2021
DOI: 10.1155/2021/8864273
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Pharmacokinetics and Tissue Distribution of Combined Triptolide and Paeoniflorin Regimen for Percutaneous Administration in Rats Assessed by Liquid Chromatography-Tandem Mass Spectrometry

Abstract: Triptolide (TP) has shown potential in rheumatoid arthritis (RA) treatment, but the narrow therapeutic window limits its clinical application. In clinical practice, the compatibility of Tripterygium wilfordii and Paeonia lactiflora is often used to attenuate the toxicity of TP, but its compatibility mechanism has not been fully elucidated. The aim of this study was to investigate the pharmacokinetics and tissue distribution of a combined regimen of TP and paeoniflorin (PF) after transdermal administration in m… Show more

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Cited by 4 publications
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“…By employing a template-assisted layer-by-layer curing method, such MNs with triptolide (TP)/paeoniflorin (Pae) needle tips and BP-hydrogel needle bottoms were generated. TP, as the main component of T. wilfordii , has excellent anti-inflammatory, detoxification, and immunomodulatory effects [ 9 , 42 , 43 ], while Pae is an important extractive of P. lactiflora , which can further enhance the therapeutic effect and decrease the toxicity of TP [ 44 46 ]. When the traditional Chinese medicine integrated responsive MNs were pasted on the skin, their mechanical properties could bring about instant skin penetration to fully contact the lesion regions.…”
Section: Introductionmentioning
confidence: 99%
“…By employing a template-assisted layer-by-layer curing method, such MNs with triptolide (TP)/paeoniflorin (Pae) needle tips and BP-hydrogel needle bottoms were generated. TP, as the main component of T. wilfordii , has excellent anti-inflammatory, detoxification, and immunomodulatory effects [ 9 , 42 , 43 ], while Pae is an important extractive of P. lactiflora , which can further enhance the therapeutic effect and decrease the toxicity of TP [ 44 46 ]. When the traditional Chinese medicine integrated responsive MNs were pasted on the skin, their mechanical properties could bring about instant skin penetration to fully contact the lesion regions.…”
Section: Introductionmentioning
confidence: 99%
“…Triptolide is a diterpene compound isolated from the roots of Tripterygium wilfordii in Celastraceae. Triptolide is a light yellow crystal with stable physical and chemical properties [27,28] . It is insoluble in water, slightly soluble in alcohol and easily soluble in organic solvents.…”
mentioning
confidence: 99%