Pharmacokinetics of dioxidine: Penetration of the drug into organs and tissues after single and repeated introductions

Padeiskaya, E. N.; Shipilova, L. D.; Budanova, L. I.; Sizova, T. N.; Ovdeenko, N. I.; Sedov, V.V.

doi:10.1007/bf01150718

Cited by 4 publications

(1 citation statement)

References 3 publications

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“…The aim of this work is to develop cryochemical modification methods and to produce new cryochemical forms of drug substance dioxidine, 2,3-bis-(hydroxymethyl)-quinoxaline-N,N -dioxide, possessing nanosized particles and modified crystal structure and high dissolution rate in comparison to the initial pharmaceutical substance. Dioxidine is well known antimicrobial substance used for therapy treatment of superlative infections due to inhibition of growth of many of gram-positive and gram-negative bacteria [30,31]. The therapeutic effect of this substance is based on the termination of DNA biosynthesis of microbial cells due to the deep disturbance of its nucleotide structure even by presence of sub-inhibiting concentrations.…”

Section: Introductionmentioning

confidence: 99%

Cryochemically Obtained Nanoforms of Antimicrobial Drug Substance Dioxidine and Their Physico-chemical and Structural Properties

et al. 2018

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Nanoforms of the antimicrobial drug substance 2,3-bis-(hydroxymethyl) quinoxaline-N,N′-dioxide with particles sizes between 50 and 300 nm were obtained by cryochemical modification of the initial pharmaceutical substance using a freeze-drying technique and were characterized by different physicochemical methods (FTIR, UV-Vis, 1H-NMR, DSC, TG and X-ray diffraction) and transmission electron microscopy (TEM). The data obtained from FTIR- and UV–Vis-spectroscopy confirmed the unaltered chemical structure of dioxidine molecules due to the cryochemical modification method. At the same time, X-ray diffraction and thermal analysis data show the change of the crystal structure compared to the parameters of the initial pharmaceutical dioxidine substance. A higher dissolution rate was revealed for cryomodified dioxidine nanoforms. The existence of three polymorphic crystal phases was established for cryomodified dioxidine samples possessed by some thermal activation processes: two anhydrous polymorphic phases, triclinic (T) and monoclinic (M), and one hydrated form (H).

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Section: Introductionmentioning

confidence: 99%

Cryochemically Obtained Nanoforms of Antimicrobial Drug Substance Dioxidine and Their Physico-chemical and Structural Properties

et al. 2018

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Hydroxymethylquinoxalindioxide as levarage points for otorhinolaryngology

Eremeeva,

Nagovskaya,

Morozova

2023

Medicinskij sovet

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Hydroxymethylquinoxaline dioxide, better known as Dioxydin®, holds a special place among topical antimicrobials. The drug has the proven bactericidal action against a wide spectrum of aerobic and anaerobic bacteria, showed good results in otorhinolaryngology as a topical drug to treat bacterial diseases of upper respiratory tract and ear. The authors performed the search for publications among the sources of electronic libraries, such as National Electronic Library (NEB), eLIBRARY, Cyberleninka, Rucont, as well as electronic search engines Pubmed and Google Scholar for the period from 2015 to 2022. The literature analysis resulted in 9 domestic studies, including 6 prospective comparative (4 randomized) studies, two prospective non-comparative studies, and one retrospective descriptive study. The prospective studies involved 400 patients, and the retrospective study analysed the administration in 150 patients. In these studies, hydroxymethylquinoxaline dioxide (Dioxydin®) was used to treat culture-proven infections of upper respiratory tract and ear, both acute and exacerbations of chronic ones. In addition to 0.5% and 1% solutions, which are widely used in ENT practice and need to be prediluted, two new formulations of the drug, fully ready for use, also draws attention: Dioxydin® 2.5 mg/ml, ear drops, and Dioxydin® 0.25 mg/ml, sore throat gargle for topical use. A retrospective review of papers on the use of hydroxymethylquinoxaline dioxide (Dioxydin®) for the topical treatment of upper respiratory tract and ear diseases caused by bacterial agents shows high efficacy, safety and low risk of resistance development. It is promising to conduct studies demonstrating additional therapeutic activity of the Dioxydin®.

