Pharmacokinetics of Enrofloxacin after Single Intravenous and Oral Bolus Administration in Broiler Chicken

Mekala, P.; Jagadeeswaran, A.; Arivuchelvan, A.; Senthilkumar, P.; Nanjappan, K.; Krishnamurthy, T.

doi:10.23953/cloud.ijavst.192

Cited by 3 publications

(4 citation statements)

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“…C max of enrofloxacin was 3.82 ± 0.59 µg/mL after 0.65 h of PO administration in broiler chicken in this study. The C max obtained by oral administration of enrofloxacin in broiler chicken in another study was 1.63 ± 0.12 µg/mL at 3.58 ± 0.61 h (T max ) [12]. C max values of 1.69 µg/mL at 2.52 h [32]; 1.9 µg/mL at 1.5 h [33]; and 1.5 µg/mL at 9 h [34] were reported after oral administration in chicken in previous studies.…”

Section: Discussionmentioning

confidence: 99%

“…Although the PKs of enrofloxacin have already been studied in many species, including calves, turkeys, horses, goats, sheep, pigs, and chicken [59101112], there is no such report linking the PK and PD of enrofloxacin in broiler chicken within a single investigation. Thus, the current study was designed to describe the PK profiles of enrofloxacin after the administration of 10 mg/kg of body weight (b.w.)…”

Section: Introductionmentioning

confidence: 99%

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Pharmacokinetic and pharmacodynamic integration of enrofloxacin againstSalmonellaEnteritidis after administering to broiler chicken by per-oral and intravenous routes

et al. 2019

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It is crucial to optimize the dose of fluoroquinolones to avoid antibiotic resistance and to attain clinical success. We undertook this study to optimize the dose of enrofloxacin against Salmonella enterica subsp. enterica serovar Enteritidis ( S . Enteritidis) in chicken by assessing its pharmacokinetic/pharmacodynamic (PK/PD) indices. The antibacterial activities of enrofloxacin against S . Enteritidis were evaluated. After administering 10 mg/kg body weight (b.w.) of enrofloxacin to broiler chickens of both sexes by intravenous (IV) and peroral (PO) routes, blood samples were drawn at different intervals and enrofloxacin concentrations in plasma were determined. PK/PD indices were calculated by integrating the PK and PD data. The elimination half-lives (T 1/2 ), time required to reach peak concentration (T max ), peak concentration (C max ), and area under curve (AUC) after administering enrofloxacin by PO and IV routes were 25.84 ± 1.40 h, 0.65 ± 0.12 h, 3.82 ± 0.59 µg/mL, and 20.84 ± 5.0 µg·h/mL, and 12.84 ± 1.4 h, 0.22 ± 0.1 h, 6.74 ± 0.03 µg/mL, and 21.13 ± 0.9 µg.h/mL, respectively. The bioavailability of enrofloxacin was 98.6% ± 8.9% after PO administration. The MICs of enrofloxacin were 0.0625–1 µg/mL against S . Enteritidis strains, and the MIC 50 was 0.50 µg/mL. The C max /MIC 50 were 7.64 ± 0.2 and 13.48 ± 0.7 and the 24 h AUC/MIC 50 were 41.68 ± 0.1 and 42.26 ± 0.3 after administering the drug through PO and IV routes, respectively. The data in this study indicate that the application of 50 mg/kg b.w. of enrofloxacin to chicken through PO and IV routes with a dosing interval of 24 h can effectively cure S . Enteritidis infection, indicating the need for a 5-fold increase in the recommended dosage of enrofloxacin in chicken.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Pharmacokinetic and pharmacodynamic integration of enrofloxacin againstSalmonellaEnteritidis after administering to broiler chicken by per-oral and intravenous routes

et al. 2019

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“…Сьогодні є тенденція до зростання рівня хронічних захворювань птиці бактеріального походження (Lashev et al, 2015). Застосування антибіотиків в птахівництві викликає все більше занепокоєння, адже це несе певні небезпеки (Mekala et al, 2014). Проблема антибіотикорезистентності мікроорганізмів визнана глобальною і в даний час є одним з стратегічних завдань у всьому світі -стримування розвитку і розповсюдження антибіотикорезистентних мікроорганізмів.…”

