Pharmacokinetics of lidocaine after intravenous administration to cows

Cox, Sherry; Wilson, Jeanne M.; Doherty, Thomas J

doi:10.1111/j.1365-2885.2011.01328.x

Cited by 10 publications

(1 citation statement)

References 37 publications

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“…Lidocaine is used in a variety of local anesthetic procedures, both in human and veterinary medicine, and its pharmacokinetics has been studied in different species for over 40 years [8,9]. Its destiny after intravenous and extravascular administration has been studied with different formulations, dosages or anesthetic contexts [10–12].…”

Section: Introductionmentioning

confidence: 99%

Pharmacokinetics of Lidocaine Hydrochloride Administered with or without Adrenaline for the Paravertebral Brachial Plexus Block in Dogs

et al. 2017

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Adrenaline is known to prolong the duration of local anesthesia but its effects on the pharmacokinetic processes of local anesthetic drugs are not fully understood. Our objective was to develop a compartmental model for quantification of adrenaline’s impact on the pharmacokinetics of perineurally-injected lidocaine in the dog. Dogs were subjected to paravertebral brachial plexus block using lidocaine alone or adrenalinated lidocaine. Data was collected through a prospective, randomised, blinded crossover protocol performed over three periods. Blood samples were collected during 180 minutes following block execution. Compartmental pharmacokinetic models were developed and their goodness-of-fit were compared. The lowering effects of adrenaline on the absorption of lidocaine were statistically determined with one-sided tests. A one-compartment disposition model with two successive zero-order absorption processes best fitted our experimental data. Adrenaline decreased the peak plasma lidocaine concentration by approximately 60% (P < 0.001), decreased this local anesthetic’s fast and slow zero-order absorption rates respectively by 50% and 90% (P = 0.046, and P < 0.001), which respective durations were prolonged by 90% and 1300% (P < 0.020 and P < 0.001). Lidocaine demonstrated a previously unreported atypical absorption profile following its paravertebral injection in dogs. Adrenaline decreased the absorption rate of lidocaine and prolonged the duration of its absorption.

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