Pharmacokinetics and tissue distribution of 2,3,5,4′-tetrahydroxystilbene-2-O-β-d-glucoside from traditional Chinese medicine Polygonum multiflorum following oral administration to rats

Lv, Gui‐Yuan; Lou, Zhaohuan; Chen, Suhong; Gu, Hui; Shan, Letian

doi:10.1016/j.jep.2011.05.049

Cited by 68 publications

(58 citation statements)

References 24 publications

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“…The maximum concentration can be reached to tissues at 40 minute post dose. The highest levels of TSG were detected in liver and lung whereas little in brain and testis, indicating TSG could hardly penetrate the blood-brain and blood-testicle barriers [34] .These authors also observed pharmacokinetic profiles of TSG in mice after oral administration of Polygonum Multiflorum extracts. Time to reach maximum concentration in plasma is 60 minute.…”

Section: Tsg Is the Major Bioactive Component Of Polygonum Multiflorummentioning

confidence: 81%

“…TSG is white amorphous powder, soluble in water, ethanol, and methanol. The molecular formula of TSG is C20H22O9; its molecular weight is 406 ( Figure 1) [30][31][32][33][34][35] . According to Chinese Pharmacopoeia 2010 edition, contents of TSG in the raw and processed decoction pieces should be more than 1% and 0.70%, respectively.…”

Section: Tsg Is the Major Bioactive Component Of Polygonum Multiflorummentioning

confidence: 99%

“…HPLC measurement coupled with mass spectrometry, photo-diode array, and chemiluminescence detection have been developed for quantification of TSG [31,[36][37][38][39] . HPLC-UV method was also developed for TSG measurement in rat tissue and plasma after oral administration of Polygonum Multiflorum [33,34] . The aim of drug therapy is to cure, prevent, or control disease status.…”

Section: Tsg Is the Major Bioactive Component Of Polygonum Multiflorummentioning

confidence: 99%

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Potential Application of Tetrahydroxystilbene Glucoside in Treatment of Alzheimer’s Disease

Chen¹,

Chen

Wang

et al. 2016

International Journal of Neurology Research

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Current strategies for Alzheimer's disease (AD) treatment are mainly symptomatic; development of disease-modifying therapies is urgently needed. Polygonum Multiflorum has been used in Traditional Chinese Medicine for long history in treatment of dementia. Pharmacological studies suggested Polygonum Multiflorum could improve learning and memory abilities in animal models of AD, and inhibit β-amyloid (Aβ) production in the brain. 2,3,5,4'-tetrahydroxystilbene-2-O-β-D-glucoside(TSG) is one main bioactive stillbene glycoside of Polygonum Multiflorum. The role of TSG in AD treatment has been investigated recently. TSG might antagonize acetylcholine deficiency and cognitive performance impairment in animal models of AD. In β-amyloid precursor protein (APP) transgenic mice, TSG ameliorated learning and memory functions associated with reductions of senile plaques and Aβ, and inhibitions of γ-secretase and α-synuclein. In Aβ injection rat model, TSG increased cognitive behavior performances, and prevented Aβ deposition and synaptic degeneration. In D-galactose induced aging model, TSG improved abilities of learning and memory, and inhibited expressions of APP and Aβ. Learning and memory deterioration in aged animals was reformed by TSG intervention; its effects may be exerted through APP pathway. TSG also displayed antioxidant activity in vitro and in vivo. In conclusion, TSG has been demonstrated to improve cognitive performances of AD models through multiple target strategies, and may be a future perspective in development of AD therapy.

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Section: Tsg Is the Major Bioactive Component Of Polygonum Multiflorummentioning

confidence: 81%

Section: Tsg Is the Major Bioactive Component Of Polygonum Multiflorummentioning

confidence: 99%

Section: Tsg Is the Major Bioactive Component Of Polygonum Multiflorummentioning

confidence: 99%

See 1 more Smart Citation

Potential Application of Tetrahydroxystilbene Glucoside in Treatment of Alzheimer’s Disease

Chen¹,

Chen

Wang

et al. 2016

International Journal of Neurology Research

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“…Research showed that F. multiflora has potent antioxidative and cytoprotective properties [1], enhanced purgative effects, promoted diuresis and choleretic effects [2], and exerted a neuroprotective effect against glutamate-induced neurotoxicity [3]. 2,3,5,4'-tetrahydroxy stilbene-2-O-ß-Dglucoside (THSG) is an active component in F. multiflora, which possesses anti-hyperlipidemic [4], anti-oxidative, anti-inflammatory, endothelial-protective activities [5]. Furthermore, THSG can protect osteoblastic MC3T3-E1 cells via inhibiting the release of bone-resorbing mediators and oxidative damage of the cells [6], and suppress atherosclerosis by altering the expression of key proteins that may be novel molecular targets responsible for atherogenesis [7].…”

