Pharmacokinetic study of clarithromycin in human breast milk by UPLC–MS/MS

Kul, Aykut; Ozdemir, Murat; Sağırlı, Olcay

doi:10.1016/j.jpba.2021.114438

Cited by 3 publications

(1 citation statement)

References 32 publications

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“…In contrast, other recent methods need a specific column (length, particle diameter, etc.) [39] or UPLC-MS/MS apparatus which is quite expensive and demands considerable skill and expertise to assure success [41]. Looking at the run time, the application of this procedure using SunFire C18 column (150 × 4.6 mm id, 5 μm) showed a short retention time of CLA (in the order of 5 min), which makes it very suitable for any fast quantitative test.…”

Section: Comparison Of Methodsmentioning

confidence: 99%

Development and validation of high‐performance liquid chromatography method for determination of clarithromycin in pharmaceutical tablets

Mahmoudi,

De Francia,

Paul

2023

J of Separation Science

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Clarithromycin is a very important macrolide antibiotic used to treat bacterial infections in human and veterinary medicine. This study reports the development and validation of cost‐effective, simple, precise, accurate, and robust high‐performance liquid chromatography (HPLC) for the determination of clarithromycin (CLA) in tablets. Reversed‐phase chromatography was conducted using a standard column at 55°C with ultraviolet detection at 215 nm. A mobile phase consisting of acetonitrile –2‐methyl‐2‐propanol –potassium phosphate buffer was used at a flow rate of 1.0 mL/min. The proposed method displayed good linearity, precision, accuracy, robustness, and specificity. The present HPLC was compared with capillary electrophoresis and bioassay methods and the results indicated that there was no significant difference between these methods. Moreover, the obtained results demonstrated the validity of the isocratic HPLC, which allows reliable quantitation of CLA in pharmaceutical samples. Thus, it can be used as a substitute alternative methodology for the routine quality control of this medicine, in situations where other methods are less accessible in the laboratory.

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Section: Comparison Of Methodsmentioning

confidence: 99%

Development and validation of high‐performance liquid chromatography method for determination of clarithromycin in pharmaceutical tablets

Mahmoudi,

De Francia,

Paul

2023

J of Separation Science

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A Voltammetric Sensor Based on a Chitosan, Graphitized Carbon Black, and Molecularly Imprinted Polyarylene Phthalide Composite for Clarithromycin Detection

Yarkaeva,

Nazyrov,

Dymova

et al. 2024

J Anal Chem

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Voltammetric sensor based on a composite of chitosan, graphitized carbon black and polyarylenephthalide with molecular imprints for the determination of clarithromycin

Yarkaeva,

Nazyrov,

Dymova

et al. 2024

Zhurnal Analiticheskoi Khimii

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For selective determination of the antibiotic clarithromycin, a voltammetric sensor based on a glass-carbon electrode modified with a composite of chitosan, Carboblack C graphitized carbon black and polyarylenephthalide containing diphenylene-thio- and diphenylene oxide fragments in the main chain of the polymer in the ratio of 1 : 2 with molecular imprints of clarithromycin obtained by phase inversion method was developed. The composition and morphology of the modifying coating were studied using IR spectroscopy and scanning electron microscopy. The electrochemical and analytical characteristics of the sensor were studied by electrochemical impedance spectroscopy, cyclic and differential-pulse voltammetry. Optimal conditions for analytical signal registration were selected. Using [Fe(CN) ]63−/4− as a probe, the linear range of determined concentrations was 1 × 10-7 -5 × 10-4 M with a detection limit of 5.3 × 10-8 M. It is shown that the use of a polymer with molecular imprints of clarithromycin increases the sensitivity of the sensor almost 10 times compared to the non-imprinted polymer. The proposed sensor was tested on samples of urine, blood plasma, as well as food products (meat, milk), the degree of extraction was 90-96, 80 and 92%, respectively, and the relative standard deviation did not exceed 10% in all cases.

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Pharmacokinetic study of clarithromycin in human breast milk by UPLC–MS/MS

Cited by 3 publications

References 32 publications

Development and validation of high‐performance liquid chromatography method for determination of clarithromycin in pharmaceutical tablets

Development and validation of high‐performance liquid chromatography method for determination of clarithromycin in pharmaceutical tablets

A Voltammetric Sensor Based on a Chitosan, Graphitized Carbon Black, and Molecularly Imprinted Polyarylene Phthalide Composite for Clarithromycin Detection

Voltammetric sensor based on a composite of chitosan, graphitized carbon black and polyarylenephthalide with molecular imprints for the determination of clarithromycin

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