Pharmacokinetics of a recombinant bovine growth hormone and pituitary bovine growth hormone in lactating dairy cows

Toutain, P. L.; Schams, D.; Laurentie, Michel; Thomson, T D

doi:10.2527/1993.7151219x

Cited by 5 publications

(2 citation statements)

References 10 publications

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“…Both IRS/PI3K/AKT(PKB)/mTOR pathway and Ras/Raf/(MAPK/ERK) pathway activated by IGF-1 and the JAK/STAT5 pathway activated by rBST/ST-R induce MEC proliferation and survival and increase milk protein synthesis, finally explaining the galactogogue actions of rBST [92] (Figure 4). Its half-life in Holstein cows is 54.8 minutes [93]. Somatotropin is the main galactogogue used in cattle.…”

Section: Synthetic Galactogoguesmentioning

confidence: 99%

Pharmacological Overview of Galactogogues

Penagos-Tabares

Jaramillo

Ruiz-Cortés

2014

Veterinary Medicine International

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Galactogogues are substances used to induce, maintain, and increase milk production, both in human clinical conditions (like noninfectious agalactias and hypogalactias) and in massification of production in the animal dairy industry. This paper aims to report the state of the art on the possible mechanisms of action, effectiveness, and side effects of galactogogues, including potential uses in veterinary and human medicine. The knowledge gaps in veterinary clinical practice use of galactogogues, especially in the standardization of the lactogenic dose in some pure drugs and herbal preparations, are reviewed.

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Section: Synthetic Galactogoguesmentioning

confidence: 99%

Pharmacological Overview of Galactogogues

Penagos-Tabares

Jaramillo

Ruiz-Cortés

2014

Veterinary Medicine International

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“…Figure 1. Somagrebove and somidobove have been rarely used and mainly for research purposes in the 1990s [4,20,21] .…”

Section: Physical-chemical Properties Of Natural and Recombinant Bstmentioning

confidence: 99%

Tracing (r)bST in cattle: Liquid-based options for extraction and separation

Regal

Lamas

Fente

et al. 2017

Journal of Liquid Chromatography & Related Technologies

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Growth hormone (GH) or somatotropin (ST) is a species-specific polypeptide hormone produced in the pituitary gland of vertebrates. When administered exogenously to dairy cattle it has galactopoietic effects and is capable of increasing the milk yield. The beginning of the commercial production of recombinant variants of bovine somatotropin (rbST), by the end of the twentieth century, had a major economic impact in the dairy industry. Recombinant bST enabled large scale applications in farms, enhancing significantly milk production. While it is banned in the European Union (EU), several countries permit the trade and use of recombinant somatotropins in animal husbandry. Also, rbST-free dairy products can be frequently found in the market of those countries, even though these labels are not actually verified in a laboratory. In this context, effective analytical methods are needed for residue control to avoid an illegal use of rbST but also to prevent fraudulent labelling in some cases. The present review includes studies published in the last five years (from 2012 to 2017) to monitor rbST in bovine animals, using liquid-based applications. It is then intended to serve as a practical guide to help 2 those laboratories interested in developing analytical methods to detect rbST use and abuse.

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