Pharmacokinetics and tissue distribution of five bioactive components in the <i>Corydalis yanhusuo</i> total alkaloids transdermal patch following Shenque acupoint application in rats assessed by ultra‐performance liquid chromatography–tandem mass spectrometry

Wang, Hui-Nan; Wang, Zhicheng; Jiang, Mingrui; Yue, Zhuzhu; Zhang, Jingqiu; Chen, Mengyu; Wang, Menglin; Wei, Xiaotong; Shi, Shuanghui; Wang, Yingzi

doi:10.1002/bmc.5508

Cited by 2 publications

(1 citation statement)

References 19 publications

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“…9 The topical use of Corydalis yanhusuo in Chinese traditional medicine provides circumstantial evidence for this approach, and several studies have provided transdermal information in this regard. [10][11][12] Liposomes are a sophisticated approach to drug delivery systems. They are primarily composed of lipids and fatty acids that are assembled into bilayer spheres, with the hydrophilic head groups facing the exterior environment and the hydrocarbon chains assembling within the hydrophobic interior of the bilayer.…”

Section: Introductionmentioning

confidence: 99%

Preparation of the Levo-Tetrahydropalmatine Liposome Gel and Its Transdermal Study

Zhang¹,

Li²,

Huang³

et al. 2023

IJN

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The aim of this study was to develop a liposome gel containing levo-tetrahydropalmatine (l-THP) and evaluate its transdermal properties. Methods: A L 16 (4 3 ) orthogonal experiment was conducted to optimize the preparation of l-THP liposomes and assess their characterization and stability in a gel. The transdermal features were analyzed through in vivo and in vitro experiments on rats and Strat-M ® membrane, respectively. The metabolism of l-THP in liver and skin S9 fractions was also studied. Results:The optimization of the orthogonal experiment revealed that the ideal mass ratio of phosphatidylcholine, cholesterol, and l-THP during preparation was 10:1:3. The resulting liposome exhibited a particle size of 68 nm, a PDI of 0.27, a drug loading of 4.33%, an encapsulation of 18.79%, and a zeta potential of −41.27 mV. Both the l-THP and its liposome-gel formulation were found to be stable for a duration of 45 days at 4 °C and 30 °C. During the in vivo transdermal study, the maximum concentration (C max ) of l-THP from the liposome gel was 0.16 μg/mL, and the time to reach this maximum concentration (t max ) was 1.2 hours. The relative bioavailability of l-THP in the liposome gel was 233.8% compared to the emulsion. The concentration of l-THP (prepared in PBS) decreased at a rate of 0.0067 μg/mL/min in the liver S9 fraction and 0.0027 μg/mL/min in the skin S9 fraction, however, this difference was not observed when l-THP was encapsulated in liposomes. l-THP passed through the Strat-M ® membrane at a rate of 0.0032 mg/cm 2 /h and 0.002 mg/cm 2 /h for the emulsion and liposome gel, respectively. Conclusion:The optimal process for the preparation of l-THP liposomes was obtained. Compared to the emulsion, the liposomes provided greater bioavailability when used transdermally. The liposomes also provided greater stability for l-THP during storage.

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Section: Introductionmentioning

confidence: 99%

Preparation of the Levo-Tetrahydropalmatine Liposome Gel and Its Transdermal Study

Zhang¹,

Li²,

Huang³

et al. 2023

IJN

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Composition, Skin Pharmacokinetics, and Pharmacological Effects of the Sanfu Herbal Patch

Li,

Lv,

Liao

et al. 2024

Natural Product Communications

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The Sanfu herbal patch (SHP) is a traditional Chinese medicine external therapy consisting of Sinapis semen, Asari Radix et Rhizoma, Kansui Radix, and Corydalis Rhizoma. The review involved searching for SHP-related keywords in various databases including Web of Science, PubMed, and China National Knowledge Infrastructure, etc Relevant literature was then selected and findings were summarized. The SHP encompasses a diverse array of bioactive constituents, such as fatty acids, thioglycosides, essential oils, terpenes, alkaloids, and additional chemical compounds. The parent constituents of the SHP that enter skin circulation mainly include sinapine thiocyanate from Sinapis semen, asarinin from Asari Radix et Rhizoma, and tetrahydropalmatine from Corydalis Rhizoma. The SHP exhibits anti-inflammatory, antitussive, analgesic, and antitumor properties, making it a valuable pharmacological agent. Moreover, the SHP is frequently employed in clinical settings to address various ailments including asthma, rhinitis, chronic bronchitis, chronic obstructive pulmonary disease, chronic degenerative joint disease, and chronic gastritis. This review focuses on the main components, skin pharmacokinetics, and pharmacological research progress of the SHP, offering valuable insights for further understanding its mechanism of action and enhancing its clinical application.

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Pharmacokinetics and tissue distribution of five bioactive components in the Corydalis yanhusuo total alkaloids transdermal patch following Shenque acupoint application in rats assessed by ultra‐performance liquid chromatography–tandem mass spectrometry

Cited by 2 publications

References 19 publications

Preparation of the Levo-Tetrahydropalmatine Liposome Gel and Its Transdermal Study

Preparation of the Levo-Tetrahydropalmatine Liposome Gel and Its Transdermal Study

Composition, Skin Pharmacokinetics, and Pharmacological Effects of the Sanfu Herbal Patch

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