Pharmacokinetics of Higenamine in Rabbits

Lo, Chi-Fang; Chen, Chi-Ming

doi:10.1002/(sici)1099-081x(199612)17:9<791::aid-bdd993>3.0.co;2-t

Cited by 18 publications

(21 citation statements)

References 3 publications

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“…Protein binding to caffeine in humans has been measured to be 15-35% (Axelrod and Reichenthal, 1953;Blanchard, 1982;Desmond et al, 1980). Higenamine is 54.8% bound to plasma proteins in the rabbit (Lo and Chen, 1996). No human data on the degree of plasma protein binding for higenamine have been published.…”

Section: Tablementioning

confidence: 69%

A beating heart cell model to predict cardiotoxicity: Effects of the dietary supplement ingredients higenamine, phenylethylamine, ephedrine and caffeine

Calvert

Vohra

Ferguson

et al. 2015

Food and Chemical Toxicology

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Section: Tablementioning

confidence: 69%

A beating heart cell model to predict cardiotoxicity: Effects of the dietary supplement ingredients higenamine, phenylethylamine, ephedrine and caffeine

Calvert

Vohra

Ferguson

et al. 2015

Food and Chemical Toxicology

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“…These values were obtained using noncompartmental analysis. In general, after the dose uniformizing, there were significant differences between the major pharmacokinetic parameters in Chinese subjects and those in rabbits [13].…”

Section: Application Of the Methods In Pharmacokinetic Studiesmentioning

confidence: 99%

Determination of higenamine in human plasma and urine using liquid chromatography coupled to positive electrospray ionization tandem mass spectrometry

Feng

Jiang

2011

Journal of Chromatography B

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“…at a dose of 30.0, 15.0, or 3.0 mg/kg. Blood (300 μL) was collected in EDTA-coated tubes at 0,5,10,15,20, 25, 30, 40, 50, 60, 75, 90, 120, and 150 min after administration of the dose with six animals used for each time point.…”

mentioning

confidence: 99%

A pharmacokinetics study of orally administered higenamine in rats using LC–MS/MS for doping control analysis

Wang

Xiong

Yang

et al. 2020

Drug Testing and Analysis

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According to WADA guidelines, the presence of Higenamine (HG) in urine should not be ≥10 ng/mL. HG is widely found in materials used in Chinese herbal medicines as well as food and additives. This paper is the first method wherein a rat model has been used to evaluate the pharmacokinetics of orally administered HG by LC–MS/MS and would be helpful in doping control analysis. The method was found to be linear over a concentration range of 0.5(lower limit of quantification, LLOQ)–500 ng/mL for plasma and 0.5(LLOQ)–1000 ng/mL for urine. The values for intra‐ and inter‐day accuracy and precision did not deviate by >12.25% for HG in plasma and 5.87% in urine. Extraction recoveries of HG were 70.30–86.71% from plasma and 74.93%–79.29% from urine. HG was stable in plasma and urine after the extraction process and when exposed to different storage conditions. The findings of this study could provide some reference value for the assessment of HG misuse and for the control of intake and external application of HG‐related materials (foods and medicinal herbs). Our key findings are that high levels of external application or oral administration of HG‐rich materials may lead to a positive urine test for HG in athletes.

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Pharmacokinetics of Higenamine in Rabbits

Cited by 18 publications

References 3 publications

A beating heart cell model to predict cardiotoxicity: Effects of the dietary supplement ingredients higenamine, phenylethylamine, ephedrine and caffeine

A beating heart cell model to predict cardiotoxicity: Effects of the dietary supplement ingredients higenamine, phenylethylamine, ephedrine and caffeine

Determination of higenamine in human plasma and urine using liquid chromatography coupled to positive electrospray ionization tandem mass spectrometry

A pharmacokinetics study of orally administered higenamine in rats using LC–MS/MS for doping control analysis

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