Pharmacokinetic study of multiple active constituents from Kushen–Gancao Decoction after oral administration in rat by HPLC–MS/MS

Wang, Qinhui; Shi, Lei; Tang, Xiuling; Wang, Qingwei; Dang, Xueliang; Zhang, Yan

doi:10.1016/j.jchromb.2014.05.038

Cited by 15 publications

(8 citation statements)

References 21 publications

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“…In Zou's study, the pharmacokinetic properties of 18a-GA and 18b-GA in 19 volunteers were evaluated after oral administration of diammonium glycyrrhizinate capsules (150 mg diammonium glycyrrhizinate) (Zou et al, 2009). The C max , AUC and MRT of 18b-GA was about 49.37 ± 3.93 ng/mL, 769.16 ± 143.42 ngÁh/mL and 18.85 ± 1.22 h, respectively, while for 18a-GA, the C max , AUC and MRT was about 20.32 ± 5.07 ng/mL, 335.26 ± 83.46 ngÁh/mL and 16.02 ± 1.20 h. In addition, another pharmacokinetic study found that GZ exhibits bimodal phenomenon in plasma concentration-time profiles (Wang et al, 2014b), which is probably due to the effect of hepatoenteral circulation of GZ (Ichikawa et al, 1986). In fact, GZ is predominantly secreted from the liver into the bile, and this biliary excretion is approximately 80% of the administered dose (Ishida et al, 1993).…”

Section: Discussionmentioning

confidence: 93%

Potential drug interactions associated with glycyrrhizin and glycyrrhetinic acid

Feng

Ding

Qiu

2015

Drug Metabolism Reviews

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Glycyrrhizin (GZ), the main active component of licorice, is a widely used therapeutic in the clinic. Depending on the disease, the treatment may involve a long course of high dose GZ. Another component of licorice, glycyrrhetinic acid (GA), is the main active metabolite of GZ and is thought to be responsible for the majority of the pharmacological properties of GZ. Therefore, GZ and GA are both used for therapeutic purposes. In addition, GZ and GA are also widely used to sweeten and flavor foods. Due to this widespread, multifaceted use of these substances, potential drug interactions with GZ and GA have recently gained attention. Along these lines, this review covers the known effects of GZ and GA on drug-metabolizing enzymes and efflux transporters. We conclude that both GZ and GA may have an effect on the activity of CYPs. For example, GZ may induce CYP3A activity through activation of PXR. Also, GZ and GA may affect glucuronidation in rats and humans. Furthermore, 18β-GA is a potent inhibitor of P-gp, while GZ and GA are inhibitors of MRP1, MRP2 and BCRP. The pharmacokinetics and pharmacodynamics of many medications may be altered when used concurrently with GZ or GA, which is also covered in this review. Overall, GZ, GA or related products should be taken with caution when taken with additional medications due to the possible drug interactions.

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Section: Discussionmentioning

confidence: 93%

Potential drug interactions associated with glycyrrhizin and glycyrrhetinic acid

Feng

Ding

Qiu

2015

Drug Metabolism Reviews

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“…In a previous study, we had developed a rapid and sensitive LC-MS/MS method to simultaneously determine Matrine (MT), Oxymatrine (OMT), Glycyrrhizin (GL) and Glycyrrhetinic acid (GA) in rat plasma after oral administration of Kusheng-Gancao (Wang et al, 2014). In this study, the pharmacokinetic parameters and the pharmacokinetic differences of the four ingredients after the administration of single-herb extracts and Kushen-Gancao were obtained.…”

Section: Introductionmentioning

confidence: 99%

Investigating herb–herb interactions: The potential attenuated toxicity mechanism of the combined use of Glycyrrhizae radix et rhizoma (Gancao) and Sophorae flavescentis radix (Kushen)

Shi

Tang

Dang

et al. 2015

Journal of Ethnopharmacology

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“…Glycyrrhetinic acid (GA) is the metabolite of glycyrrhizinic acid (GL) in vivo [5]; the fingerprinting of GA had been obtained [6], and the structure of GA is shown in Figure 1(b). There have been many researches about GA, such as the metabolic processes caused by mesaconitine-treated rats that could be mitigated by prophylaxis with GA, which meant that pretreatment with GA might reduce the toxicity of mesaconitine in the metabolic level [7]; GA has also been proved to be a typical active component of Shaoyao-Gancao Decoction for pain relief and be the major active constituent of Kushen-Gancao Decoction after oral administration in rat by HPLC-MS/MS [8, 9]. In another study about the comparative pharmacokinetic profiles of GA, GL, and Gancao-Fuzi-Tang after orally taking GL and Gancao-Fuzi-Tang, the results demonstrated an increased effect of GA after oral administration of Gancao-Fuzi-Tang in comparison with GL, which implied the GA was one of the crucial elements in Gancao-Fuzi-Tang [10].…”

Section: Introductionmentioning

confidence: 99%

Effects of Active Components of Fuzi and Gancao Compatibility on Bax, Bcl‐2, and Caspase‐3 in Chronic Heart Failure Rats

Wang

Zhang

Zhou

et al. 2016

Evidence-Based Complementary and Alternative Medicine

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Hypaconitine (HA) and glycyrrhetinic acid (GA) are active components of Fuzi (Aconitum carmichaelii) and Gancao (Glycyrrhiza uralensis Fisch); they have been used in compatibility for chronic heart failure (CHF) from ancient times. The purpose of the present research was to explore whether apoptosis pathways were related with the protective effects of HA + GA against CHF rats or not. The rats were progressed with transverse-aortic constriction (TAC) operation for 4 weeks to build the CHF state, and then the Digoxin (1 mg/kg), HA (2.07 mg/kg), GA (25 mg/kg), and HA (2.07 mg/kg) + GA (25 mg/kg) were orally administrated to rats for 1 week. The levels of BNP and cTnI in the plasma were decreased in the HA + GA group, and the heart/body weight ratio (H/B) and left ventricular (LV) parameters of transthoracic echocardiography were also declined; moreover, the expressions of Bax, Bcl-2, and caspase-3 were all improved in the HA + GA group than other groups in the immunohistochemistry and western blot methods. In general, the data suggested that Fuzi and Gancao compatibility could protect the CHF rats from apoptosis, which provided a strong evidence for further searching for mechanisms of them.

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Pharmacokinetic study of multiple active constituents from Kushen–Gancao Decoction after oral administration in rat by HPLC–MS/MS

Cited by 15 publications

References 21 publications

Potential drug interactions associated with glycyrrhizin and glycyrrhetinic acid

Potential drug interactions associated with glycyrrhizin and glycyrrhetinic acid

Investigating herb–herb interactions: The potential attenuated toxicity mechanism of the combined use of Glycyrrhizae radix et rhizoma (Gancao) and Sophorae flavescentis radix (Kushen)

Effects of Active Components of Fuzi and Gancao Compatibility on Bax, Bcl‐2, and Caspase‐3 in Chronic Heart Failure Rats

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