Pharmacokinetics and penetration into tissue fluid of ceftizoxime in normal and hyperthermic sheep

Rule, Roberto; Lacchini, Raúl; Quiroga, Germán; Moreno, Laura; Buschiazzo, Perla de

doi:10.1016/s0921-4488(99)00140-6

Cited by 3 publications

(2 citation statements)

References 18 publications

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“…Several clinical infections are manifested by a rise in body temperature. Pathologic changes induced by E. coli endotoxin have modified the pharmacokinetic behavior of several drugs in different species (Salam Abdullah & Baggot, 1984, 1986; Manna et al ., 1994; Tanira et al ., 1997; Ahmad et al ., 1999; Chaundhary et al ., 1999; Rule et al ., 2000). Alterations in the pharmacokinetics of fluoroquinolones were observed in goats given E. coli endotoxin (Jha et al ., 1996; Rao et al ., 2000), but no such study has been performed with marbofloxacin.…”

Section: Introductionmentioning

confidence: 99%

Influence of Escherichia coli endotoxin‐induced fever on the pharmacokinetic behavior of marbofloxacin after intravenous administration in goats

Waxman

Andrés

González

et al. 2003

Vet Pharm & Therapeutics

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The pharmacokinetic behavior of marbofloxacin was studied in seven healthy goats and in the same goats with induced fever after single-dose intravenous (i.v.) administration of 2 mg/kg b.w. Fever was induced by the administration of Escherichia coli endotoxin. Drug concentration in plasma was determined by high-performance liquid chromatography (HPLC). Drug distribution was somehow altered by fever as febrile goats showed a volume of distribution at steady-state (Vss = 0.72 +/- 0.15 L/kg) lower than normal goats (Vss = 1.19 +/- 0.33 L/kg). The elimination of the drug was also modified. Total plasma clearance (Cl) decreased from 0.24 +/- 0.12 L/kg/h in healthy animals to 0.13 +/- 0.05 L/kg/h in animals with endotoxin-induced fever, which is related to an increase in the area under the plasma concentration-time curve (AUC). Consequently, mean residence time (MRT) was also slightly increased in sick animals (MRT = 5.28 +/- 00.99 and 6.09 +/- 01.45 h, in healthy and febrile animals, respectively).

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Section: Introductionmentioning

confidence: 99%

Influence of Escherichia coli endotoxin‐induced fever on the pharmacokinetic behavior of marbofloxacin after intravenous administration in goats

Waxman

Andrés

González

et al. 2003

Vet Pharm & Therapeutics

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“…Ceftizoxime is a new cephalosporin, which has in‐vitro antibacterial activities similar to those of cefotaxime, moxalactam, and cefoperazone. Ceftizoximeis is characterized by their stability to β‐lactamase inactivation and their market has enhanced in vitro activity against a wide variety of microorganisms, including anaerobic bacteria . Therefore, incorporation of ceftizoxime is important in the suitable matrix in order to study the release kinetics.…”

Section: Introductionmentioning

confidence: 99%

Synthesis of methoxy poly (ethylene glycol)/starch grafted copolymers and investigation of their drug release behavior

Movagharnezhad

Moghadam

2014

Starch Stärke

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Methoxy poly (ethylene glycol)/starch grafted copolymers (MPEG‐g‐S) were synthesized through bromoacetylation of potato starch followed by substitution of methoxy poly (ethylene glycol) (MPEG)with various MWs (MPEG‐500, MPEG‐2000, and MPEG‐5000). Grafting was performed at 50°C. The structure of the copolymers was characterized by FTIR, DSC, Thermal Gravimetric Analysis (TGA), XRD, and AFM. Loading of ceftizoxime antibiotic was carried out on the prepared copolymers and in vitro drug released behavior was investigated in three different media (HCl solution: pH = 3 and buffer solutions: pH = 6 and pH = 8).

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Peripheral distribution of amoxicillin in sheep and influence of local inflammation

Delis

Koutsoviti-Papadopoulou

Theodosiadou

et al. 2010

The Veterinary Journal

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Pharmacokinetics and penetration into tissue fluid of ceftizoxime in normal and hyperthermic sheep

Cited by 3 publications

References 18 publications

Influence of Escherichia coli endotoxin‐induced fever on the pharmacokinetic behavior of marbofloxacin after intravenous administration in goats

Influence of Escherichia coli endotoxin‐induced fever on the pharmacokinetic behavior of marbofloxacin after intravenous administration in goats

Synthesis of methoxy poly (ethylene glycol)/starch grafted copolymers and investigation of their drug release behavior

Peripheral distribution of amoxicillin in sheep and influence of local inflammation

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