Pharmacokinetics and bioavailability of cefquinome in healthy ducks

Abstract

Results indicated that cefquinome was absorbed quickly and had excellent bioavailability after IM administration, but absorption after PO administration was poor.

Integration of PK/PD for dose optimization of Cefquinome against Staphylococcus aureus causing septicemia in cattle

“…The reported terminal half life, clearance and Vss were respectively 2.4 ± 0.21 h, 0.11 ± 0.03 L/h.kg, 0.3 ± 0.5 L/kg and were very close to our values. The terminal elimination half-life of cefquinome is similar to values that were observed in piglet (Zhang et al, 2014), ducks (Liguo et al, 2011), rabbit (Hwang et al, 2011), and horses (Winther et al, 2011) in the range of (0.9–2.77 h) following IV administration. The volume of distribution at steady state was low which means that cefquinome was not as widely distributed as previously reported for piglet (Zhang et al, 2014), sheep (Uney et al, 2011), rabbits (Hwang et al, 2011), and horses (Winther et al, 2011) in the range (0.19–0.36 L/kg).…”

“…The advantages of cefquinome include broad spectrum antibacterial activity, stability against β-lactamase, enhanced potency, and bioavailability and the ability to penetrate easily into gram negative bacteria (Dumka et al, 2013). Cefquinome pharmacokinetics (PK) have been studied in several animal species such as camels, horses, ducks, cows, wild boars, piglet, rabbits and cattle (Allan and Thomas, 2003; Ehinger et al, 2006; Li et al, 2008; Al-Taher, 2010; Hwang et al, 2011; Liguo et al, 2011; Liu et al, 2012; Shan et al, 2014). …”

Influence of the Injection Site on the Pharmacokinetics of Cefquinome Following Intramuscular Injection in Piglets

“…Cefquinome was rapidly and almost completely absorbed (F, 103.04 ± 13.01% vs. 97.56 ± 16.14%, P>0.05) following i.m. injection into two different injection sites, which is consistent with the results in ducks, rabbits, wild boars and sheep [10,14,18,21]. In addition, this result was similar to that in a previous report in piglets after a single i.m.…”

“…This was similar to the findings for other species, the t 1/2λz and Cl of cefquinome ranged from 0.78 to 1.64 hr and 0.18 to 0.34 l/kg/hr in sheep, rabbits, wild boars and duck indicating the rapid elimination of cefquinome after i.v. injection [10,13,14,18,21]. The V ss of cefquinome in this study was 0.25 ± 0.04 l/kg, which was similar to the reported values of 0.23 l/kg in calves, 0.21 l/kg in rabbits and 0.21 l/kg in horses [10,13,19].…”

“…It has been approved for the treatment of respiratory diseases in pigs, respiratory tract diseases, acute mastitis and foot rot in cattle, calf septicemia and metritismastitis-agalactia syndrome in sows [3,4]. The pharmacokinetics of cefquinome have been reported in mice, horses, cattles, rabbits and ducks [6,10,13,20,21]. Cefquinome has several favorable pharmacokinetic features, such as good absorption, high bioavailability and direct elimination via the kidney.…”