1998
DOI: 10.1002/(sici)1099-081x(1998110)19:8<501::aid-bdd127>3.0.co;2-g
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Pharmacokinetics of minoxidil in patients with cirrhosis and healthy volunteers

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Cited by 12 publications
(8 citation statements)
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“…For the serum minoxidil-O-glucuronide, the average halflife for healthy volunteers is 1.7 h, 5 thus the serum half-life of minoxidil-O-glucuronide is similar to that of minoxidil. In terms of urinary excretion, approximately 20% and 40% of an oral dose are excreted in the urine as unchanged minoxidil and minoxidil-O-glucuronide, respectively.…”
Section: Discussionmentioning
confidence: 93%
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“…For the serum minoxidil-O-glucuronide, the average halflife for healthy volunteers is 1.7 h, 5 thus the serum half-life of minoxidil-O-glucuronide is similar to that of minoxidil. In terms of urinary excretion, approximately 20% and 40% of an oral dose are excreted in the urine as unchanged minoxidil and minoxidil-O-glucuronide, respectively.…”
Section: Discussionmentioning
confidence: 93%
“…Minoxidil has a large volume of distribution (mean of 197 L in healthy subjects). 5 RiUP X5 â contains 5 g minoxidil per 100 mL of solution. In our case, the patient ingested 60 mL of the solution, equaling 3,000 mg minoxidil, which is approximately 80-300 times greater than the recommended therapeutic oral dose for controlling hypertension (10-40 mg daily dose for adults).…”
Section: Discussionmentioning
confidence: 95%
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“…Shows the mean plasma concentration-time curve of minoxidil: plasma concentration reached a maximum 1.50 ± 0.20 h after dosing with a level of 56.85 ± 8.20 ng ml −1 . These results are agreement with previous reports [2,10].…”
Section: Resultsmentioning
confidence: 99%