1994
DOI: 10.1111/j.1365-2125.1994.tb04377.x
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Pharmacokinetics and biochemical efficacy of idrapril calcium, a novel ACE inhibitor, after multiple oral administration in humans.

Abstract: 1 The pharmacokinetic profile and biochemical efficacy of idrapril calcium, a novel angiotensin converting enzyme (ACE) inhibitor, were evaluated in healthy volunteers after multiple dosing for 5 days at the doses of 100, 200 and 400 mg twice daily. The study was conducted as a double-blind, cross-over comparison of idrapril calcium against placebo. 2 Plasma concentrations of idrapril were determined by an indirect enzymatic method. Urinary concentrations were measured by reverse phase high performance liquid … Show more

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Cited by 6 publications
(7 citation statements)
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“…Moreover, the ACE mRNA level was lower in cells treated with quercetin. Captopril and imidapril (synthetic ACEIs) inactivate the ACE molecule by binding a zinc atom at the active site and slowing the conversion of Ang I to Ang II [24,25]. Quercetin is known to bind metal ions including zinc [26], and there is evidence that quercetin may inhibit ACE activity via this mechanism [27].…”
mentioning
confidence: 98%
“…Moreover, the ACE mRNA level was lower in cells treated with quercetin. Captopril and imidapril (synthetic ACEIs) inactivate the ACE molecule by binding a zinc atom at the active site and slowing the conversion of Ang I to Ang II [24,25]. Quercetin is known to bind metal ions including zinc [26], and there is evidence that quercetin may inhibit ACE activity via this mechanism [27].…”
mentioning
confidence: 98%
“…Less than 10% of the oral dose of idrapril was found unchanged in urine (17). Limited data on idrapril kinetics are available in six hypertensive patients given a single oral dose of 200 mg (6).…”
Section: Pharmacokinetics and Metabolismmentioning
confidence: 98%
“…When given twice daily for five days to healthy volunteers at 100, 200, or 400 mg idrapril did not accumulate in plasma and no change in pharmacokinetic parameters was observed when the first and the last drug dose were compared (17). Less than 10% of the oral dose of idrapril was found unchanged in urine (17). Limited data on idrapril kinetics are available in six hypertensive patients given a single oral dose of 200 mg (6).…”
Section: Pharmacokinetics and Metabolismmentioning
confidence: 99%
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