2019
DOI: 10.14499/indonesianjpharm30iss2pp91-97
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Pharmacokinetics Interaction and Biodistribution of 5 Fluorouracil with Radiopharmaceuticals 99mTc Glutathione for Cancer Diagnostic in Mice Cancer Model

Abstract: Radiopharmaceutical 99m Tc-Glutathione has been developed for cancer diagnostic in nuclear medicine. Interactions between chemotherapy drugs and radiopharmaceuticals can altered radiopharmaceuticals performance. Drug interaction 5-fluorouracil (5-FU) with a radiopharmaceutical 99m Tc-Glutathione in mice cancer model has been proven in pharmacokinetics study. The biological half-life distribution of 99m Tc-Glutathione for cancer model mice when administrated with 5-FU become longer to 0.340±0.121h if compared w… Show more

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Cited by 3 publications
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