Pharmacokinetics and Tissue Distribution of Enrofloxacin Following Single Oral Administration in Yellow River Carp (Cyprinus carpio haematoperus)

Yang, Fan; Zhang, Chao-Shuo; Duan, Minghui; Wang, Han; Song, Zhe-Wen; Shao, Hao-Tian; Ma, Kaili

doi:10.3389/fvets.2022.822032

Cited by 18 publications

(14 citation statements)

References 47 publications

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“…The terminal half-life (t 1/2λ ) was further estimated as ln (2)/λz (Yang et al, 2022). The area under the concentration versus time curve (AUC) and area under the first moment from 0 to infinity (AUMC 0-∞ ) were calculated using the linear trapezoidal method.…”

Section: Pharmacokinetic Analysismentioning

confidence: 99%

Pharmacokinetics of meloxicam in laying hens after single intravenous, oral, and intramuscular administration

Shao

Yang

Chen

et al. 2022

Vet Pharm & Therapeutics

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The objective of this study was to determine the pharmacokinetics of meloxicam after a single intravenous (IV), intramuscular (IM), and oral (PO) dose at 1 mg/kg body weight in Jing Hong laying hens. Blood samples were collected at predetermined time points. Plasma meloxicam concentrations were determined using a validated high‐performance liquid chromatography (HPLC) assay method and then subjected to a non‐compartmental analysis. After IV administration, meloxicam had a mean (±SD) volume of distribution at steady‐state (Vdss) of 206.50 ± 25.23 ml/kg, a terminal half‐life (t1/2λ) of 5.45 ± 0.53 h, and a total body clearance (Cl) of 26.48 ± 4.13 ml/h/kg. After PO and IM administration, meloxicam was absorbed relatively rapidly: the peak concentrations (Cmaxs) of 3.04 ± 0.56 and 8.94 ± 2.31 μg/ml were observed at 3.08 and 0.80 h, respectively. After PO and IM administration, the absolute bioavailability (F) was determined as 70.13% and 125.50%, respectively. Assuming that hens shared the same analgesic threshold of meloxicam (0.5 μg/ml) with humans, the plasma concentrations after three different routes (PO, IM, and IV) of administration were above this value for 16.7, 19.2, and 14.9 h, respectively.

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Section: Pharmacokinetic Analysismentioning

confidence: 99%

Pharmacokinetics of meloxicam in laying hens after single intravenous, oral, and intramuscular administration

Shao

Yang

Chen

et al. 2022

Vet Pharm & Therapeutics

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“…Especially in China, it has become one of the most commonly farmed fish species. Yellow River carp ( Cyprinus carpio Haematopterus ) is a valuable variety with the crucial economic value among different carp species ( 1 ). It mainly referred to the carp living in the Yellow River.…”

Section: Introductionmentioning

confidence: 99%

Population Pharmacokinetics of Danofloxacin in Yellow River Carp (Cyprinus carpio haematopterus) After One Single Oral Dose

et al. 2022

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This study aimed to determine the population pharmacokinetics of danofloxacin in healthy Yellow River carp (Cyprinus carpio Haematopterus) after single oral administration at 10 mg/kg body weight (BW). A sparse sampling was applied in this study and plasma samples were randomly collected from the tail veins of six carp at 0.25, 0.5, 1, 2, 4, 6, 8, 12, 16, 24, 36, 48, 72, 96, 120 and 144 h after administration. A maximum of four plasma samples was collected from each carp. Then the concentrations of danofloxacin in plasma samples were determined through an HPLC method. Danofloxacin could be quantified in plasma up to 144 h after administration. The corresponding population pharmacokinetic modeling was developed according to the non-linear mixed effect method, including covariate and covariance models to explain some variations from unknown sources and improve the prediction ability. On the premise of sparse sampling, the typical values of the population (fixed effect) and inter-individual variation (random effect) were described by the current population pharmacokinetic model. The estimated typical values and coefficient of variation between individuals (CV%) of absorption rate constant (tvKa), apparent distribution volume (tvV) and clearance (tvCL) were 2.48 h−1 and 0.203%, 47.8 L/kg and 8.40%, 0.694 L/h/kg and 4.35%, respectively. The current danofloxacin oral dosing (10 mg/kg BW) can provide suitable plasma concentrations to inhibit those pathogens with MIC values below 0.016 μg/ml based on the calculated PK/PD indices of AUC/MIC or Cmax/MIC. Further studies are still needed to determine the in vitro and in vivo antibacterial efficacy of danofloxacin against pathogens isolated from Yellow River carp and finally draw a reasonable dosing regimen.

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“…However, Trouchon and Lefebvre reported that both enrofloxacin and ciprofloxacin undergo intestinal recirculation via bile excretion [ 3 ]. In their recent report, Yang et al showed that in Yellow River carp, bile excretion might be the primary elimination route of enrofloxacin [ 33 ].…”

Section: Pharmacokinetics Of Enrofloxacinmentioning

confidence: 99%

Enrofloxacin—The Ruthless Killer of Eukaryotic Cells or the Last Hope in the Fight against Bacterial Infections?

Grabowski

Gaffke

Pierzynowska

et al. 2022

IJMS

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Enrofloxacin is a compound that originates from a group of fluoroquinolones that is widely used in veterinary medicine as an antibacterial agent (this antibiotic is not approved for use as a drug in humans). It reveals strong antibiotic activity against both Gram-positive and Gram-negative bacteria, mainly due to the inhibition of bacterial gyrase and topoisomerase IV enzymatic actions. The high efficacy of this molecule has been demonstrated in the treatment of various animals on farms and other locations. However, the use of enrofloxacin causes severe adverse effects, including skeletal, reproductive, immune, and digestive disorders. In this review article, we present in detail and discuss the advantageous and disadvantageous properties of enrofloxacin, showing the benefits and risks of the use of this compound in veterinary medicine. Animal health and the environmental effects of this stable antibiotic (with half-life as long as 3–9 years in various natural environments) are analyzed, as are the interesting properties of this molecule that are expressed when present in complexes with metals. Recommendations for further research on enrofloxacin are also proposed.

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Pharmacokinetics and Tissue Distribution of Enrofloxacin Following Single Oral Administration in Yellow River Carp (Cyprinus carpio haematoperus)

Cited by 18 publications

References 47 publications

Pharmacokinetics of meloxicam in laying hens after single intravenous, oral, and intramuscular administration

Pharmacokinetics of meloxicam in laying hens after single intravenous, oral, and intramuscular administration

Population Pharmacokinetics of Danofloxacin in Yellow River Carp (Cyprinus carpio haematopterus) After One Single Oral Dose

Enrofloxacin—The Ruthless Killer of Eukaryotic Cells or the Last Hope in the Fight against Bacterial Infections?

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