Pharmacokinetics and pharmacodynamics of single and multiple-dose levamisole in belugas (Huso huso): Main focus on immunity responses

Sadati, NadAli Yousefi; Youssefi, Mohammad Reza; Hosseinifard, Seyed Mehdi; Tabari, Mohaddeseh Abouhosseini; Giorgi, Mario

doi:10.1016/j.fsi.2021.04.016

Cited by 9 publications

(6 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The increase in the blood GLU and LACT concentrations demonstrates a response to metabolic stress (Wendelaar Bonga 1997). Our findings agree with those of Pahor-Filho et al (2017), Oliveira et al (2019a), Oliveira et al (2019b), andSadati et al (2021) who also detected an increase in the glucose or lactate concentration in Serrasalmidae (pacu, dog snapper) and beluga (Huso huso) following an LHC treatment. In contrast, an LHC treatment was reported not to affect the glucose concentration in tambaqui (da Silva et al 2021) and juvenile pacu (Sado et al 2010).…”

Section: Discussionsupporting

confidence: 92%

Safety of the anthelminthic drugs levamisole, fenbendazole, and ivermectin administered in therapeutic baths for the common carp Cyprinus carpio

Kolářová¹,

Stará²,

Zusková³

et al. 2022

Vet. Med.

View full text Add to dashboard Cite

Due to the safe "off label" use of selected antiparasitic drugs in fish, we assessed the effects of a therapeutic bath with levamisole (50 mg/l), fenbendazole (25 mg/l), and ivermectin (0.031 mg/l) on the haematological and biochemical blood indices, oxidative and antioxidant variables, and gill histology of the common carp (Cyprinus carpio). Levamisole did not affect the haematological profile, but significantly increased (P < 0.01) the plasma glucose, lactate, and ammonia concentrations, alkaline phosphatase, and alanine aminotransferase activities, TBARS (muscle, liver), total superoxide dismutase activity (muscle), and catalase activity (liver) and significantly decreased (P < 0.01) plasma aspartate aminotransferase and glutathione reductase activity (gill, liver, muscle). Ivermectin led to a significantly (P < 0.01) greater muscle total superoxide dismutase activity compared to the controls, whereas the haematological and biochemical indices remained unchanged. On the other hand, fenbendazole did not affect the haematological or biochemical indices, and the oxidative stress parameters and antioxidant indices did not differ from the controls. The bath in FBZ can be recommended for safe antiparasitic treatment in carp.

show abstract

Section: Discussionsupporting

confidence: 92%

Safety of the anthelminthic drugs levamisole, fenbendazole, and ivermectin administered in therapeutic baths for the common carp Cyprinus carpio

Kolářová¹,

Stará²,

Zusková³

et al. 2022

Vet. Med.

View full text Add to dashboard Cite

show abstract

“…In aquaculture, the dose-dependent effect of levamisole has been suggested, and it seems that the drug mainly affects the innate immune system. Levamisole was well absorbed after oral administration (100 mg/kg) for five consecutive days reducing stress indicators such as cortisol levels and promoting the immune system in belugas [28] . Pahor-Filho et al [29] also reported that 15 days of oral administration of levamisole reduced cortisol levels amid stress responses and promoted immunity against Aeromonas hydrophila infection in fish ( Piaractus mesopotamicus ) [29] .…”

Section: Resultsmentioning

confidence: 99%

The potential immunomodulatory effect of levamisole in humans and farm animals

Gholami,

Rassouli,

Mirzaei

et al. 2024

J Adv Vet Anim Res

View full text Add to dashboard Cite

This study conducted a literature review to investigate the immunomodulatory effect of levamisole in both humans and farm animals. The following procedure was followed for database searching: PubMed, Google Scholar, Web of Science, and Cochrane Library. All research works were updated to September 2022. The terms used in the literature search were included: (“levamisole” OR “immunity” OR “immune system”) AND (“adjuvant” OR “fish” OR “poultry” OR “farm animal” OR “cattle” OR “sheep”). The current review enlightens the extensive potential of levamisole as an adjuvant immunotherapeutic agent and explains its divergent applications beyond its antiparasitic use as an adjuvant, dietary supplement, immunostimulant, antiviral, and anti-cancer drug in humans and farm animals. In the articles examined, various mechanisms have been proposed for levamisole immunoprotective effects, but hormonal alteration and stress hormone reduction are indicated as the main mechanisms in various animal species.

show abstract

“…Plasma LVM and FNB were determined by high‐performance liquid chromatography with UV detection, using established methods (Rummel et al, 2011; Sadati et al, 2021; Tabari et al, 2020). Both methods were revalidated in turtle plasma according to the EMEA bioanalytical method validation guidelines (Anonymous, 2009).…”

Section: Methodsmentioning

confidence: 99%

Pharmacokinetics and therapeutic efficacies of fenbendazole in comparison with levamisole in helminth‐infected Caspian turtles (Mauremys caspica)

Youssefi

Khabbazian

Navidi

et al. 2022

Vet Pharm & Therapeutics

Self Cite

View full text Add to dashboard Cite

The pharmacokinetics and bioavailability of fenbendazole and levamisole were determined in Caspian turtles after a single intravenous (i.v.) and subcutaneous (s.c.) administration. Thirty turtles diagnosed as naturally infected with Serpinema microcephalus and Falcaustra armenica nematodes received fenbendazole (50 mg/kg) or levamisole (10 mg/kg) by i.v. and s.c. administrations. Blood samples were collected at time 0, 0.125, 0.25, 0.5, 1, 2, 4, 8, 12, 24, and 48 h after drug administration. Plasma drug concentrations were determined by a validated high‐performance liquid chromatography method. Data were analyzed by noncompartmental methods. The mean elimination half‐life of levamisole was 5.16 h and 12.03 h for i.v. and s.c. routes, respectively, and for fenbendazole, the mean elimination half‐life was 25.38 h (i.v.) and 29.77 h (s.c.). The total clearance and volume of distribution at steady‐state for levamisole and fenbendazole following i.v. administration were 0.22, 0.44 ml/g/h, and 1.06 and 7.35 ml/g, respectively. For the s.c. route, the peak plasma concentration of levamisole and fenbendazole was 10.53 and 5.24 μg/mL, respectively. The s.c. bioavailability of levamisole and fenbendazole was complete. Considering high anthelmintic efficacy and bioavailability after s.c. administration of levamisole and fenbendazole, and the absence of adverse effects, this route of administration is an easy and efficacious way of treating nematodes in Caspian turtles.

show abstract

Pharmacokinetics and pharmacodynamics of single and multiple-dose levamisole in belugas (Huso huso): Main focus on immunity responses

Cited by 9 publications

References 22 publications

Safety of the anthelminthic drugs levamisole, fenbendazole, and ivermectin administered in therapeutic baths for the common carp Cyprinus carpio

Safety of the anthelminthic drugs levamisole, fenbendazole, and ivermectin administered in therapeutic baths for the common carp Cyprinus carpio

The potential immunomodulatory effect of levamisole in humans and farm animals

Pharmacokinetics and therapeutic efficacies of fenbendazole in comparison with levamisole in helminth‐infected Caspian turtles (Mauremys caspica)

Contact Info

Product

Resources

About