Pharmacokinetics of florfenicol following intramuscular and intravenous administration in olive flounder (<i>Paralichthys olivaceus</i>)

Lim, Jong-Hwan; Kim, M.-S.; Hwang, Youn–Hwan; Song, In-Bae; Park, B.-K.; Yun, Hyo-In

doi:10.1111/j.1365-2885.2010.01231.x

Cited by 18 publications

(14 citation statements)

References 19 publications

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“…However, the value of Cl for other flatfish as olive flounder (Lim et al . ) was more in agreement with the values obtained for turbot with a Cl of 0.017 L kg h −1 ). This is illustrated by the fact that the AUC corresponding to turbot (365.95 h μg mL −1 ) was larger than those obtained for Atlantic salmon by Horsberg et al .…”

Section: Resultssupporting

confidence: 91%

“…However, this value was very similar to the value obtained for other flat fish such as olive flounder (Lim et al . ). Although this work dealt with different species, flatfish share similar physiological characteristics and play an important role in drug absorption, elimination and metabolism in fish.…”

Section: Resultsmentioning

confidence: 97%

“…(), Martinsen et al . (), as 133 and 116.3 h μg mL −1 , respectively, and inversely, to the AUC obtained for Lim et al ., (617.60 h μg mL −1) . Pinault et al .…”

Section: Resultsmentioning

confidence: 99%

“…), olive flounder (Lim et al . ), crucian carp (Zhao et al . ), and more recently, in other species as orange‐spotted grouper (Feng et al .…”

Section: Introductionmentioning

confidence: 99%

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Pharmacokinetic model of florfenicol in turbot (Scophthalmus maximus): establishment of optimal dosage and administration in medicated feed

Ocenda

Almeida-Prieto

Luzardo-Álvarez

et al. 2016

Journal of Fish Diseases

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The pharmacokinetics of florfenicol (FF) in turbot (Scophthalmus maximus) was studied after single intravenous (10 mg kg ) and oral (100 mg kg ) administration. The plasma concentration-time data of florfenicol were described by an open one-compartment model. The elimination half-life (t ) was estimated to be 21.0 h, and the total body clearance, Cl, was determined as 0.028 L kg h . The apparent volume distribution (V ) was calculated to be 0.86 L kg and the mean residence time (MRT ) was 30.2 h. Following oral administration, the maximum plasma concentration (C ) of 55.4 μg mL was reached at 12 h (T ). The absorption constant (k ) was 0.158 h . The bioavailability was estimated to be 57.1%. The low bioavailability observed at higher doses was explained by the saturation of the mechanisms of absorption. The drug absorption process was limited by its inherent low solubility, which limited the amount of available FF absorbed in the gastrointestinal tract. Based on the pharmacokinetic data, an optimal dosing schedule for FF administration is hereby provided. Based on the minimum inhibitory concentration found for susceptible strains of Aeromonas salmonicida, oral FF administration of first, an initial dose of 30 mg FF kg , followed by 6 maintenance doses at 18 mg kg /daily could be effective against furunculosis in turbot.

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Section: Resultssupporting

confidence: 91%

Section: Resultsmentioning

confidence: 97%

“…(), Martinsen et al . (), as 133 and 116.3 h μg mL −1 , respectively, and inversely, to the AUC obtained for Lim et al ., (617.60 h μg mL −1) . Pinault et al .…”

Section: Resultsmentioning

confidence: 99%

“…), olive flounder (Lim et al . ), crucian carp (Zhao et al . ), and more recently, in other species as orange‐spotted grouper (Feng et al .…”

Section: Introductionmentioning

confidence: 99%

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Pharmacokinetic model of florfenicol in turbot (Scophthalmus maximus): establishment of optimal dosage and administration in medicated feed

Ocenda

Almeida-Prieto

Luzardo-Álvarez

et al. 2016

Journal of Fish Diseases

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“…Florfenicol (FLR) is the most commonly used antibacterial drug in world aquaculture, which is a synthetic drug with chemical structure and spectrum of bactericidal activity similar to chloramphenicol, and has been shown to have potent activity against several pathogenic bacteria (Caipang, Lazado, Brinchmann, Berg & Kiron ; Fodey, George, Traynor, Delahaut, Kennedy, Elliott & Crooks ). Previous FLR pharmacokinetic studies in aquaculture were performed mainly on finfishes (Malvisi, Della Rocca, Anfossi, Tomasi, Di Salvo, Zanchetta, Magni, Sello & Giorgetti ; Lewbart, Papich & Whitt‐Smith ; Park, Lim, Kim & Yun ; Sun, Zhao, Shan, Zhu, Zeng & Liu ; Lim, Kim, Hwang, Song, Park & Yun ; Zaki et al . ; Zhao, Zhang, Bai, Zhu, Shan, Zeng & Sun ).…”

Section: Introductionmentioning

confidence: 99%

Tissue distribution, elimination of florfenicol and its effect on metabolic enzymes and related genes expression in the white shrimpLitopenaeus vannameifollowing oral administration

2014

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Florfenicol (FLR) is a commonly used antibiotic for the treatment of bacterial diseases in white shrimpLitopenaeus vannamei. In this study, we evaluated the tissue distribution and elimination, changes of selected metabolism enzymes and transcriptional activity of metabolism-related genes following oral administration of FLR. Shrimp (9.5 AE 0.5 cm) were fed coated with FLR 100 mg kg À1 and 200 mg kg À1 body weight for 6 days followed by a period of feeding without antibiotic for 10 days to evaluate the elimination pattern. Gill, hepatopancreas and muscle tissues were collected on the 3rd, 6th day of feeding the antibiotics and at 3, 5 and 10 days after FLR withdrawal. The concentration of FLR residue in hepatopancreas was significantly higher than that in other tissues. Ethoxyresorufin-O-deethylase (EROD) and glutathione-S-transferase (GST) activities were significantly increased in gill and hepatopancreas of FLR-fed shrimp until the 6th day post withdrawal. Furthermore, transcriptional profiles of selected genes (CYP1A1, CYP3, CYP4, GST) were dependent on the dosage of antibiotics that was administered and the time of sampling. Results in this study were expected to provide additional contribution to the emerging field of crustaceans in understanding the pharmacokinetic and the metabolic progress of L. vannamei following oral administration.

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Medical Treatment

Vergneau‐Grosset¹,

Lair²

2021

Clinical Guide to Fish Medicine

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Pharmacokinetics of florfenicol following intramuscular and intravenous administration in olive flounder (Paralichthys olivaceus)

Cited by 18 publications

References 19 publications

Pharmacokinetic model of florfenicol in turbot (Scophthalmus maximus): establishment of optimal dosage and administration in medicated feed

Pharmacokinetic model of florfenicol in turbot (Scophthalmus maximus): establishment of optimal dosage and administration in medicated feed

Tissue distribution, elimination of florfenicol and its effect on metabolic enzymes and related genes expression in the white shrimpLitopenaeus vannameifollowing oral administration

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