1995
DOI: 10.1016/0010-7824(95)00213-t
|View full text |Cite
|
Sign up to set email alerts
|

Pharmacokinetics of centchroman in healthy female subjects after oral administration

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1
1
1

Citation Types

1
20
0

Year Published

2001
2001
2024
2024

Publication Types

Select...
7
1

Relationship

0
8

Authors

Journals

citations
Cited by 23 publications
(21 citation statements)
references
References 7 publications
1
20
0
Order By: Relevance
“…The maximum serum concentration (C max ) of ORM in humans is dose-dependent (C max of 55.53 ± 15.43 ng/ml for 30 mg dose and C max of 122.57 ± 6.25 ng/ml for 60 mg dose) and is reached within 4–6 hrs(41). Similar C max values for ORM also detected in breast cancer patients treated with either 30 mg, twice a week for 12 weeks (C max 54.98 ± 14.19 ng/ml) or 60 mg of ORM on alternate days for 1 month (C max 135 ± 15.5 ng/ml).…”
Section: Discussionmentioning
confidence: 99%
“…The maximum serum concentration (C max ) of ORM in humans is dose-dependent (C max of 55.53 ± 15.43 ng/ml for 30 mg dose and C max of 122.57 ± 6.25 ng/ml for 60 mg dose) and is reached within 4–6 hrs(41). Similar C max values for ORM also detected in breast cancer patients treated with either 30 mg, twice a week for 12 weeks (C max 54.98 ± 14.19 ng/ml) or 60 mg of ORM on alternate days for 1 month (C max 135 ± 15.5 ng/ml).…”
Section: Discussionmentioning
confidence: 99%
“…Structure-activity relationship analysis revealed regions of ormeloxifene important for ER binding and function (Salman et al, 1983). Pharmacokinetic data have revealed the half-life of a single dose of ormeloxifene (approximately 170 hours) as well as the tissue distribution of ormeloxifene and its metabolite 7-desmethyl ormeloxifene (Paliwal et al, 1989;Lal et al, 1995;Paliwal and Gupta, 1996). Ormeloxifene induces caspase-dependent apoptosis in both ER-positive (MCF-7) and ER-negative (MDA-MB-231) breast cancer cell lines (Nigam et al, 2008).…”
Section: Nuclear Receptors and Their Selective Modulatorsmentioning
confidence: 99%
“…The drug was widely distributed into the tissues, as indicated by the large Vz/f which, on average, was determined to be 111 0-13281 in different studies. The mean total CLif after oral administration was about 611h (PALIWAL et al 1989;LAL et al 1995LAL et al , 1996GUPTA et al 1996). Again, these data should be regarded with caution, because no data on the absolute bioavailability of centchroman are available.…”
Section: Distributionmentioning
confidence: 90%
“…Centchroman was absorbed at a moderate rate and maximum serum concentrations were reached, on average, 4-5 h after oral administration (PALIWAL et al 1989;LAL et al 1995LAL et al , 1996GUPTA et al 1996).…”
Section: Pharmacokinetics In Humans 1 Absorptionmentioning
confidence: 95%