Pharmacokinetics of ciprofloxacin in carp, African catfish and rainbow trout

Nouws, J. F. M.; Grondel, J.L.; Schutte, A. R.; Laurensen, J.

doi:10.1080/01652176.1988.9694173

Cited by 29 publications

(18 citation statements)

References 7 publications

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“…The elimination half-life of ciprofloxacin, being about 2.5 h, is identical for calves, piglets and man (5,16), and is similar to that of flumequine in calves (20). In fish (carp, catfish, trout) the elimination half-life of ciprofloxacin is 5-fold longer (12). Following oral administration of ciprofloxacin to calves, a 3-fold longer plasma drug disposition half-life was noticed than after IV injection (Fig.…”

Section: Pharmacokineticsmentioning

confidence: 86%

Pharmacokinetics, renal clearance and metabolism of ciprofloxacin following intravenous and oral administration to calves and pigs

Nouws¹,

Mevius

Vree

et al. 1988

Veterinary Quarterly

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SUMMARY The pharmacokinetics of ciprofloxacin, a quinoline derivative with marked bactericidal activity against gram-negative bacteria, was studied in calves and pigs following intravenous and oral administration. Ciprofloxacin was rapidly and well distributed in the body, exhibited a short elimination halflife of 2.5 h in both species, and was rapidly absorbed after oral administration (Tnax:2 to 3 h). The oral bioavailability in calves was 53 ± 14% and for 1 pig 37.3%.The renal clearance of the unbound ciprofloxacin for both species was of the same order, indicated a predominantly tubular secretion pattern, and accounted for about 46% of the total drug elimination. No complete drug mass balance could be demonstrated. Small amounts of two metabolites were detected in the urine of calves, but not in pig urine.

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Section: Pharmacokineticsmentioning

confidence: 86%

Pharmacokinetics, renal clearance and metabolism of ciprofloxacin following intravenous and oral administration to calves and pigs

Nouws¹,

Mevius

Vree

et al. 1988

Veterinary Quarterly

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“…Pharmacokinetic information on sarafloxacin is not available for fish species other than Atlantic salmon (Martinsen et al 1993). As the pharmacokinetic properties of drugs may vary significantly between species (Guarino et al 1988, Nouws et al 1988, Grondel et al 1989, the disposition of a drug should be investigated in the particular species in which it is intended to be used.…”

Section: Information Concerning the Pharmacokinetic Properties And CLmentioning

confidence: 99%

Disposition of 14C-sarafloxacin in Atlantic salmon Salmo salar, rainbow trout Oncorhynchus mykiss. cod Gadus morhua and turbot Scophthalmus maximus, as demonstrated by means of whole-body autoradiography and liquid scintillation counting

Martinsen¹,

Horsberg²,

Ingebrigtsen³

et al. 1994

Dis. Aquat. Org.

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The absorption, distribution and elimination of I4C-labelled sarafloxacin hydrochloride were studied by means of whole-body autoradiography and liquid scintillation counting. The drug was administered to Atlantic salmon Salmo salar, rainbow trout Oncorhynchus mykiss, cod Gadus morhua and turbot Scophthalmus maximus, either intravenously or orally in a single dose of 9.6 (3.57) and 9.7 (3.44) mg kg-' (MBq kg-') respectively. The Atlantic salmon, rainbow trout and cod were held in seawater at a temperature of 7.9 f 0.2"C, and the turbot at 12.1 + l . l°C . In the intravenously dosed groups, the drug was rapidly distributed to all major tissues and organs except the central nervous system. After the distribution phase, the levels of radioactivity were higher in most organs and tissues than in blood The most noticeable differences between the species were the lower levels of radioactivity in the Liver, and the higher levels in the muscle tissue, of cod compared to the salmonids. lncomplete absorption was observed following oral administration of sarafloxacin to Atlantic salmon. rainbow trout and turbot. Most of the radioactivity remained in the gastrointestinal tract, high levels of radioactivity othenvise being observed only in the bile and to a certain extent in the liver. The maximum sarafloxacin concentrations (C,,,,,) in blood were calculated to be 0.60, 0.16 and 0.22 pg ml-' for Atlantic salmon, rainbow trout and turbot respectively. In cod a significant degree of absorption took place, with high levels of radioactivity being detected in all major organs and tissues for the first 4 d after administration. The C,,, in blood was calculated to be 2.18 yg ml-l In all 4 species tested, traces of radioactivity remained in the kidney, and also to some extent in the skin, during the excretion phase.

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“…In addition, CIP is reported to be the main metabolite of enrofloxacin, another antibacterial quinolone used in veterinary medicine (22). Although most of the pharmacokinetic work with this drug has been focused on humans (6,9,10,16), some studies have also been carried out on animals, such as rats, monkeys (20,21), rabbits (2,3), pigs, calves (14), horses (28), fish (13), and dogs (1,26). These studies indicate that CIP exhibits favourable pharmacokinetic properties: it is quickly distributed, and its apparent volume of distribution, greater than 1.0 1/kg in all the species studied, suggests substantial tissue penetration.…”

Section: Introductionmentioning

confidence: 99%

Pharmacokinetics of ciprofloxacin in sheep after single intravenous or intramuscular administration

Muñoz

Llovería

Santos

et al. 1996

Veterinary Quarterly

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SUMMARYThe disposition and urinary excretion of ciprofloxacin (CIP) following intravenous (IV) or intramuscular (IM) administration of 7.5 mg/kg body weight in sheep (n = 5) was studied. The intravenous plasma concentration The urinary data showed a significant decrease in the elimination rate constant of CIP when CIP was administered intramuscularly. The other parameters calculated did not display differences between the two routes of administration. The results obtained suggest that when CIP was administered by the IM route in the assayed dose, it was able to maintain serum concentrations above the MIC of most common pathogens over an 8-hour period.

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Pharmacokinetics of ciprofloxacin in carp, African catfish and rainbow trout

Cited by 29 publications

References 7 publications

Pharmacokinetics, renal clearance and metabolism of ciprofloxacin following intravenous and oral administration to calves and pigs

Pharmacokinetics, renal clearance and metabolism of ciprofloxacin following intravenous and oral administration to calves and pigs

Disposition of 14C-sarafloxacin in Atlantic salmon Salmo salar, rainbow trout Oncorhynchus mykiss. cod Gadus morhua and turbot Scophthalmus maximus, as demonstrated by means of whole-body autoradiography and liquid scintillation counting

Pharmacokinetics of ciprofloxacin in sheep after single intravenous or intramuscular administration

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