1998
DOI: 10.2165/00044011-199816040-00008
|View full text |Cite
|
Sign up to set email alerts
|

Pharmacokinetics and Pharmacodynamics of Newer Oral Cephalosporins

Abstract: Full knowledge of the inter-relationships between pharmacodynamics and pharmacokinetics is important in choosing an appropriate antibiotic, determining its optimal dosage regimen, and predicting which pharmacokinetic parameter(s) should best correlate with clinical efficacy in the treatment of community-acquired lower respiratory tract infections (LRTIs). Pharmacodynamics of antibiotics deal with the time-course of drug activity and mechanisms of action of drugs on bacteria. In particular, the bactericidal act… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1

Citation Types

0
1
0

Year Published

2000
2000
2019
2019

Publication Types

Select...
6

Relationship

0
6

Authors

Journals

citations
Cited by 12 publications
(1 citation statement)
references
References 67 publications
0
1
0
Order By: Relevance
“…11 A study from the USA teaches that cefpodoxime exhibited greater in-vitro activity against S. pneumoniae than cefaclor, cefuroxime axetil, cefprozil, cefixime or loracarbef. 12 Cefpodoxime's excellent PK/PD profile is further substantiated by the fact that it reaches adequate concentrations in the middle-ear fluid of paediatric patients based on recommended dosing frequencies. 11,13 Cefpodoxime is also stable to hydrolysis by commonly encountered plasmid-mediated β-lactamases making it particularly useful in the treatment of upper airways infections where β-lactamases producing organisms are often the source of infection.…”
Section: Introductionmentioning
confidence: 99%
“…11 A study from the USA teaches that cefpodoxime exhibited greater in-vitro activity against S. pneumoniae than cefaclor, cefuroxime axetil, cefprozil, cefixime or loracarbef. 12 Cefpodoxime's excellent PK/PD profile is further substantiated by the fact that it reaches adequate concentrations in the middle-ear fluid of paediatric patients based on recommended dosing frequencies. 11,13 Cefpodoxime is also stable to hydrolysis by commonly encountered plasmid-mediated β-lactamases making it particularly useful in the treatment of upper airways infections where β-lactamases producing organisms are often the source of infection.…”
Section: Introductionmentioning
confidence: 99%