Pharmacokinetics and metabolism of 2-[18F]fluoro-2-deoxy-d-glucose (FDG) in mammary tumors of antiestrogen-treated rats

Haaparanta, Merja; Paul, Robert; Huovinen, Riikka; Kujari, Harry; Bergman, Jörgen; Solin, Olof; Kangas, Lauri

doi:10.1016/0969-8051(94)00121-y

Cited by 11 publications

(9 citation statements)

References 7 publications

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“…For high‐performance liquid chromatography (HPLC)‐analysis, the tissue samples (liver, mesenteric white fat, skeletal muscle and hypothalamus) were homogenized and treated as described previously [21]. The metabolites of FDG were analysed by HPLC on a Radial‐PAK Partisil SAX column using 0.1 m acetate buffer and 0.1 m NaCl, pH 4.2, as the mobile phase at a flow rate of 2 ml/min.…”

Section: Methodsmentioning

confidence: 99%

2‐[¹⁸F]fluoro‐2‐deoxy‐d‐glucose combined with microdialysis can be used for the comparison of tissue glucose metabolism in obese and lean rats

Virtanen

Haaparanta

Grönroos

et al. 2002

Diabetes Obesity Metabolism

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Section: Methodsmentioning

confidence: 99%

2‐[¹⁸F]fluoro‐2‐deoxy‐d‐glucose combined with microdialysis can be used for the comparison of tissue glucose metabolism in obese and lean rats

Virtanen

Haaparanta

Grönroos

et al. 2002

Diabetes Obesity Metabolism

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“…The imaging plates were scanned using an FLA-7000 scanner (Fujifilm) and analyzed using the software MultiGauge (version 3.0, Fujifilm). The uptake of radioactivity into each brain region was expressed as a distribution absorption ratio (DAR), an index of radioligand accumulation corrected for body weight [28]. The DAR values were calculated using the following equation: DAR = (radioactivity of tissue/g of tissue) × (body weight/total injected dose).…”

Section: Net Autoradiographymentioning

confidence: 99%

The co-occurrence of zinc deficiency and social isolation has the opposite effects on mood compared with either condition alone due to changes in the central norepinephrine system

Mitsuya

Omata

Kiyono

et al. 2015

Behavioural Brain Research

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Nutritional and social environmental problems during the early stages of life are closely associated with the pathophysiology of mood disorders such as depression. Disruption or dysfunction of the central norepinephrine (NE) system is also considered to play a role in mood disorders. Therefore, we evaluated the effects of zinc deficiency and/or social isolation on mood and changes in the central NE system using rats. Compared with the controls, the rats subjected to zinc deficiency or social isolation alone exhibited increased anxiety-related behavior in the elevated plus maze and greater depression-like behavior in the forced swim test. However, the co-occurrence of zinc deficiency and social isolation resulted in decreased anxiety-related behavior and control levels of depression-like behavior. Social isolation alone decreased the rats' cerebral NE concentrations. The expression of the NE transporter was not affected by social isolation alone, but its expression in the locus coeruleus was markedly decreased by the co-occurrence of social isolation and zinc deficiency, and this change was accompanied by an increase in the blood concentration of 3-methoxy-4-hydroxyphenylglycol, which is a marker of central NE system activity. These findings suggest that zinc deficiency or social isolation alone induce anxious or depressive symptoms, but the presence of both conditions has anxiolytic or antidepressive effects. Furthermore, these opposing effects of mood-related behaviors were found to be associated with changes in the central NE system.

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“…Densitometric analyses of the autoradiograms were performed with a videodensitometry system (Excel TVIP-4100, Nippon Avionics, Japan). The results in respect of the uptake of radioactivity into various myocardial regions were expressed as distribution absorption ratios (DAR), an index of radioligand accumulation corrected by body weight [25]. DAR values were derived using the following equation: DAR = (radioactivity of tissue/g of tissue) × (body weight/total injected dose).…”

