Radiolabeled CRIP allows for noninvasive visualization of interstitial alterations during cardiac remodeling, and is responsive to antiangiotensin treatment. If proven clinically feasible, such a strategy would help identify post-MI patients likely to develop heart failure.

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Purpose:To investigate the feasibility of local delivery of a magnetic resonance (MR) contrast agent in vivo using paramagnetic thermosensitive liposomes and infrared (IR) laser-induced local hyperthermia under real-time MR thermometry on rabbit kidney. Materials and Methods:Respiratory gated, radio frequency (RF)-spoiled gradient-echo sequences were used for precise MR temperature mapping (SD ϭ 1°C). In vivo heating experiments confirmed local release of MR contrast agent from liposomes.Results: T 1 decreased from 800 msec to about 500 msec, as measured after tissue cooling, in those locations where the renal parenchyma was heated above the phase transition temperature of the liposome membrane. Conclusion:The release of MR contrast agent has been demonstrated in rabbit kidney in vivo. This may be used as a reporter for simultaneous release of therapeutic agents.

ByL.-B. C r o o n , Astn'Rogstad, T L e t h andT.Kiutamo *Four quick-test methods (the Foodoil sensor, RAU-Test,Fritest' and Spot test) and two ordinary laboratory methods (the free fatty acids and GLC determination of triglycerid h e r s ) were compared to a standard method (column chromatographic determination of polar compounds). One hundred samples collected from fast food shop and restaurants were included in the investigation. The Foodoil sensor showed the highest correlation to the standardmethod(c.f.= 094).TheRAU-Test,Fritest'andSpottestwerealso wellcorrelated to thestandardmethod.1t waseasiertocompare thecolourof the reaction mixtures to the colour scale of the RAU-Test than to that of the Fritest'.The amount offreefattyacids were found tobeanunreliableindicatorofdeteriorated fryingfat.The triglyceridedimers couldnotbequantified, but assessment by visual comparison of the peak pattern in the chromatc gram corresponded well with the results of the standard method.