Pharmacokinetics of florfenicol and its metabolite, florfenicol amine, in the Korean catfish (Silurus asotus)

Abstract

The pharmacokinetics of florfenicol and its metabolite, florfenicol amine, was investigated after its intravenous (i.v.) and oral (p.o.) administration of 20 mg/kg of body weight in Korean catfish (Silurus asotus). After i.v. florfenicol injection (as a bolus), the terminal half-life (t(1/2)), the volume of distribution at steady state (V(dss)), and total body clearance were 11.12 +/- 1.06 h, 1.09 +/- 0.09 L/kg and 0.07 +/- 0.01 L x kg/h respectively. After p.o. administration of florfenicol, the t(1/2), C(max), t(max) and oral bioavailability (F) were 15.69 +/- 2.59 h, 9.59 +/- 0.36 microg/mL, 8 h and 92.61 +/- 10.1% respectively. Florfenicol amine, an active metabolite of florfenicol, was detected in all fish. After i.v. and p.o. administration of florfenicol, the observed C(max) values of florfenicol amine (3.91 +/- 0.69 and 3.57 +/- 0.65 mg/L) were reached at 0.5 and 7.33 +/- 1.15 h. The mean metabolic rate of florfenicol amine after i.v. and p.o. administration was 0.4 and 0.5 respectively.

Pharmacokinetics of florfenicol and its major metabolite, florfenicol amine, in rabbits

“…and p.o administrations respectively. These values were prominently higher than those of our previous report in Korean catfish ( Silurus asotus ; Park et al. , 2006).…”

Pharmacokinetic Study of Florfenicol in Healthy and Vibriosis-infectedPseudosciaena croceaafter Oral Administration

“…The proportionality constant relating drug concentration in the serum to the amount of drug in the body has been termed the apparent volume of distribution (V d ). The V d of florfenicol in serum of Korean catfish (Park, 2006) and Atlantic salmon (Martinsen and Horsberg, 1995) was 1.09 and 1.12 L kg −1 , respectively. In the present study, the V d of florfenicol in healthy and infected P. crocea serum was 2.87 and 3.45 L kg −1 , respectively, most likely owing to the difference in the route of administration and species.…”

“…There are some reports of its pharmacokinetics determined in Oncorhynchus mykiss, Piaractus brachypomus, P. crocea, Gadus morhua, Salmo salar, Acipenser baeri, Anguilla anguilla, Tilapia, Silurus asotus, and Crucian carp (Horsberg et al, 1996;Lunden and Bylund, 2000;Samuelsen et al, 2003;Lewbart et al, 2005;Park et al, 2006;Feng and Jia, 2008;Bowser, 2009;Sun et al, 2010;Qin et al, 2010;Xie et al, 2012).…”

Tilmicosin‐ and florfenicol‐loaded hydrogenated castor oil‐solid lipid nanoparticles to pigs: Combined antibacterial activities and pharmacokinetics

“…FF showed strong in vitro antimicrobial activities (MIC 90 ≤ 1 μg/ml) against APP , Pasteurella multocida , Mannheimia haemolytica, and Bordetella bronchiseptica isolates with MICs ranging from 0.12 to 4 μg/ml (Shin, Kang, Nabin, Kang, & Yoo, ). The PKs of FF have been reported in various animals, including camel (Al‐Nazawi & Homeida, ), cattle (Lobell et al., ), dog (Park et al., ), goat (Verma, Ahmad, Rahal, & Singh, ), pig (Jiang, Zeng, Chen, Liu, & Fung, ; Li et al., ), rabbit (Abd ElAty et al., ), sheep (Lane et al., ), and aquatic species (Park, Lim, Kim, & Yun, ).…”