Pharmacokinetic study of oxytetracycline in fish. I. Absorption, distribution and accumulation in rainbow trout in freshwater

Rogstad, Astri; Hormazábal, Víctor; Ellingsen, Odd F.; Rasmussen, Knut

doi:10.1016/0044-8486(91)90151-v

Cited by 67 publications

(33 citation statements)

References 10 publications

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“…The tissue distributions of OTC in several fish species, such as salmonids, sea bream, and sea bass, following oral administration have been reported. The OTC level in the tissue of fish fed an OTC diet has been observed to accumulate in the order of stomach≫liver>kidney=skin> muscle at the conclusion of the OTC feeding period (Bruno 1989;Namdari et al 1996;Ozaki 1980;Rogstad et al 1991). Morphometric indices, such as the hepatosomatic index and the body condition factor, are often affected by dietary compounds and physiological condition (Ameur et al 2012;Ikeda et al 1986;Nakano et al 1995;Ozaki 1971).…”

Section: Discussionmentioning

confidence: 93%

“…The features of and the resulting effects of stressors on fish fitness should be understood to improve the health and growth of fish. Many studies concerning pharmacokinetics and residue elimination of OTC have been reported in various cultured fish species, such as rainbow trout, salmon, carp, sea bream, sea bass, yellowtail, and eel (Bruno 1989;Elia et al 2014;Malvisi et al 1996;Namdari et al 1996;Rogstad et al 1991;Ueno et al 2004;Uno et al 1992;Zhang and Li 2007). However, little is known about the effects of excessive doses of OTC as a chemical stressor for cultured fish on the expression of stress-related biomarkers, such as stress proteins, and on the redox state (Ameur et al 2012;Basu et al 2002;Elia et al 2014;Iwama et al 2006;Nakano et al 2014;Regoli and Giuliani 2014;Srikanth et al 2013;Yonar 2012;Yonar et al 2011).…”

Section: Introductionmentioning

confidence: 95%

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Effect of excessive doses of oxytetracycline on stress-related biomarker expression in coho salmon

Nakano

Hayashi

Nagamine

2015

Environ Sci Pollut Res

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Fish are exposed to a wide variety of environmental stressors, such as chemicals and acute changes in temperature. Oxytetracycline (OTC) has been used as an antibiotic for many kinds of bacterial diseases in cultured fish, but excessive doses of OTC are known to cause side effects in fish and can have negative effects on their environment. In the present study, we examined stress-related biomarker expression in response to excessive doses of dietary OTC in coho salmon (Oncorhynchus kisutch). Fish received OTC (100 mg/kg body weight/day) orally for 2 weeks. The percentage of liver to body weight (hepatosomatic index; HSI) and plasma biochemical parameter, alanine aminotransferase (ALT) activity, of the group fed a diet containing OTC were observed to be significantly higher than those of the control group. The total glutathione (tGSH) levels in the liver of OTC-fed fish were four fold higher than those in control fish and double the control levels in muscle and stomach. Plasma tGSH levels in OTC-fed fish were also higher than those in control fish. Expression levels of heat shock protein 70 in the liver, muscle, and stomach decreased by OTC administration. Accordingly, OTC-induced stress might increase the metabolic turnover of GSH due to consumption by scavenging oxidants generated by stress. These results concerning the changing patterns of stress-related biomarkers indicate that excessive doses of OTC fed to coho salmon induce oxidative stress, which might enhance oxidation in the body and result in damage to tissues, especially in the liver. The present results also suggest that tissue-specific damage caused by OTC might already exist in fish.

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Section: Discussionmentioning

confidence: 93%

Section: Introductionmentioning

confidence: 95%

Effect of excessive doses of oxytetracycline on stress-related biomarker expression in coho salmon

Nakano

Hayashi

Nagamine

2015

Environ Sci Pollut Res

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“…Rogstad et al (1991) found MIC values of 7.1 pg ml-' in skin and 19.1 pg ml-l in mucus. For oxolinic acid Rogstad et al (1993) found maximum serum and muscle values of 0.99 and 5.5 pg ml-', respectively.…”

Section: Discussionmentioning

confidence: 99%

Characterization of isolates of Flavobacterium psychrophilum associated with coldwater disease or rainbow trout fry syndrome:phenotypic and genomic studies

Lorenzen¹,

Dalsgaard²,

Bernardet³

1997

Dis. Aquat. Org.

107

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Isolates of Flavobacterium psychrophiluln (formerly Cytophaga psychrophila and Flexlbacter psychrophilus) mainly originating from clinical outbreaks of either coldwater disease (CWD) or rainbow trout fry syndrome (RTFS) were studied for selected biochemical, physiological, rnorphological and genomic characteristics, and compared with previously characterized French and American strains. DNA hybridization studies showed that the Danish isolates were highly related to the type strain, F. psychrophilum NCIMB 1 9 4 7~ Plasmid profiling of Danish isolates and those from other European countries revealed differences, which might be related to differences in pathogenicity. European ~solates originating from clinical outbreaks of either RTFS or CWD usually harboured one plasmid of 3.2 kb, whereas isolates originating from fish with different or no disease slgns had other profiles. Phenotypically, the Danish isolates appeared very homogeneous and shared most characteristics with the type strain, and with French and American strains studied by other authors. Further studies on the importance of the plasmids and the proteolytic activities of the bacterium might help in elucidating possible virulence factors.

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“…This observation could only be compatible with the 4:1 ratio if plasma concentrations z 4 mg/l could be regularly achieved. Even in the nine reports where oral intubation has been the method of administration (Strasdine and McBride, 1979;Nouws et al, 1992;Elema et al, 1996;Rogstad et al, 1991;Uno et al, 1992;Bylund, 1990, 1991), concentrations >3.5 mg/l have only been reported on one occasion (Bjørklund and Bylund, 1990). Thus, the breakpoints of Tsoumas et al (1989) are incompatible with the application of the 4:1 ratio to the published data on the plasma concentrations of OTC that can be achieved by any form of oral administration.…”

Section: Published Mic and C Max Valuesmentioning

confidence: 40%

On the validity of setting breakpoint minimum inhibition concentrations at one quarter of the plasma concentration achieved following oral administration of oxytetracycline

et al. 2004

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Pharmacokinetic study of oxytetracycline in fish. I. Absorption, distribution and accumulation in rainbow trout in freshwater

Cited by 67 publications

References 10 publications

Effect of excessive doses of oxytetracycline on stress-related biomarker expression in coho salmon

Effect of excessive doses of oxytetracycline on stress-related biomarker expression in coho salmon

Characterization of isolates of Flavobacterium psychrophilum associated with coldwater disease or rainbow trout fry syndrome:phenotypic and genomic studies

On the validity of setting breakpoint minimum inhibition concentrations at one quarter of the plasma concentration achieved following oral administration of oxytetracycline

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