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Successful use of hydroxymethylquinoxaline dioxide in complex antimicrobial therapy in patients with fulminant infectious complications in induced hematopoesis aplasia by gram-negative agents

Мезенцева

Ольхова

Мачнева

et al. 2021

Ross. ž. det. gematol. onkol.

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Relevance. Infectious septic complications caused by polyresistant gram-negative micro-organisms are a pressing issue in the treatment of patients after polychemotherapy (PCT) and hematopoietic stem cell transplantation at the high risk of the fulminant current and high lethality against the background of hematopoesis aplasia. One of the therapeutic strategies of antimicrobial treatment is the systematic use of 0.5 % hydroxymethylquinoxaline dioxide (dioxidine) solution in the complex antibacterial therapy of patients with severe infectious-septic complications. The preparation has a bactericidal type of action, a wide spectrum of antibacterial activity. Experience in adult clinical practice has demonstrated the effectiveness of dioxidine in the treatment of the most severe forms of aerobic and anaerobic infection. Strict dose enforcement and injection technique to avoid the appearance of side effects. Data on the intravenous use of dioxin in children are presented in a limited number of scientific literature.The aim of the study was to demonstrate the efficacy of systemic use of hydroxymethylquinoxaline dioxide (0.5 % dioxidine solution) in children with infectious complications progressing against the background of aplasia of hematopoiesis caused by multidrug-resistant pathogens Pseudomonas aeruginosa, Klebsiella pneumoniae, Enterobacter cloacae, Stenotrophomonas maltophilia.Materials and methods. 16 patients with a verified gram-negative infection were prescribed 0.5 % hydroxymethylquinoxaline dioxide solution as part of a combination antimicrobial therapy were included in the retrospective study. The median age of patients was 5 years (6 months – 16 years), 11 (69 %) were boys and 5 (31 %) girls.All children included in the study has infectious-septic complications at the PCT-induced hematopoietic aplasia, obtained according to the protocols of the main disease: severe combined immune deficiency (n = 2), idiopathic aplastic anaemia (n = 3), solid tumor (n = 2), acute myeloblastic leukemia (n = 7), acute lymphoblastic leukemia (n = 2). The main criterion for adding to the study was the existence at the least one site with a verified gram-negative infection (Pseudomonas aeruginosa, Klebsiella pneumoniae, Enterobacter cloacae, Stenotrophomonas maltophilia): bacteriemia (n = 11), oral mucosa (n = 6), ulcerative necrotic damage of perineum (n = 6), enterocolite (n = 6), infectionseptic compartments in the subcutaneous fat (n = 4), pleuropneumonia (n = 4), abscesses and inflammatory infiltration of the liver, spleen, pancreas, kidneys, lymph nodes (n = 1), infection of soft tissues in the area of the ventricular bypass with inflammatory changes of the brain membranes (n = 1).All patients received 0.5 % of the solution of dioxin by injection according of vital importance, as they had pathogens with confirmed laboratory resistance or clinical progression of the infectious process against the background of combined antibacterial therapy.Discussion. There is a complete control of fulminant developing infectious-septic processes caused by polyresistant micro-organisms against the background of hydroxymethylquinoxaline dioxide therapy in all 16 patients. The eradication of the pathogen, according to the microbiological study, has been confirmed in almost all observed patients, the efficacy of the drug has been preserved throughout the period of treatment, and the resistance of micro-organisms has not been observed. Strict adherence to the dosing and infusion technique of hydroxymethylquinoxaline dioxide has helped to achieve the full resolution of the infection process in all children without side-effects.Conclusion. On the basis of the experience presented, in immunocomputed patients of young age, 0.5 % dioxidine solution can be used as a necessary reserve preparation for the treatment of the most severe forms of infections of different localization, caused by polyresistant strains of gram-negative micro-organisms.

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Pharmacokinetics of dioxidine: Penetration of the drug into organs and tissues after single and repeated introductions

Cited by 4 publications

References 3 publications

Cryochemically Obtained Nanoforms of Antimicrobial Drug Substance Dioxidine and Their Physico-chemical and Structural Properties

Cryochemically Obtained Nanoforms of Antimicrobial Drug Substance Dioxidine and Their Physico-chemical and Structural Properties

Hydroxymethylquinoxalindioxide as levarage points for otorhinolaryngology

Successful use of hydroxymethylquinoxaline dioxide in complex antimicrobial therapy in patients with fulminant infectious complications in induced hematopoesis aplasia by gram-negative agents

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