Pharmacokinetics in rabbits and anti-sphingomyelinase D neutralizing power of Fab, F(ab')2, IgG and IgG(T) fragments from hyper immune equine plasma

Vázquez, Hilda; Olvera, Felipe; Paniagua-Solis, Jorge; Alagón, Alejandro; Sevcik, Carlos

doi:10.1016/j.intimp.2010.01.005

Cited by 26 publications

(10 citation statements)

References 18 publications

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“…We will use the term fabotherapeutic, similar to the Spanish 'faboterapéutico' [1] in reference to the antivenom used, meaning an antitoxin made of F(ab′) or F(ab′) 2 . Fabotherapeutics are used as specific antidotes in envenomations from scorpion stings, the bites of spiders and different species of snakes.…”

Section: Introductionmentioning

confidence: 99%

“…Fabotherapeutics are used as specific antidotes in envenomations from scorpion stings, the bites of spiders and different species of snakes. Fabotherapeutics have a lower mean distribution and elimination times, as well as a larger distribution volume than pure immunoglobulin preparations [2]. With recent F(ab′) 2 purification techniques the risks of allergies, anaphylactic shock and serum sickness are reduced.…”

Section: Introductionmentioning

confidence: 99%

“…Several recent publications suggest that when the intramuscular (im) route is used, antivenoms are poorly effective [3][4][5][6][7][8]. There is information on F(ab′) 2 antiscorpion pharmacokinetics in humans after a bolus of antivenom is given [9], but there is no information on antivenoms used in humans by any other route. We evaluated here the intramuscular F(ab′) 2 's pharmacokinetics in healthy human volunteers.…”

Section: Introductionmentioning

confidence: 99%

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Pharmacokinetics of a F(ab′)2 scorpion antivenom administered intramuscularly in healthy human volunteers

Vázquez¹,

Chávez-Haro²,

García-Ubbelohde³

et al. 2010

International Immunopharmacology

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Pharmacokinetics of a F(ab′)2 scorpion antivenom administered intramuscularly in healthy human volunteers

Vázquez¹,

Chávez-Haro²,

García-Ubbelohde³

et al. 2010

International Immunopharmacology

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“…5a, it was assumed that a subject receiving initially 1 mg of venom received 1 amp antivenom IV 1 h later. The rapid venom neutralization in tissues depends critically on the rapid extravasation of antivenoms observed in rams , humans (Vázquez et al 2005), and rabbits (Quesada et al 2006;Vázquez et al 2010b). 5a indicate that antivenom neutralizes very quickly the venom arriving to the blood plasma and, almost as quickly, the venom already in the tissues.…”

Section: Pharmacokinetics Of Venom Neutralizationmentioning

confidence: 99%

Scorpion Venoms

2015

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In recent years, the field of toxinology has expanded substantially. On the one hand it studies venomous animals, plants and micro organisms in detail to understand their mode of action on targets. While on the other, it explores the biochemical composition, genomics and proteomics of toxins and venoms to understand their three interaction with life forms (especially humans), development of antidotes and exploring their pharmacological potential. Therefore, toxinology has deep linkages with biochemistry, molecular biology, anatomy and pharmacology. In addition, there is a fast-developing applied subfield, clinical toxinology, which deals with understanding and managing medical effects of toxins on human body. Given the huge impact of toxin-based deaths globally, and the potential of venom in generation of drugs for so-far incurable diseases (for example, diabetes, chronic pain), the continued research and growth of the field is imminent. This has led to the growth of research in the area and the consequent scholarly output by way of publications in journals and books. Despite this ever-growing body of literature within biomedical sciences, there is still no all-inclusive reference work available that collects all of the important biochemical, biomedical and clinical insights relating to toxinology. Composed of 11 volumes, Toxinology provides comprehensive and authoritative coverage of the main areas in toxinology, from fundamental concepts to new developments and applications in the field. Each volume comprises a focused and carefully chosen collection of contributions from leading names in the subject.

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“…Surgical intervention should be delayed until the wound stabilizes. Antivenom, with activity against sphingomyelinase D, has been developed, but is not yet available for clinical use (Vazquez et al 2010).…”

Section: Recluse Spidermentioning

confidence: 99%

Basophils

Schroeder

2014

Encyclopedia of Medical Immunology

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Pharmacokinetics in rabbits and anti-sphingomyelinase D neutralizing power of Fab, F(ab')2, IgG and IgG(T) fragments from hyper immune equine plasma

Cited by 26 publications

References 18 publications

Pharmacokinetics of a F(ab′)2 scorpion antivenom administered intramuscularly in healthy human volunteers

Pharmacokinetics of a F(ab′)2 scorpion antivenom administered intramuscularly in healthy human volunteers

Scorpion Venoms

Basophils

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