Section: Animalsmentioning

confidence: 99%

Norepinephrine transporter density as a causative factor in alterations in MIBG myocardial uptake in NIDDM model rats

et al. 2002

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Cardiac scintigraphic studies with iodine-123 labeled metaiodobenzylguanidine ([(123)I]MIBG) have demonstrated global and regionally pronounced decreases in myocardial accumulation of radioactivity in diabetes. The aim of this study was to investigate the cause of the regional differential decrease in accumulation. To this end, we investigated the global and regional myocardial distribution of [(125)I]MIBG in GK/Crj (GK) rats [a model of non-insulin-dependent diabetes mellitus (NIDDM)] and assessed the responsibility of regional myocardial blood flow, myocardial and plasma norepinephrine (NE) content, and norepinephrine transporter (NET) function for the regional variations in [(125)I]MIBG accumulation. To investigate the responsibility of myocardial blood flow for the alterations in MIBG accumulation, dual-isotope autoradiographic studies with [(125)I]MIBG and technetium-99m hexakis-2-methoxy-2-isobutylisonitrile (MIBI), a tracer for the measurement of myocardial blood flow, were carried out in GK rats and control rats. The results in respect of the uptake of radioactivity into various myocardial regions were expressed as distribution absorption ratios [DAR = (radioactivity of tissue/g of tissue) x (body weight/total injected dose)]. In control rats, uptake of [(125)I]MIBG was significantly higher in the inferior wall than in the anterior wall (anterior wall, 6.35 +/- 0.90; inferior wall, 8.12 +/- 1.27: P < 0.001). On the other hand, in GK rats, uptake of [(125)I]MIBG was similar between the anterior wall and the inferior wall (anterior wall, 4.91 +/- 0.71; inferior wall, 4.81 +/- 0.69). Compared with control rats, uptake of [(125)I]MIBG in GK rats was decreased in both the anterior wall and the inferior wall. Uptake of (99m)Tc-MIBI was not significantly different between the anterior and inferior walls in control (anterior wall, 17.9 +/- 4.42; inferior wall, 18.1 +/- 4.52) and GK rats (anterior wall, 16.6 +/-8.03; inferior wall, 16.7 +/- 7.90), indicating that myocardial blood flow did not change regionally in either control or GK rats, and that the blood flow was not responsible for the differential decrease in MIBG accumulation in GK rats. Cardiac and plasma NE levels were measured using an HPLC-electrochemical detection system. The cardiac and plasma NE concentrations were not significantly different between control (anterior wall, 347 +/- 56 ng/g; inferior wall, 354 +/- 31 ng/g; plasma 9.38 +/- 2.10 ng/ml) and GK rats (anterior wall, 323 +/- 62 ng/g; inferior wall, 344 +/- 35 ng/g; plasma, 9.41 +/- 2.39 ng/ml). The density and affinity of NET were investigated by studying the binding of [(3)H]desipramine to cardiac membranes. The B(max) (fmol/mg protein) in the inferior wall was significantly higher than that in the anterior wall in the control rats (anterior wall, 364 +/- 28; inferior wall, 459 +/- 36: P < 0.05). On the other hand, there was no significant difference in the B(max) value between the anterior and inferior walls in GK rats (anterior wall, 263 +/- 42; inferior wall, 251 +/- 27). In conclusion,...

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Pharmacokinetics and metabolism of 2-[18F]fluoro-2-deoxy-d-glucose (FDG) in mammary tumors of antiestrogen-treated rats

Cited by 11 publications

References 7 publications

2‐[¹⁸F]fluoro‐2‐deoxy‐d‐glucose combined with microdialysis can be used for the comparison of tissue glucose metabolism in obese and lean rats

2‐[¹⁸F]fluoro‐2‐deoxy‐d‐glucose combined with microdialysis can be used for the comparison of tissue glucose metabolism in obese and lean rats

The co-occurrence of zinc deficiency and social isolation has the opposite effects on mood compared with either condition alone due to changes in the central norepinephrine system

Norepinephrine transporter density as a causative factor in alterations in MIBG myocardial uptake in NIDDM model rats

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Pharmacokinetics and metabolism of 2-[18F]fluoro-2-deoxy-d-glucose (FDG) in mammary tumors of antiestrogen-treated rats

Cited by 11 publications

References 7 publications

2‐[18F]fluoro‐2‐deoxy‐d‐glucose combined with microdialysis can be used for the comparison of tissue glucose metabolism in obese and lean rats

2‐[18F]fluoro‐2‐deoxy‐d‐glucose combined with microdialysis can be used for the comparison of tissue glucose metabolism in obese and lean rats

The co-occurrence of zinc deficiency and social isolation has the opposite effects on mood compared with either condition alone due to changes in the central norepinephrine system

Norepinephrine transporter density as a causative factor in alterations in MIBG myocardial uptake in NIDDM model rats

Contact Info

Product

Resources

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2‐[¹⁸F]fluoro‐2‐deoxy‐d‐glucose combined with microdialysis can be used for the comparison of tissue glucose metabolism in obese and lean rats

2‐[¹⁸F]fluoro‐2‐deoxy‐d‐glucose combined with microdialysis can be used for the comparison of tissue glucose metabolism in obese and lean rats