Pharmacokinetics of aconitine-type alkaloids after oral administration of Fuzi (Aconiti Lateralis Radix Praeparata) in rats with chronic heart failure by microdialysis and ultra-high performance liquid chromatography–tandem mass spectrometry

Yu, Bing; Cao, Yi; Yao-kang, Xiong

doi:10.1016/j.jep.2015.01.057

Cited by 39 publications

(20 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Aconiti Lateralis Radix Praeparata is known to treat heart failure and has anti-asthmatic and anti-epileptic properties. 19,20 The combination of Aconiti Lateralis Radix Praeparata and Rhei Radix et Rhizoma is also highly compatible, and this combination is often used in various herbal formulae. As these herbs have a certain degree of toxicity, they have to be used in caution and preferably are reserved for extreme cases.…”

Section: Discussionmentioning

confidence: 99%

Herbal medicine and pattern identification for treating COVID-19: a rapid review of guidelines

Ang¹,

Lee²,

Choi³

et al. 2020

Integrative Medicine Research

215

192

View full text Add to dashboard Cite

a b s t r a c tBackground:: Coronavirus disease 2019 is pandemic and has caused illness to many people worldwide. This review aimed to summarize and analyze the herbal formulae provided by the guidelines for their pattern identifications (PIs) and compositions of herbs to treat patients with COVID-19. Methods:: We searched 7 data sources for eligible traditional medicine guidelines up to March 6, 2020 and found a total of 28 traditional medicine guidelines that provide treatment measures for COVID-19. Results:: Of the 28 guidelines, there were 26 government-issued Chinese guidelines and 2 Korean guidelines. After standardizing the terminology of the PIs and herbal formulae, there were 8 PIs and 23 herbal formulae for the mild stage, 11 PIs and 31 herbal formulae for the moderate stage, 8 PIs and 21 herbal formulae for the severe stage, and 6 PIs and 23 herbal formulae for the recovery stage in the Chinese guidelines. In the Korean guidelines, there were 4 PIs and 15 herbal formulae for the mild stage, 3 PIs and 3 herbal formulae for the severe stage, and 2 PIs and 2 herbal formulae for the recovery stage. In the frequency analysis of herbs, Glycyrrhizae Radix et Rhizoma was found to be the herb with the highest frequency of usage in the Chinese guidelines. Conclusion:: This review can be used as guidance for the traditional medicine treatment of COVID-19. Clinical evidence is needed in the future to evaluate the efficacy of traditional medicine.

show abstract

Section: Discussionmentioning

confidence: 99%

Herbal medicine and pattern identification for treating COVID-19: a rapid review of guidelines

Ang¹,

Lee²,

Choi³

et al. 2020

Integrative Medicine Research

215

192

View full text Add to dashboard Cite

show abstract

“…Aconitine-type alkaloids associated with Aconiti Lateralis Radix efficacy have lower intake and slower elimination in CHF rats, indicating a noninterdependent relationship between its efficacy and toxicity [42]. Coupled with P. ginseng , aconitine, mesaconitine, and hypaconitine in Aconiti Lateralis Radix may account for the lower intake and slower elimination in the CHF patient; however, this requires further work to be confirmed.…”

Section: Discussionmentioning

confidence: 99%

Simultaneous Evaluation of the Influence of Panax ginseng on the Pharmacokinetics of Three Diester Alkaloids after Oral Administration of Aconiti Lateralis Radix in Rats Using UHPLC/QQQ‐MS/MS

Yang

Wang

Huang

et al. 2018

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

Objectives To investigate whether Panax ginseng (P. ginseng) could affect the metabolism of Diester Alkaloids (DAs) derived from Aconiti Lateralis Radix in vivo. Methods and Results 24 male Sprague-Dawley rats were randomized for 7-day treatment with P. ginseng (low, middle, and high), or vehicle. Aconiti Lateralis Radix was administered orally to each group on the 8th day. Plasma samples were collected, and Xevo TQ-S was used to detect the concentration of aconitine, mesaconitine, and hypaconitine in plasma. We describe a fast and reproducible method to detect the concentration of aconitine, mesaconitine, and hypaconitine in plasma. Compared to the control group, the AUC(0-t) of three DAs increased in both the middle and high dosing groups. The Vz/F of three DAs in these groups as well as the CLz/F of aconitine in all P. ginseng groups and the CLz/F of mesaconitine and hypaconitine in P. ginseng middle and high groups were decreased compared to the control group. Conclusion Orally administrated P. ginseng potentially inhibits the metabolism of DAs from Aconiti Lateralis Radix in rats.

show abstract

“…ACD ( Fu Zi in Chinese) mainly contains bioactive alkaloids and is frequently administered concomitantly with other herbal medicines in clinical applications. Pharmacological studies have demonstrated that ACD promotes blood circulation to treat CHF, neuralgia, rheumatism, and gout (Xu et al, 2015; Yu, Cao, & Xiong, 2015).…”

Section: Introductionmentioning

confidence: 99%

Quantitative analysis and pharmacokinetic comparison of multiple bioactive components in rat plasma after oral administration of Qi‐Shen‐Ke‐Li formula and its single‐herb extracts using ultra‐high‐performance liquid chromatography–tandem mass spectrometry

Zhou

Zheng

et al. 2020

Biomedical Chromatography

View full text Add to dashboard Cite

Qi‐Shen‐Ke‐Li (QSKL), a traditional Chinese formula prepared from six herbs, has long been used for the treatment of coronary heart disease and chronic heart failure. However, the herbal combination mechanism and underlying material basis of this multi‐herbal formula are not clear. In this study, an ultra‐high‐performance liquid chromatography–tandem mass spectrometry (UHPLC–MS/MS) method to simultaneously determine multiple bioactive compounds in QSKL was established and validated. Using the developed method, 18 bioactive components in rat plasma after oral administration of QSKL formula and its single herb extracts were quantified. Based on these results, pharmacokinetic (PK) parameters (T1/2, Tmax, Cmax, AUC0–48h, and AUC0–∞) of the 18 bioactive components were analyzed and compared using PKSlover 2.0 PK software. The experimental data suggested that significant changes in PK profiles were observed between the QSKL formula and its single‐herb extracts. The herbal combination in QSKL significantly influences the system exposure and the PK behaviors of the 18 bioactive components, indicating multicomponent interactions among the herbs. This study provides insight into the herbal combination mechanism and underlying material basis of the QSKL formula.

show abstract

Pharmacokinetics of aconitine-type alkaloids after oral administration of Fuzi (Aconiti Lateralis Radix Praeparata) in rats with chronic heart failure by microdialysis and ultra-high performance liquid chromatography–tandem mass spectrometry

Cited by 39 publications

References 41 publications

Herbal medicine and pattern identification for treating COVID-19: a rapid review of guidelines

Herbal medicine and pattern identification for treating COVID-19: a rapid review of guidelines

Simultaneous Evaluation of the Influence of Panax ginseng on the Pharmacokinetics of Three Diester Alkaloids after Oral Administration of Aconiti Lateralis Radix in Rats Using UHPLC/QQQ‐MS/MS

Quantitative analysis and pharmacokinetic comparison of multiple bioactive components in rat plasma after oral administration of Qi‐Shen‐Ke‐Li formula and its single‐herb extracts using ultra‐high‐performance liquid chromatography–tandem mass spectrometry

Contact Info

Product

Resources

About