Section: Introductionmentioning

confidence: 99%

“…The pharmacological research revealed that THSG has a potential impact on human health. As a stilbene, THSG and resveratrol (3,5,4'-trihydroxy-trans-stilbene) belong to phenylpropanoids characterized by a 1,2-diphenylethylene backbone. Plant stilbenes are derived from phenylalanine biosynthesis via the general phenylpropanoid pathway.…”

Section: Introductionmentioning

confidence: 99%

Isolation of biosynthesis related transcripts of 2,3,5,4'-tetrahydroxy stilbene-2-O-β-D-glucoside from Fallopia multiflora by suppression subtractive hybridization

et al. 2014

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2,3,5,4'-tetrahydroxy stilbene-2-O-ß-D-glucoside (THSG) exerts multiple pharmacodynamic actions, found in Fallopia multiflora, but the biosynthesis pathway of THSG is still unclear. To clear this ambiguity, we constructed suppression subtractive hybridization (SSH) libraries to screen the genes involved in THSG biosynthesis from two F. multiflora varieties, which vary significantly in THSG content. Twelve non-redundant differentially expressed sequence tags were obtained and the full lengths of 4 unreported fragments were amplified by rapid amplification of cDNA ends. We totally got 7 fulllength transcripts, and all of them were aligned to the transcriptome and digital gene expression tag profiling database of four F. multiflora tissues (root, stem and leaf from Deqing F. multiflora and another root from Chongqing F. multiflora; data unpublished) using local BLAST. The results showed that there was a significant, organ specific difference in the expression of fragments and full-length sequences. All the sequences were annotated by aligning to nucleotide and protein databases. Kyoto Encyclopedia of Genes and Genomes pathway analysis indicated that THSG biosynthesis was correlated with multiple life activities.

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Liquid chromatography/tandem mass spectrometry method for quantification of trans‐stilbene glycoside in rat plasma and its pharmacokinetic application

Wang

Zhu

Peng

et al. 2012

Biomedical Chromatography

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A rapid and sensitive liquid chromatography/tandem mass spectrometry (LC-MS/MS) method was developed and validated for the quantification of trans-stilbene glycoside (SG) in rat plasma. As trans-SG can be rapidly isomerized under light exposure, trans-SG plasma samples were prepared in the dark and assayed immediately. Trans-SG and internal standard were extracted by protein precipitation. Chromatographic separation was achieved on a C(18) column with a gradient elution program. The detection of analytes was performed by negative ion via multiple reaction monitoring mode. The precursor-to-product ions of m/z 405.1 → 242.9 for trans-SG and m/z 389.1 → 226.9 for polydatin (internal standard) were monitored. No interference of endogenous components was observed for any plasma samples that we studied.The method was linear over the concentration range of 1.0-1000.0 ng/mL with a good correlation coefficient. The lower limit of quantification was 1.0 ng/mL for trans-SG. The intra and inter-batch accuracy for trans-SG in stable rat plasma samples ranged from 93.3 to 102.7% and the variation was less than 8.1%. The extraction recoveries of trans-SG in rat plasma were from 102.8 to 112.4% and the matrix effects were also acceptable. This method was successfully applied to pharmacokinetic study of trans-SG in rats after intravenous administration.

show abstract

Pharmacokinetics and tissue distribution of 2,3,5,4′-tetrahydroxystilbene-2-O-β-d-glucoside from traditional Chinese medicine Polygonum multiflorum following oral administration to rats

Cited by 68 publications

References 24 publications

Potential Application of Tetrahydroxystilbene Glucoside in Treatment of Alzheimer’s Disease

Potential Application of Tetrahydroxystilbene Glucoside in Treatment of Alzheimer’s Disease

Isolation of biosynthesis related transcripts of 2,3,5,4'-tetrahydroxy stilbene-2-O-β-D-glucoside from Fallopia multiflora by suppression subtractive hybridization

Liquid chromatography/tandem mass spectrometry method for quantification of trans‐stilbene glycoside in rat plasma and its pharmacokinetic application

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