Section: вступunclassified

“…Препарати, які були ефективними до сьогодні втрачають свої властивості й використання їх вимушено обмежується (Ackermann et al, 2003). Фторхінолони -високоефективні синтетичні антибіотики широкого спектру антимікробної дії, які застосовуються для лікування бактеріальних інфекцій уже 40 років (Papich & Riviere, 2001;Mekala et al, 2014). Це препарати із специфічним механізмом дії на бактеріальні клітини.…”

Section: вступunclassified

Effect of fluoroquinolones on the male chicken reproductive organs

Fotina

Opanasenko

2019

SMLNUVMB

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The using of antibiotics in poultry has some disadvantages. The problem of antibiotic resistance of microorganisms is recognized globally and is currently one of the strategic goals worldwide. Fluoroquinolones are an important and large group of synthetic antimicrobials that have great importance in the treatment of infectious-inflammatory poultry diseases of different etiologies. Fluoroquinolones have high bactericidal activity against a number of bacterial pathogens that infect poultry including E. coli, Hebsiell spp., Pseudomonas spp., Staphylococoeus spp. and Chlamydia spp. Enrofloxacin (ENR) is an antimicrobial agent belonging to the group of third-generation fluoroquinolones. ENR has been historically used as veterinary medicine for treatment of gastrointestinal and respiratory infections in several animal species, including poultrys cursing diseases caused by gram-positive and negative bacteria. Enrofloxacin presents 1,4-dihydro-1-cyclopropyl-7-(4-ethyl-1-piperazinyl)-6-fluoro-4-oxo-3-quinoli;3-quinoline carboxylic acid. A further synthesis allowed the reaching of active substances of cyclopropyl, as an antibacterial action to get further extension. A crystalline active substance with faint yellow color that was obtained to develop in high purity, is hardly soluble in water at pH 7, but as the molecule contains acidic and basic groups, it is easily dissolved at both alkaline and acid pH. The goal of the work. The purpose of our study was to investigate the sperm of male chicken after the use of enrofloxacin and to identify metabolites. Materials and methods of research. The researches were conducted in the conditions of vivarium clinics of the veterinary faculty and laboratories of the department of epizootology and parasitology of Sumy National Agrarian University. 80 male chickens were placed for research, which were kept in metal cages for 5–6 individuals. The use, care and transportation of birds for toxicological research were with all applicable animal welfare laws. All reasonable steps were taken to avoid or minimize discomfort, distress or pain of birds. Results of research and discussion. The differences between normal motility and defect sperm in control and enrofloxacin treated birds were not founded. Weight of testes, wattles and combs was not affected by drug. Ascorbic acid, total protein, testosterone and cholesterol concentration were similar in control and enrofloxacin treated groups. It is suggested that enrofloxacin at doses used were safe for male chicken. The administration of the drug “Enzin 10%” to the male chicken did not affect the concentration of ascorbic acid in the testicles, total protein and cholesterol. These indicators are actively involved in spermatogenesis. Thus, it can be concluded that the use of the drug “Enzin 10%” at therapeutic doses for 10 days had no negative effect on spermatogenesis of the male chicken.

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Toxicity induced by ciprofloxacin and enrofloxacin: oxidative stress and metabolism

Badawy

Yang

Liu

et al. 2021

Critical Reviews in Toxicology

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Pharmacokinetics of Enrofloxacin after Single Intravenous and Oral Bolus Administration in Broiler Chicken

Cited by 3 publications

References 11 publications

Pharmacokinetic and pharmacodynamic integration of enrofloxacin againstSalmonellaEnteritidis after administering to broiler chicken by per-oral and intravenous routes

Pharmacokinetic and pharmacodynamic integration of enrofloxacin againstSalmonellaEnteritidis after administering to broiler chicken by per-oral and intravenous routes

Effect of fluoroquinolones on the male chicken reproductive organs

Toxicity induced by ciprofloxacin and enrofloxacin: oxidative stress and metabolism

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