Pharmacokinetics of Doxycycline Reabsorption

Pedersen, Peter Veng; Miller, Raymond

doi:10.1002/jps.2600690224

Cited by 43 publications

(21 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Overall, the pharmacokinetics of doxycycline in patients with CF are consistent with prior studies in non-CF populations (16,17). The C max and T max following a 7-day treatment course of doxycycline at 200 mg orally once daily for Plasmodium falciparum malaria were 4.4 g/ml and 3 h, respectively (16).…”

Section: Discussionsupporting

confidence: 80%

See 1 more Smart Citation

Pharmacokinetics of Doxycycline in Adults with Cystic Fibrosis

Beringer

Owens

Nguyen

et al. 2012

Antimicrob Agents Chemother

View full text Add to dashboard Cite

Section: Discussionsupporting

confidence: 80%

“…This is also suggested by the appearance of multiple peaks observed for several patients. Doxycycline is known to be eliminated through biliary excretion and reabsorbed into the systemic circulation (17).…”

Section: Discussionmentioning

confidence: 99%

Pharmacokinetics of Doxycycline in Adults with Cystic Fibrosis

Beringer

Owens

Nguyen

et al. 2012

Antimicrob Agents Chemother

View full text Add to dashboard Cite

“…The aluminum hydroxide regimen significantly decreased the area under the concentration-time curve by increasing the clearance of doxycycline from 37.4 ± 6.5 to 54.1 ± Because of its enterohepatic recycling, secondary peaks have been reported in the doxycycline serum concentrationtime profiles (4,11). These peakis appeared consistently for our six subjects when they received doxycycline alone, and…”

Section: Resultssupporting

confidence: 50%

“…Doxycycline is eliminated by renal excretion (accounting for 40 to 45% of the dose in 72 h), biliary excretion (accounting for 5% of the dose), and transmucosal secretion into the small intestine. The portion of doxycycline that is secreted into the small intestine is subject to reabsorption if not bound or chelated within the lumen (3,9,11,15).…”

mentioning

confidence: 99%

Effect of oral antacid administration on the pharmacokinetics of intravenous doxycycline

Nguyen

Nix

Gillikin

et al. 1989

Antimicrob Agents Chemother

View full text Add to dashboard Cite

The effect of oral antacid administration on the pharmacokinetics of intravenous doxycycline was studied. In a randomized crossover design, six healthy male volunteers received an infusion of 200 mg of doxycycline hyclate on two occasions separated by 7 days. On one occasion, subjects were given 30 ml of aluminum hydroxide orally four times a day for 4 days, beginning 2 days prior to doxycycline dosing. Blood and urine samples were collected up to 48 and 96 h after the infusion, respectively, and were analyzed by a microbial assay. Values for volume of distribution at steady state, nonrenal clearance, urine recovery, and urine pH were not statistically different among treatment groups. With concomitant antacid therapy, the half-life of intravenous doxycycline was shortened from 16.2 ± 2.6 to 11.2 ± 1.2 h (P = 0.003), and total body clearance increased from 37.4 ± 6.5 to 54.1 ± 12.3 ml/min (P = 0.008). Area under the concentration-time curve for serum was decreased by 18 to 44%, with a 22 to 41% increase in renal clearance. Although the increase in nonrenal clearance ranged from 11 to 128%, the high variability led to a nonsignificant difference (P = 0.07).

show abstract

“…' 22 When compared with other tetracycline derivatives, the absorption of doxycycline from the gastrointestinal tract appears to be less affected by food. Welling et al 3 found that ingestion with test meals reduced the absorption of tetracycline and doxycycline by about 50 and 20 per cent, respectively.…”

Section: Introductionmentioning

confidence: 99%

Absorption of doxycycline from a controlled release pellet formulation: The influence of food on bioavailability

Williams¹,

O'Reilly

Boehm³

et al. 1990

Biopharm & Drug Disp

View full text Add to dashboard Cite

A three-way crossover study was performed to compare the bioavailability of a new pelletised doxycycline product administered either with food or without food and a reference product taken without food. Four different methods were used to calculate pharmacokinetic parameters from the data. The sums of squares, Akaike's Information Criterion (AIC), and the ranges for the parameters obtained were used for comparison. Good fits to the data were obtained when all four methods were used, each with a lag time. The two compartment open model was the most efficient method for describing the data. The one compartment open model was the least efficient, particularly with respect to predicting the peak concentration of doxycycline in plasma. All the models gave similar rank order results with respect to bioavailability differences between the three treatments. Analysis of the data by different methods suggests that pelletised doxycycline is bioequivalent to the reference product when taken in the absence of food. A standardized feeding regimen affected the rate, but not extent of absorption of doxycycline from the pelletised formulation.

show abstract

Pharmacokinetics of Doxycycline Reabsorption

Cited by 43 publications

References 16 publications

Pharmacokinetics of Doxycycline in Adults with Cystic Fibrosis

Pharmacokinetics of Doxycycline in Adults with Cystic Fibrosis

Effect of oral antacid administration on the pharmacokinetics of intravenous doxycycline

Absorption of doxycycline from a controlled release pellet formulation: The influence of food on bioavailability

Contact Info

Product

Resources

About