of pharmacokinetic parameters and the in vitro antimicrobial susceptibility, a dosage regimen of 2.2 mg/kg administered at 48- and 36-hour intervals for CEF1 and CEF2, respectively, could be an appropriate choice for the treatment of buffalo with infectious diseases.

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Section: Discussionmentioning

confidence: 99%

Comparative pharmacokinetics of ceftiofur hydrochloride and ceftiofur sodium after administration to water buffalo (Bubalus bubalis)

Nie¹,

Feng²,

Peng³

et al. 2016

ajvr

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“…CFQ could potentially be used for the treatment of many turtle diseases. Pharmacokinetic studies of CFQ have been investigated in salmon (San Martín, Bataglia, Hernández, Quiroz, & Cañon, ), camels (Al‐Taher, ), rabbits (Hwang et al., ), sheep (Tohamy, ; Uney, Altan, & Elmas, ), ducks (Yuan et al., ), ponies (Smiet, Haritova, Heil, Fink‐Gremmels, & Wijnberg, ), cross‐bred wild boars (Liu et al., ), chickens (Xie, Zhang, Wang, & Du, ), pigs (Zhao et al., ), cattle (Shan et al., ), tilapia (Shan et al., ), dogs (Zhang et al., ), buffalo calves (Venkatachalam & Dumka, ), and horses (Uney et al., ). These studies have reported favorable pharmacokinetic features of CFQ, such as good absorption, high bioavailability, and primary elimination via the kidney.…”

Section: Pharmacokinetic Parameters Of Cfq In Red‐eared Sliders (N = mentioning

confidence: 99%

Pharmacokinetics of cefquinome in red‐eared slider turtles (Trachemys scripta elegans) after single intravenous and intramuscular injections

Üney

Altan

Gül

et al. 2017

Vet Pharm & Therapeutics

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The purpose of this study was to evaluate the pharmacokinetics of cefquinome (CFQ) following single intravenous (IV) or intramuscular (IM) injections of 2 mg/kg body weight in red-eared slider turtles. Plasma concentrations of CFQ were determined by high-performance liquid chromatography and analyzed using noncompartmental methods. The pharmacokinetic parameters following IV injection were as follows: , and total body clearance (Cl T ) 12.66 ± 2.51 ml hr −1 kg −1. The pharmacokinetic parameters after IM injection were as follows: peak plasma concentration (C max ) 3.94 ± 0.84 μg/ml, time to peak concentration (T max ) 3 hr, t 1/2λz26.90 ± 4.33 hr, and AUC 0-∞ 145 ± 48 μg hr −1 ml −1. The bioavailability after IM injection was 88%. Data suggest that CFQ has a favorable pharmacokinetic profile with a long half-life and a high bioavailability in red-eared slider turtles. Further studies are needed to establish a multiple dosage regimen and evaluate clinical efficacy.

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“…However, the elimination process of CFQ was observed to be delayed in neonatal sheep (Tohamy, 2011). The binding rate of CFQ to plasma proteins was found to be approximately 11% in buffalo calves (Venkatachalam & Dumka, 2015). Another study reported that the excretion extent of CFQ correlated with glomerular filtration rate in dogs; however, data in calves are not available (Taverne, van Geijlswijk, Heederik, Wagenaar, & Mouton, 2016).…”

Section: Discussionmentioning

confidence: 99%

Pharmacokinetics and bioavailability of cefquinome and ceftriaxone in premature calves

Çorum

Yıldız

İder

et al. 2019

Vet Pharm & Therapeutics

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The aim of this study was to evaluate the pharmacokinetics and bioavailability of cefquinome (CFQ) and ceftriaxone (CTX) following intravenous (IV) and intramuscular (IM) administrations in premature calves. Using a parallel design, 24 premature calves were randomly divided into the two antibiotic groups. Each of the six animals in the first group received CFQ (2 mg/kg) through IV or IM administration. The second group received CTX (20 mg/kg) via the same administration route. Plasma concentrations of the drugs were analyzed by high‐performance liquid chromatography and noncompartmental methods. Mean pharmacokinetic parameters of CFQ and CTX following IV administration were as follows: elimination half‐life (t1/2λz) 1.85 and 3.31 hr, area under the plasma concentration–time curve (AUC0–∞) 15.74 and 174 hr * μg/ml, volume of distribution at steady‐state 0.37 and 0.45 L/kg, and total body clearance 0.13 and 0.12 L hr−1 kg−1, respectively. Mean pharmacokinetic parameters of CFQ and CTX after IM injection were as follows: peak concentration 4.56 and 25.04 μg/ml, time to reach peak concentration 1 and 1.5 hr, t1/2λz 4.74 and 3.62 hr, and AUC0–∞ 22.75 and 147 hr * μg/ml, respectively. The bioavailability of CFQ and CTX after IM injection was 141% and 79%, respectively. IM administration of CFQ (2 mg/kg) and CTX (20 mg/kg) can be recommended at 12‐hr interval for treating infections caused by susceptible bacteria, with minimum inhibitory concentration values of ≤0.5 and ≤4 μg/ml, respectively, in premature calves. However, further research is indicated to assess the pharmacokinetic parameters following multiple doses of the drug in premature calves.

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Pharmacokinetic profile of cefquinome after oral subchronic flubendiamide exposure and in vitro plasma protein binding in buffalo calves

Cited by 6 publications

References 33 publications

Comparative pharmacokinetics of ceftiofur hydrochloride and ceftiofur sodium after administration to water buffalo (Bubalus bubalis)

Comparative pharmacokinetics of ceftiofur hydrochloride and ceftiofur sodium after administration to water buffalo (Bubalus bubalis)

Pharmacokinetics of cefquinome in red‐eared slider turtles (Trachemys scripta elegans) after single intravenous and intramuscular injections

Pharmacokinetics and bioavailability of cefquinome and ceftriaxone in premature calves

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