2017
DOI: 10.2460/ajvr.78.12.1372
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Pharmacokinetics of ampicillin-sulbactam in serum and synovial fluid samples following regional intravenous perfusion in the distal portion of a hind limb of adult cattle

Abstract: OBJECTIVE To describe concentration-over-time data for ampicillin and sulbactam in the digital and systemic circulations and synovial fluid (SYN) of cattle following a single injection of ampicillin-sulbactam as a regional IV perfusion (RIVP). ANIMALS 6 healthy adult nonlactating Jersey-crossbred cows. PROCEDURES The right hind limb of each cow was aseptically prepared. A tourniquet was applied around the midmetatarsal region, and 1.0 g of ampicillin with 0.5 g of sulbactam in a combined formulation was admini… Show more

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Cited by 15 publications
(30 citation statements)
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“…The options for local antimicrobial therapy include intravenous and intraosseous regional limb perfusion (10,11) and sustained release of antimicrobials eluted from implanted carriers such as collagen sponges (12), polymethylmethacrylate (13,14), plaster of Paris (PoP) (7)(8)(9), constant rate infusion systems (15), and hydroxyapatite cement (13). Regional perfusions can achieve antimicrobial concentrations many times higher than the MIC of common pathogens, however use is limited to the distal extremity due to the need to place a tourniquet proximal to the area of interest and because high concentrations of drug are generally not maintained for very long after tourniquet removal.…”
Section: Introductionmentioning
confidence: 99%
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“…The options for local antimicrobial therapy include intravenous and intraosseous regional limb perfusion (10,11) and sustained release of antimicrobials eluted from implanted carriers such as collagen sponges (12), polymethylmethacrylate (13,14), plaster of Paris (PoP) (7)(8)(9), constant rate infusion systems (15), and hydroxyapatite cement (13). Regional perfusions can achieve antimicrobial concentrations many times higher than the MIC of common pathogens, however use is limited to the distal extremity due to the need to place a tourniquet proximal to the area of interest and because high concentrations of drug are generally not maintained for very long after tourniquet removal.…”
Section: Introductionmentioning
confidence: 99%
“…Antibiotics reported for use in regional perfusions in cattle include florfenicol, ampicillin-sulbactam, marbofloxacin, and ceftiofur (16)(17)(18)(19). Constant rate infusion systems are also able to achieve high antimicrobial concentrations, however breakage or blockage of the intrasynovial catheter is common (15). Non-biodegradable polymethylmethacrylate implants are easy to use, however removal may be necessary.…”
Section: Introductionmentioning
confidence: 99%
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“…IVRLP with antimicrobials was first reported in cattle in 1974, 5 and several clinical studies investigated its use for the treatment of digital septic lesions. 6 The pharmacokinetics of cefazolin, 7 ceftiofur, 8 florfenicol, 9 tetracycline hydrochloride 3 and ampicillin-sulbactam 10 after IVRLP were defined previously in cattle.…”
Section: Introductionmentioning
confidence: 99%
“…Já uso de antibiótico regional é relatado por 24% dos respondentes. O uso de antibióticos regionais possui a vantagem de apresentar alta concentração local, mas baixa concentração sistêmica e por curto período DEPENBROCK et al, 2017) A imunidade adequada dos animais se mostra um importante fator para a prevenção de doenças. No estudo realizado por , os veterinários acreditavam que a vacinação do rebanho e a transferência de imunidade passiva estão entre as práticas que podem reduzir o uso de antibióticos.…”
Section: Aspectos Do Uso De Aciunclassified