Pharmacokinetic scaling of pindolol in healthy volunteers after
single dose oral administration

Hj, Koch; Raschka, Christoph

doi:10.1358/mf.2002.24.2.677126

Cited by 2 publications

(2 citation statements)

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“…Koch et al proposed a yeast toxicity test as an alternative to using vertebrates in pharmaceutical screening. 31 Yeast IC 50 s were calculated from the influence of the test samples on growth rate and correlated to animal LD 50 s. Repeated counting of the number of cells was required, performed either manually using a microscope or in an automated fashion using a Coulter cell counter. Such equipment is expensive and immobile, restricting its use in an environmental setting.…”

Section: Pure Compounds -Cytotoxicitymentioning

confidence: 99%

A yeast-based cytotoxicity and genotoxicity assay for environmental monitoring using novel portable instrumentation

Knight

Keenan

Goddard

et al. 2004

J. Environ. Monitor.

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An assay capable of simultaneously measuring both general toxicity and more subtle genotoxicity, in aqueous environmental samples, is described. The assay uses eukaryotic (yeast) cells, genetically modified to express a green fluorescent protein (GFP) whenever DNA damage, as a result of exposure to genotoxic agents, is repaired. A measure of the reduction in cell proliferation is used to characterise general toxicity producing familiar EC(50) and LOEC data. The assay protocol has been developed for proposed use in the field and hence employs dedicated, portable instrumentation, the development of which is described. A range of environmentally relevant substances has been evaluated using the assay, including solutions of metal ions, solvents and pesticides. Preliminary data comparing the yeast assay's response to that of a standard Daphnia test in the analysis of the toxicity of 34 varied industrial waste effluents are also presented. The sensitivity to a wide range of substances and effluents suggests the assay should be useful for environmental toxicity monitoring.

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Section: Pure Compounds -Cytotoxicitymentioning

confidence: 99%

A yeast-based cytotoxicity and genotoxicity assay for environmental monitoring using novel portable instrumentation

Knight

Keenan

Goddard

et al. 2004

J. Environ. Monitor.

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“…Yeast is a suitable test organism to monitor the toxicity of substances in water with a high sensitivity comparable to standard test systems like Daphnia magna and Vibrio sheri. [27][28][29][30][31] 2. Experimental…”

Section: Introductionmentioning

confidence: 99%

Photocatalytic degradation and toxicity evaluation of diclofenac by nanotubular titanium dioxide–PES membrane in a static and continuous setup

et al. 2015

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Pharmacokinetic scaling of pindolol in healthy volunteers after single dose oral administration

Cited by 2 publications

References 0 publications

A yeast-based cytotoxicity and genotoxicity assay for environmental monitoring using novel portable instrumentation

A yeast-based cytotoxicity and genotoxicity assay for environmental monitoring using novel portable instrumentation

Photocatalytic degradation and toxicity evaluation of diclofenac by nanotubular titanium dioxide–PES membrane in a static and continuous setup

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