Pharmacokinetics of oxytetracycline in clinical cases in the red-necked wallaby (Macropus rufogriseus)

Kirkwood, James; Gulland, F.M.D.; Needham, J. R.; Vogler, M.G.

doi:10.1016/s0034-5288(18)30867-1

Cited by 8 publications

(14 citation statements)

References 8 publications

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“…The elimination T ½ of oxytetracycline reported here is much shorter than that reported in 10.4 ± 1.4 kg red‐necked wallabies (11.45 h; Kirkwood et al. , 1988).…”

Section: Discussioncontrasting

confidence: 61%

“…The V z in tammar wallabies does not appear to be different from that reported in red‐necked wallabies (2.041 L/kg; Kirkwood et al. , 1988).…”

Section: Discussionmentioning

confidence: 51%

“…, 2009). The elimination T ½ of oxytetracycline in three red‐necked wallabies ( Macropus rufogriseus ) (Kirkwood et al. , 1988) was found to be far slower than that predicted by an allometric equation for this parameter established for eutherians (Kirkwood & Widdowson, 1990).…”

Section: Introductionmentioning

confidence: 88%

“…Very little pharmacologic research on marsupials has been published (Clark et al. , 1982; Kirkwood et al. , 1988; McLelland et al.…”

Section: Introductionmentioning

confidence: 99%

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Single‐dose pharmacokinetics of oxytetracycline and penicillin G in tammar wallabies (Macropus eugenii)

McLelland¹,

Barker²,

Crawshaw³

et al. 2011

Vet Pharm & Therapeutics

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The pharmacokinetics of oxytetracycline and penicillin G was investigated in tammar wallabies (Macropus eugenii). Groups of eight healthy tammar wallabies were administered i.v. oxytetracycline hydrochloride (40 mg/kg), i.m. long-acting-oxytetracycline (20 mg/kg), i.v. sodium penicillin G (30 mg/kg), or i.m. procaine/benzathine penicillin G (30 mg/kg). Plasma concentrations of oxytetracycline were determined using high-performance liquid chromatography. Pharmacokinetic parameters were comparable to those reported for eutherians of equivalent size and suggest that the practice of adjusting allometrically scaled doses to account for the lower metabolic rate of marsupials may not be valid. Long-acting oxytetracycline and penicillin G both demonstrated depot effects. However, the plasma concentrations achieved question the therapeutic efficacy of the long-acting preparations.

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“…The elimination T ½ of oxytetracycline reported here is much shorter than that reported in 10.4 ± 1.4 kg red‐necked wallabies (11.45 h; Kirkwood et al. , 1988).…”

Section: Discussioncontrasting

confidence: 61%

“…The V z in tammar wallabies does not appear to be different from that reported in red‐necked wallabies (2.041 L/kg; Kirkwood et al. , 1988).…”

Section: Discussionmentioning

confidence: 51%

Section: Introductionmentioning

confidence: 88%

“…Very little pharmacologic research on marsupials has been published (Clark et al. , 1982; Kirkwood et al. , 1988; McLelland et al.…”

Section: Introductionmentioning

confidence: 99%

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Single‐dose pharmacokinetics of oxytetracycline and penicillin G in tammar wallabies (Macropus eugenii)

McLelland¹,

Barker²,

Crawshaw³

et al. 2011

Vet Pharm & Therapeutics

View full text Add to dashboard Cite

show abstract

“…However, there is currently only one published pharmacokinetic study in a marsupial, describing the kinetics of intravenous oxytetracycline in three rednecked wallabies (Macropus rufogriseus). 6 It has been proposed that the 30% lower metabolic rate of marsupials 3 be accounted for when extrapolating drug dosages from eutherian species. 12 This requires that marsupials be administered a given drug at a lower dosage and less frequently than eutherians.…”

Section: Introductionmentioning

confidence: 99%

The Pharmacokinetics of Single Dose Intramuscular Amoxicillin Trihydrate in Tammar Wallabies (Macropus eugenii)

McLelland¹,

Rich²,

Holz³

2009

Journal of Zoo and Wildlife Medicine

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Five tammar wallabies (Macropus eugenii) were injected intramuscularly with 10 mg/kg amoxicillin trihydrate. Serial blood samples were collected through to 26 hr postinjection. Plasma amoxicillin concentrations were measured using high-performance liquid chromatography. Pharmacokinetic parameters were estimated using noncompartmental analysis. The terminal half-life (1.77 +/- 0.40 hr) was comparable to that previously reported in domestic small ruminants. Without intravenous kinetic data, it is unclear whether the terminal phase is elimination- or absorption-dependent; both scenarios have been reported in domestic species. Plasma concentrations of amoxicillin remained above a reported minimum inhibitory concentration (MIC) breakpoint for staphylococci and streptococci for at least 8 hr; the MIC breakpoint for enterobacteria and enterococci was never attained.

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Marsupials

2019

Zoo and Wild Mammal Formulary

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Pharmacokinetics of oxytetracycline in clinical cases in the red-necked wallaby (Macropus rufogriseus)

Cited by 8 publications

References 8 publications

Single‐dose pharmacokinetics of oxytetracycline and penicillin G in tammar wallabies (Macropus eugenii)

Single‐dose pharmacokinetics of oxytetracycline and penicillin G in tammar wallabies (Macropus eugenii)

The Pharmacokinetics of Single Dose Intramuscular Amoxicillin Trihydrate in Tammar Wallabies (Macropus eugenii)

Marsupials

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